Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker

Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter,...

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Veröffentlicht in:	Nano letters 2007-06, Vol.7 (6), p.1591-1597
Hauptverfasser:	Huang, Xiaohua, El-Sayed, Ivan H., Qian, Wei, El-Sayed, Mostafa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Cell Line, Tumor Contrast Media Cross-disciplinary physics: materials science rheology Exact sciences and technology Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Gold - chemistry Humans Immunoassay - methods Materials science Molecular Probe Techniques Nanoscale materials and structures: fabrication and characterization Nanotechnology - methods Nanotubes - chemistry Nanotubes - ultrastructure Other topics in nanoscale materials and structures Physics Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - immunology Refractometry - methods Spectrum Analysis, Raman - methods Tissues, organs and organisms biophysics
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