Improvement in mood and ideation associated with increase in right caudate volume
Abstract Background The basal ganglia, particularly caudate, are hypothesized to play a role in affective and obsessive-compulsive disorders. The depressive syndrome is a feature of untreated Cushing's disease. The objective of this study was to test the hypothesis that after treatment of Cushi...
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| Veröffentlicht in: | Journal of affective disorders 2007-08, Vol.101 (1), p.139-147 |
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| creator | Starkman, Monica N Giordani, Bruno Gebarski, Stephen S Schteingart, David E |
| description | Abstract Background The basal ganglia, particularly caudate, are hypothesized to play a role in affective and obsessive-compulsive disorders. The depressive syndrome is a feature of untreated Cushing's disease. The objective of this study was to test the hypothesis that after treatment of Cushing's disease reduces elevated cortisol, improvement in mood and related ideations are associated with increase in caudate volume. Methods In this longitudinal, interventional study of 23 patients with Cushing's disease, 24-hour urinary free cortisol, structural magnetic resonance imaging and behavioral measures were obtained prior to treatment and approximately one year after pituitary microadenomectomy. Five SCL-90-R subscales measuring change in mood, related ideations and physical symptoms were utilized. Results Partial correlations (adjusted for age and time since surgery) showed change in caudate, but not hippocampal, volume was significantly associated with change in behavioral SCL-90-R subscales, indicating selectivity for structure. Right but not left caudate showed associations, suggesting selectivity for lateralization. Right caudate volume increase was significantly associated with decreases in Depression, Anxiety, Obsessive-Compulsive, and Paranoid scores, but not with Somatization (physical symptoms), indicating specificity for behavioral but not physical variables. Limitations A limitation is that relatively low-resolution scans were utilized. Although most likely not diminishing the significant findings, less sensitive methodology could lead to an increased probability of a type 2 error. Conclusions These findings support the concept that caudate, and likely right caudate, participates in human brain circuitry regulating mood. |
| doi_str_mv | 10.1016/j.jad.2006.11.007 |
| format | Article |
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The depressive syndrome is a feature of untreated Cushing's disease. The objective of this study was to test the hypothesis that after treatment of Cushing's disease reduces elevated cortisol, improvement in mood and related ideations are associated with increase in caudate volume. Methods In this longitudinal, interventional study of 23 patients with Cushing's disease, 24-hour urinary free cortisol, structural magnetic resonance imaging and behavioral measures were obtained prior to treatment and approximately one year after pituitary microadenomectomy. Five SCL-90-R subscales measuring change in mood, related ideations and physical symptoms were utilized. Results Partial correlations (adjusted for age and time since surgery) showed change in caudate, but not hippocampal, volume was significantly associated with change in behavioral SCL-90-R subscales, indicating selectivity for structure. Right but not left caudate showed associations, suggesting selectivity for lateralization. Right caudate volume increase was significantly associated with decreases in Depression, Anxiety, Obsessive-Compulsive, and Paranoid scores, but not with Somatization (physical symptoms), indicating specificity for behavioral but not physical variables. Limitations A limitation is that relatively low-resolution scans were utilized. Although most likely not diminishing the significant findings, less sensitive methodology could lead to an increased probability of a type 2 error. Conclusions These findings support the concept that caudate, and likely right caudate, participates in human brain circuitry regulating mood.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2006.11.007</identifier><identifier>PMID: 17174404</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adenoma - diagnosis ; Adenoma - psychology ; Adenoma - surgery ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Adult and adolescent clinical studies ; Affect - physiology ; Anxiety ; Anxiety Disorders - diagnosis ; Anxiety Disorders - physiopathology ; Anxiety Disorders - psychology ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Caudate ; Caudate Nucleus - pathology ; Caudate Nucleus - physiopathology ; Cushing's ; Depression ; Depressive Disorder - diagnosis ; Depressive Disorder - physiopathology ; Depressive Disorder - psychology ; Dominance, Cerebral - physiology ; Endocrinopathies ; Female ; Hippocampus ; Hippocampus - pathology ; Humans ; Hydrocortisone - urine ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Obsessive-Compulsive Disorder - diagnosis ; Obsessive-Compulsive Disorder - physiopathology ; Obsessive-Compulsive Disorder - psychology ; Obsessive-compulsive disorders ; Obsessive-Compulsive ideation ; Personality Inventory ; Pituitary ACTH Hypersecretion - diagnosis ; Pituitary ACTH Hypersecretion - psychology ; Pituitary ACTH Hypersecretion - surgery ; Pituitary Neoplasms - diagnosis ; Pituitary Neoplasms - psychology ; Pituitary Neoplasms - surgery ; Postoperative Complications - diagnosis ; Postoperative Complications - physiopathology ; Postoperative Complications - psychology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Journal of affective disorders, 2007-08, Vol.101 (1), p.139-147</ispartof><rights>Elsevier B.V.