Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker
Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter,...
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| Veröffentlicht in: | Nano letters 2007-06, Vol.7 (6), p.1591-1597 |
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| creator | Huang, Xiaohua El-Sayed, Ivan H. Qian, Wei El-Sayed, Mostafa A. |
| description | Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells. |
| doi_str_mv | 10.1021/nl070472c |
| format | Article |
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Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells.</description><identifier>ISSN: 1530-6984</identifier><identifier>EISSN: 1530-6992</identifier><identifier>DOI: 10.1021/nl070472c</identifier><identifier>PMID: 17474783</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biological and medical sciences ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - pathology ; Cell Line, Tumor ; Contrast Media ; Cross-disciplinary physics: materials science; rheology ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; General aspects, investigation technics, apparatus ; Gold - chemistry ; Humans ; Immunoassay - methods ; Materials science ; Molecular Probe Techniques ; Nanoscale materials and structures: fabrication and characterization ; Nanotechnology - methods ; Nanotubes - chemistry ; Nanotubes - ultrastructure ; Other topics in nanoscale materials and structures ; Physics ; Receptor, Epidermal Growth Factor - chemistry ; Receptor, Epidermal Growth Factor - immunology ; Refractometry - methods ; Spectrum Analysis, Raman - methods ; Tissues, organs and organisms biophysics</subject><ispartof>Nano letters, 2007-06, Vol.7 (6), p.1591-1597</ispartof><rights>Copyright © 2007 American Chemical Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a440t-8f012f91488554e8a8f8a219aebd2b915489017e3df64bf82f42da69fab2b5f43</citedby><cites>FETCH-LOGICAL-a440t-8f012f91488554e8a8f8a219aebd2b915489017e3df64bf82f42da69fab2b5f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/nl070472c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/nl070472c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18853888$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17474783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Xiaohua</creatorcontrib><creatorcontrib>El-Sayed, Ivan H.</creatorcontrib><creatorcontrib>Qian, Wei</creatorcontrib><creatorcontrib>El-Sayed, Mostafa A.</creatorcontrib><title>Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Line, Tumor</subject><subject>Contrast Media</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects, investigation technics, apparatus</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Immunoassay - methods</subject><subject>Materials science</subject><subject>Molecular Probe Techniques</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Nanotechnology - methods</subject><subject>Nanotubes - chemistry</subject><subject>Nanotubes - ultrastructure</subject><subject>Other topics in nanoscale materials and structures</subject><subject>Physics</subject><subject>Receptor, Epidermal Growth Factor - chemistry</subject><subject>Receptor, Epidermal Growth Factor - immunology</subject><subject>Refractometry - methods</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Tissues, organs and organisms biophysics</subject><issn>1530-6984</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1u1DAUB_AIgWhpWXAB5A1ISJ3iryROd1EoLVJLKwbW0Utsz3hw7MFOFmXFlgtxIE6Ch0adDRLywrb089_2e1n2guBTgil56ywuMS9p_yg7JDnDi6Kq6OOHteAH2bMYNxjjiuX4aXZASp6GYIfZrwZcrwJqlLUR1TGqobMKgZOotmbl0IW3En0E54OXETXebaYVjEqi0aPajabz0qi4290mMfUKXZrV2t6hc7feRcsTtFxD2J78zbz1FoL5no4vp6Ah6U8wgEPLrerHAGe_f_xEdVKjStFg0fy6dwZWzsfR9OgawlcVjrMnGmxUz-f5KPvy_vxzc7m4urn40NRXC-AcjwuhMaG6IlyIPOdKgNACKKlAdZJ2Fcm5qDApFZO64J0WVHMqoag0dLTLNWdH2ev73G3w3yYVx3YwsU-1Aqf8FNsSF6RkhP0XUswKwQlO8M097IOPMSjdboMZINy1BLe7brYP3Uz25Rw6dYOSezm3L4FXM4DYg9UhlcvEvUvfZkKIvYM-ths_BZeK9o8L_wDqvLUL</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Huang, Xiaohua</creator><creator>El-Sayed, Ivan H.</creator><creator>Qian, Wei</creator><creator>El-Sayed, Mostafa A.</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker</title><author>Huang, Xiaohua ; El-Sayed, Ivan H. ; Qian, Wei ; El-Sayed, Mostafa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a440t-8f012f91488554e8a8f8a219aebd2b915489017e3df64bf82f42da69fab2b5f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Line, Tumor</topic><topic>Contrast Media</topic><topic>Cross-disciplinary physics: materials science; rheology</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects, investigation technics, apparatus</topic><topic>Gold - chemistry</topic><topic>Humans</topic><topic>Immunoassay - methods</topic><topic>Materials science</topic><topic>Molecular Probe Techniques</topic><topic>Nanoscale materials and structures: fabrication and characterization</topic><topic>Nanotechnology - methods</topic><topic>Nanotubes - chemistry</topic><topic>Nanotubes - ultrastructure</topic><topic>Other topics in nanoscale materials and structures</topic><topic>Physics</topic><topic>Receptor, Epidermal Growth Factor - chemistry</topic><topic>Receptor, Epidermal Growth Factor - immunology</topic><topic>Refractometry - methods</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Xiaohua</creatorcontrib><creatorcontrib>El-Sayed, Ivan H.</creatorcontrib><creatorcontrib>Qian, Wei</creatorcontrib><creatorcontrib>El-Sayed, Mostafa A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nano letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Xiaohua</au><au>El-Sayed, Ivan H.</au><au>Qian, Wei</au><au>El-Sayed, Mostafa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>7</volume><issue>6</issue><spage>1591</spage><epage>1597</epage><pages>1591-1597</pages><issn>1530-6984</issn><eissn>1530-6992</eissn><abstract>Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>17474783</pmid><doi>10.1021/nl070472c</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Cell Line, Tumor Contrast Media Cross-disciplinary physics: materials science rheology Exact sciences and technology Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Gold - chemistry Humans Immunoassay - methods Materials science Molecular Probe Techniques Nanoscale materials and structures: fabrication and characterization Nanotechnology - methods Nanotubes - chemistry Nanotubes - ultrastructure Other topics in nanoscale materials and structures Physics Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - immunology Refractometry - methods Spectrum Analysis, Raman - methods Tissues, organs and organisms biophysics |
| title | Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker |
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