Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection
Objectives We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally. Methods Mice were treated with voriconazole at 10, 40 or 60 mg/kg/day orally or with amphoteric...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2007-07, Vol.60 (1), p.162-165 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Serena, Carolina Pastor, F. Javier Mariné, Marçal Rodríguez, M. Mar Guarro, Josep |
| description | Objectives We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally. Methods Mice were treated with voriconazole at 10, 40 or 60 mg/kg/day orally or with amphotericin B at 1.5 mg/kg/day intraperitoneally. Treatment began 1 day after infection and continued for 10 days post-infection. Tissue burden studies were performed on day 7 and 1 day after the treatment finished. Results Both drugs were able to significantly prolong survival with respect to the control group. The highest tissue burden reduction was achieved with voriconazole at 60 mg/kg/day. Conclusions We have developed a murine model of cryptococcal central nervous system infection and demonstrated that voriconazole has a potential for the treatment of cryptococcosis. |
| doi_str_mv | 10.1093/jac/dkm123 |
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Javier ; Mariné, Marçal ; Rodríguez, M. Mar ; Guarro, Josep</creator><creatorcontrib>Serena, Carolina ; Pastor, F. Javier ; Mariné, Marçal ; Rodríguez, M. Mar ; Guarro, Josep</creatorcontrib><description>Objectives We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally. Methods Mice were treated with voriconazole at 10, 40 or 60 mg/kg/day orally or with amphotericin B at 1.5 mg/kg/day intraperitoneally. Treatment began 1 day after infection and continued for 10 days post-infection. Tissue burden studies were performed on day 7 and 1 day after the treatment finished. Results Both drugs were able to significantly prolong survival with respect to the control group. The highest tissue burden reduction was achieved with voriconazole at 60 mg/kg/day. Conclusions We have developed a murine model of cryptococcal central nervous system infection and demonstrated that voriconazole has a potential for the treatment of cryptococcosis.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkm123</identifier><identifier>PMID: 17483143</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>amphotericin B ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Brain - microbiology ; Central Nervous System Fungal Infections - drug therapy ; Central Nervous System Fungal Infections - microbiology ; Central Nervous System Fungal Infections - mortality ; Comparative studies ; Cryptococcosis - drug therapy ; Cryptococcosis - microbiology ; Cryptococcosis - mortality ; Cryptococcus neoformans ; Cryptococcus neoformans - drug effects ; Disease Models, Animal ; Human mycoses ; Humans ; Infections ; Infectious diseases ; intracranial murine model ; Lung - microbiology ; Male ; Medical research ; Medical sciences ; Mice ; Microbiology ; Miscellaneous mycoses ; Mycoses ; Pharmacology. Drug treatments ; Pyrimidines - therapeutic use ; Rodents ; Treatment Outcome ; Triazoles - therapeutic use ; Voriconazole</subject><ispartof>Journal of antimicrobial chemotherapy, 2007-07, Vol.60 (1), p.162-165</ispartof><rights>The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-230f8b117ab5d08ecb5613539837a9d75c72d54a9021561b051d1f64874624553</citedby><cites>FETCH-LOGICAL-c441t-230f8b117ab5d08ecb5613539837a9d75c72d54a9021561b051d1f64874624553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18866830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17483143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serena, Carolina</creatorcontrib><creatorcontrib>Pastor, F. Javier</creatorcontrib><creatorcontrib>Mariné, Marçal</creatorcontrib><creatorcontrib>Rodríguez, M. Mar</creatorcontrib><creatorcontrib>Guarro, Josep</creatorcontrib><title>Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally. Methods Mice were treated with voriconazole at 10, 40 or 60 mg/kg/day orally or with amphotericin B at 1.5 mg/kg/day intraperitoneally. Treatment began 1 day after infection and continued for 10 days post-infection. Tissue burden studies were performed on day 7 and 1 day after the treatment finished. Results Both drugs were able to significantly prolong survival with respect to the control group. The highest tissue burden reduction was achieved with voriconazole at 60 mg/kg/day. Conclusions We have developed a murine model of cryptococcal central nervous system infection and demonstrated that voriconazole has a potential for the treatment of cryptococcosis.