</rights><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-daa332d3d11406c67e910975aeffcfd7fe6eb58eabbd162841461b7e5b3b541a3</citedby><cites>FETCH-LOGICAL-c436t-daa332d3d11406c67e910975aeffcfd7fe6eb58eabbd162841461b7e5b3b541a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2006.11.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18863179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17174404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Starkman, Monica N</creatorcontrib><creatorcontrib>Giordani, Bruno</creatorcontrib><creatorcontrib>Gebarski, Stephen S</creatorcontrib><creatorcontrib>Schteingart, David E</creatorcontrib><title>Improvement in mood and ideation associated with increase in right caudate volume</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background The basal ganglia, particularly caudate, are hypothesized to play a role in affective and obsessive-compulsive disorders. The depressive syndrome is a feature of untreated Cushing's disease. The objective of this study was to test the hypothesis that after treatment of Cushing's disease reduces elevated cortisol, improvement in mood and related ideations are associated with increase in caudate volume. Methods In this longitudinal, interventional study of 23 patients with Cushing's disease, 24-hour urinary free cortisol, structural magnetic resonance imaging and behavioral measures were obtained prior to treatment and approximately one year after pituitary microadenomectomy. Five SCL-90-R subscales measuring change in mood, related ideations and physical symptoms were utilized. Results Partial correlations (adjusted for age and time since surgery) showed change in caudate, but not hippocampal, volume was significantly associated with change in behavioral SCL-90-R subscales, indicating selectivity for structure. Right but not left caudate showed associations, suggesting selectivity for lateralization. Right caudate volume increase was significantly associated with decreases in Depression, Anxiety, Obsessive-Compulsive, and Paranoid scores, but not with Somatization (physical symptoms), indicating specificity for behavioral but not physical variables. Limitations A limitation is that relatively low-resolution scans were utilized. Although most likely not diminishing the significant findings, less sensitive methodology could lead to an increased probability of a type 2 error. Conclusions These findings support the concept that caudate, and likely right caudate, participates in human brain circuitry regulating mood.</description><subject>Adenoma - diagnosis</subject><subject>Adenoma - psychology</subject><subject>Adenoma - surgery</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affect - physiology</subject><subject>Anxiety</subject><subject>Anxiety Disorders - diagnosis</subject><subject>Anxiety Disorders - physiopathology</subject><subject>Anxiety Disorders - psychology</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Caudate</subject><subject>Caudate Nucleus - pathology</subject><subject>Caudate Nucleus - physiopathology</subject><subject>Cushing's</subject><subject>Depression</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - physiopathology</subject><subject>Depressive Disorder - psychology</subject><subject>Dominance, Cerebral - physiology</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Hydrocortisone - urine</subject><subject>Image Processing, Computer-Assisted</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Obsessive-Compulsive Disorder - diagnosis</subject><subject>Obsessive-Compulsive Disorder - physiopathology</subject><subject>Obsessive-Compulsive Disorder - psychology</subject><subject>Obsessive-compulsive disorders</subject><subject>Obsessive-Compulsive ideation</subject><subject>Personality Inventory</subject><subject>Pituitary ACTH Hypersecretion - diagnosis</subject><subject>Pituitary ACTH Hypersecretion - psychology</subject><subject>Pituitary ACTH Hypersecretion - surgery</subject><subject>Pituitary Neoplasms - diagnosis</subject><subject>Pituitary Neoplasms - psychology</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - physiopathology</subject><subject>Postoperative Complications - psychology</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1TAQx4Mo7tvVD-BFetFb60yTJn0IwrLourAgop5Dmkzd1LZZk_bJfntT3oMFD57mML__zPAbxl4hVAgo3w3VYFxVA8gKsQJQT9gOG8XLukH1lO0y05TAa3XGzlMaIIN7Bc_ZGSpUQoDYsa83030MB5poXgo_F1MIrjCzK7wjs_gwFyalYL1ZyBV__HKXIRvJJNro6H_eLYU1q8v94hDGdaIX7FlvxkQvT_WC_fj08fvV5_L2y_XN1eVtaQWXS-mM4bx23CEKkFYq2iPsVWOo723vVE-SuqYl03UOZd0KFBI7RU3Hu0ag4Rfs7XFuvv_3SmnRk0-WxtHMFNakFUjcQysyiEfQxpBSpF7fRz-Z-KAR9OZRDzp71JtHjaizx5x5fRq-dhO5x8RJXAbenACTrBn7aGbr0yPXtpKj2mfu_ZGjrOLgKepkPc2WnI9kF-2C_-8ZH_5J29HPPi_8RQ-UhrDGOTvWqFOtQX_bHr79GySAaBXnfwE4raVi</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Starkman, Monica N</creator><creator>Giordani, Bruno</creator><creator>Gebarski, Stephen S</creator><creator>Schteingart, David E</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Improvement in mood and ideation associated with increase in right caudate volume</title><author>Starkman, Monica N ; Giordani, Bruno ; Gebarski, Stephen S ; Schteingart, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-daa332d3d11406c67e910975aeffcfd7fe6eb58eabbd162841461b7e5b3b541a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenoma - diagnosis</topic><topic>Adenoma - psychology</topic><topic>Adenoma - surgery</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affect - physiology</topic><topic>Anxiety</topic><topic>Anxiety Disorders - diagnosis</topic><topic>Anxiety Disorders - physiopathology</topic><topic>Anxiety Disorders - psychology</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Caudate</topic><topic>Caudate Nucleus - pathology</topic><topic>Caudate Nucleus - physiopathology</topic><topic>Cushing's</topic><topic>Depression</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - physiopathology</topic><topic>Depressive Disorder - psychology</topic><topic>Dominance, Cerebral - physiology</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Hydrocortisone - urine</topic><topic>Image Processing, Computer-Assisted</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Obsessive-Compulsive Disorder - diagnosis</topic><topic>Obsessive-Compulsive Disorder - physiopathology</topic><topic>Obsessive-Compulsive Disorder - psychology</topic><topic>Obsessive-compulsive disorders</topic><topic>Obsessive-Compulsive ideation</topic><topic>Personality Inventory</topic><topic>Pituitary ACTH Hypersecretion - diagnosis</topic><topic>Pituitary ACTH Hypersecretion - psychology</topic><topic>Pituitary ACTH Hypersecretion - surgery</topic><topic>Pituitary Neoplasms - diagnosis</topic><topic>Pituitary Neoplasms - psychology</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - physiopathology</topic><topic>Postoperative Complications - psychology</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Starkman, Monica N</creatorcontrib><creatorcontrib>Giordani, Bruno</creatorcontrib><creatorcontrib>Gebarski, Stephen S</creatorcontrib><creatorcontrib>Schteingart, David E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Starkman, Monica N</au><au>Giordani, Bruno</au><au>Gebarski, Stephen S</au><au>Schteingart, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement in mood and ideation associated with increase in right caudate volume</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>101</volume><issue>1</issue><spage>139</spage><epage>147</epage><pages>139-147</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract Background The basal ganglia, particularly caudate, are hypothesized to play a role in affective and obsessive-compulsive disorders. The depressive syndrome is a feature of untreated Cushing's disease. The objective of this study was to test the hypothesis that after treatment of Cushing's disease reduces elevated cortisol, improvement in mood and related ideations are associated with increase in caudate volume. Methods In this longitudinal, interventional study of 23 patients with Cushing's disease, 24-hour urinary free cortisol, structural magnetic resonance imaging and behavioral measures were obtained prior to treatment and approximately one year after pituitary microadenomectomy. Five SCL-90-R subscales measuring change in mood, related ideations and physical symptoms were utilized. Results Partial correlations (adjusted for age and time since surgery) showed change in caudate, but not hippocampal, volume was significantly associated with change in behavioral SCL-90-R subscales, indicating selectivity for structure. Right but not left caudate showed associations, suggesting selectivity for lateralization. Right caudate volume increase was significantly associated with decreases in Depression, Anxiety, Obsessive-Compulsive, and Paranoid scores, but not with Somatization (physical symptoms), indicating specificity for behavioral but not physical variables. Limitations A limitation is that relatively low-resolution scans were utilized. Although most likely not diminishing the significant findings, less sensitive methodology could lead to an increased probability of a type 2 error. Conclusions These findings support the concept that caudate, and likely right caudate, participates in human brain circuitry regulating mood.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17174404</pmid><doi>10.1016/j.jad.2006.11.007</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenoma - diagnosis Adenoma - psychology Adenoma - surgery Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Adult and adolescent clinical studies Affect - physiology Anxiety Anxiety Disorders - diagnosis Anxiety Disorders - physiopathology Anxiety Disorders - psychology Anxiety disorders. Neuroses Biological and medical sciences Caudate Caudate Nucleus - pathology Caudate Nucleus - physiopathology Cushing's Depression Depressive Disorder - diagnosis Depressive Disorder - physiopathology Depressive Disorder - psychology Dominance, Cerebral - physiology Endocrinopathies Female Hippocampus Hippocampus - pathology Humans Hydrocortisone - urine Image Processing, Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging Male Medical sciences Middle Aged Mood disorders Non tumoral diseases. Target tissue resistance. Benign neoplasms Obsessive-Compulsive Disorder - diagnosis Obsessive-Compulsive Disorder - physiopathology Obsessive-Compulsive Disorder - psychology Obsessive-compulsive disorders Obsessive-Compulsive ideation Personality Inventory Pituitary ACTH Hypersecretion - diagnosis Pituitary ACTH Hypersecretion - psychology Pituitary ACTH Hypersecretion - surgery Pituitary Neoplasms - diagnosis Pituitary Neoplasms - psychology Pituitary Neoplasms - surgery Postoperative Complications - diagnosis Postoperative Complications - physiopathology Postoperative Complications - psychology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Improvement in mood and ideation associated with increase in right caudate volume |
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