</description><subject>amphotericin B</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain - microbiology</subject><subject>Central Nervous System Fungal Infections - drug therapy</subject><subject>Central Nervous System Fungal Infections - microbiology</subject><subject>Central Nervous System Fungal Infections - mortality</subject><subject>Comparative studies</subject><subject>Cryptococcosis - drug therapy</subject><subject>Cryptococcosis - microbiology</subject><subject>Cryptococcosis - mortality</subject><subject>Cryptococcus neoformans</subject><subject>Cryptococcus neoformans - drug effects</subject><subject>Disease Models, Animal</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>intracranial murine model</subject><subject>Lung - microbiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Miscellaneous mycoses</subject><subject>Mycoses</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrimidines - therapeutic use</subject><subject>Rodents</subject><subject>Treatment Outcome</subject><subject>Triazoles - therapeutic use</subject><subject>Voriconazole</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9rFDEUB_AgFbtWL_4BMgh6KEybN_k5Rym1LSwtVAWph5DJJJDtTLJNZorrX2_KLi54sKd3yCcvee-L0DvAJ4BbcrrS5rS_H6EhL9ACKMd1g1s4QAtMMKsFZeQQvc55hTHmjMtX6BAElQQoWaCf5855o82miq56jMmbGPTvONjKh0pX45x8sNUYezs8CZM26ymaaIweKmPDlEoNNj3GOVd5kyc7lovOmsnH8Aa9dHrI9u2uHqHvX86_nV3Wy5uLq7PPy9pQClPdEOxkByB0x3osrekYB8JIK4nQbS-YEU3PqG5xA-Wkwwx6cJxKQXlDGSNH6NO27zrFh9nmSY0-GzsMOtjyLyUwBwFlPc9BaHkLrBEFfvgHruKcQhlCNSB42R6nBR1vkUkx52SdWic_6rRRgNVTMKoEo7bBFPx-13HuRtvv6S6JAj7ugM5luS7pYHzeOyk5lwTvXZzX_3-w3jpfQvn1V-p0r7gggqnLH3fqQsDd8ustU9fkD4EVsMI</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Serena, Carolina</creator><creator>Pastor, F. Javier</creator><creator>Mariné, Marçal</creator><creator>Rodríguez, M. Mar</creator><creator>Guarro, Josep</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection</title><author>Serena, Carolina ; Pastor, F. Javier ; Mariné, Marçal ; Rodríguez, M. Mar ; Guarro, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-230f8b117ab5d08ecb5613539837a9d75c72d54a9021561b051d1f64874624553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>amphotericin B</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain - microbiology</topic><topic>Central Nervous System Fungal Infections - drug therapy</topic><topic>Central Nervous System Fungal Infections - microbiology</topic><topic>Central Nervous System Fungal Infections - mortality</topic><topic>Comparative studies</topic><topic>Cryptococcosis - drug therapy</topic><topic>Cryptococcosis - microbiology</topic><topic>Cryptococcosis - mortality</topic><topic>Cryptococcus neoformans</topic><topic>Cryptococcus neoformans - drug effects</topic><topic>Disease Models, Animal</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>intracranial murine model</topic><topic>Lung - microbiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Miscellaneous mycoses</topic><topic>Mycoses</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrimidines - therapeutic use</topic><topic>Rodents</topic><topic>Treatment Outcome</topic><topic>Triazoles - therapeutic use</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serena, Carolina</creatorcontrib><creatorcontrib>Pastor, F. Javier</creatorcontrib><creatorcontrib>Mariné, Marçal</creatorcontrib><creatorcontrib>Rodríguez, M. 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Javier</au><au>Mariné, Marçal</au><au>Rodríguez, M. Mar</au><au>Guarro, Josep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>60</volume><issue>1</issue><spage>162</spage><epage>165</epage><pages>162-165</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally. Methods Mice were treated with voriconazole at 10, 40 or 60 mg/kg/day orally or with amphotericin B at 1.5 mg/kg/day intraperitoneally. Treatment began 1 day after infection and continued for 10 days post-infection. Tissue burden studies were performed on day 7 and 1 day after the treatment finished. Results Both drugs were able to significantly prolong survival with respect to the control group. The highest tissue burden reduction was achieved with voriconazole at 60 mg/kg/day. Conclusions We have developed a murine model of cryptococcal central nervous system infection and demonstrated that voriconazole has a potential for the treatment of cryptococcosis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17483143</pmid><doi>10.1093/jac/dkm123</doi><tpages>4</tpages></addata></record> |
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| subjects | amphotericin B Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - therapeutic use Biological and medical sciences Brain - microbiology Central Nervous System Fungal Infections - drug therapy Central Nervous System Fungal Infections - microbiology Central Nervous System Fungal Infections - mortality Comparative studies Cryptococcosis - drug therapy Cryptococcosis - microbiology Cryptococcosis - mortality Cryptococcus neoformans Cryptococcus neoformans - drug effects Disease Models, Animal Human mycoses Humans Infections Infectious diseases intracranial murine model Lung - microbiology Male Medical research Medical sciences Mice Microbiology Miscellaneous mycoses Mycoses Pharmacology. Drug treatments Pyrimidines - therapeutic use Rodents Treatment Outcome Triazoles - therapeutic use Voriconazole |
| title | Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection |
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