Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system
The relationship between the development of the enteric nervous system and interstitial cells of Cajal (ICC) in the human small intestine was investigated in a full-term infant who presented with intestinal pseudo-obstruction. Immunohistochemistry revealed absence of enteric nerves and ganglia but a...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2001-02, Vol.120 (2), p.561-567 |
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| creator | Huizinga, Jan D. Berezin, Irene Sircar, Kanishka Hewlett, Bryan Donnelly, Graeme Bercik, Premysl Ross, Catherine Algofi, Talal Fitzgerald, Peter Der, Tara Riddell, Robert H. Collins, Stephen M. Jacobson, Kevan |
| description | The relationship between the development of the enteric nervous system and interstitial cells of Cajal (ICC) in the human small intestine was investigated in a full-term infant who presented with intestinal pseudo-obstruction. Immunohistochemistry revealed absence of enteric nerves and ganglia but abundant c-Kit immunoreactivity associated with Auerbach's plexus (ICC-AP). However, c-Kit immunoreactivity associated with the deep muscular plexus (ICC-DMP) and intermuscular ICC was absent. Electron microscopy showed ICC-AP with a normal ultrastructure; ICC-DMP were seen but were severely injured, suggesting degeneration. In vitro recording of intestinal muscle showed slow wave activity as well as response to cholinergic stimulation. Fluoroscopic examination of the small bowel showed a variety of motor patterns, including rhythmic, propagating contractions. In conclusion, total absence of enteric nerves was associated with absence of normal ICC-DMP. However, a normal musculature, including a network of ICC-AP, allowed for generation of rhythmic, propagating contractile activity, suggesting the presence of functional motor activity.
GASTROENTEROLOGY 2001;120:561-567 |
| doi_str_mv | 10.1053/gast.2001.21200 |
| format | Article |
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GASTROENTEROLOGY 2001;120:561-567</description><subject>Biological and medical sciences</subject><subject>Biological Clocks - physiology</subject><subject>Digestive system</subject><subject>Enteric Nervous System - abnormalities</subject><subject>Enteric Nervous System - ultrastructure</subject><subject>Fatal Outcome</subject><subject>Gastric Emptying - physiology</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intestine, Small - cytology</subject><subject>Intestine, Small - embryology</subject><subject>Intestine, Small - innervation</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Potentials - physiology</subject><subject>Microscopy, Electron</subject><subject>Motor Neurons - physiology</subject><subject>Muscle, Smooth - innervation</subject><subject>Muscle, Smooth - physiology</subject><subject>Muscle, Smooth - ultrastructure</subject><subject>Pathology. 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Miscellaneous investigative techniques</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlbP3iQgeNs22d3sJkepn1DwoueQzU40ZT9qkq3035u1RU-eXmZ4Zph5ELqkZE4Jyxbvyod5SgidpzTGEZpSlvIkNtJjNI1RJIxwNkFn3q8JISLj9BRNKKVMcFFOUXUHW2j6TQtdwL3BtgvgfLDBqgZraBo_dpdqHUvbYYXN0DRJZNpYGhWHvmz46IeAVYdhHLYad-C2_eCx3_kA7Tk6MarxcHHIGXp7uH9dPiWrl8fn5e0q0XnJQwJgCkOqKstJlZaKV4pnlBMtqrRiplYlqwWHrGA6ZUwLlrJCa84VFbRgdc6yGbrZ7924_nMAH2Rr_fiC6iBeI0tS0CLPyggu9qB2vfcOjNw42yq3k5TIUasctcpRq_zRGieuDquHqoX6jz94jMD1AVBeq8Y41WnrfzlBcy54pMSegqhha8FJry10GmrrQAdZ9_bfE74BVKiUYA</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Huizinga, Jan D.</creator><creator>Berezin, Irene</creator><creator>Sircar, Kanishka</creator><creator>Hewlett, Bryan</creator><creator>Donnelly, Graeme</creator><creator>Bercik, Premysl</creator><creator>Ross, Catherine</creator><creator>Algofi, Talal</creator><creator>Fitzgerald, Peter</creator><creator>Der, Tara</creator><creator>Riddell, Robert H.</creator><creator>Collins, Stephen M.</creator><creator>Jacobson, Kevan</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system</title><author>Huizinga, Jan D. ; Berezin, Irene ; Sircar, Kanishka ; Hewlett, Bryan ; Donnelly, Graeme ; Bercik, Premysl ; Ross, Catherine ; Algofi, Talal ; Fitzgerald, Peter ; Der, Tara ; Riddell, Robert H. ; Collins, Stephen M. ; Jacobson, Kevan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-eef6f0bb340b27a8ba83180c9b2b5fda75d98e365c255c95256cc88a19165d453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Biological Clocks - physiology</topic><topic>Digestive system</topic><topic>Enteric Nervous System - abnormalities</topic><topic>Enteric Nervous System - ultrastructure</topic><topic>Fatal Outcome</topic><topic>Gastric Emptying - physiology</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intestine, Small - cytology</topic><topic>Intestine, Small - embryology</topic><topic>Intestine, Small - innervation</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Potentials - physiology</topic><topic>Microscopy, Electron</topic><topic>Motor Neurons - physiology</topic><topic>Muscle, Smooth - innervation</topic><topic>Muscle, Smooth - physiology</topic><topic>Muscle, Smooth - ultrastructure</topic><topic>Pathology. 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Immunohistochemistry revealed absence of enteric nerves and ganglia but abundant c-Kit immunoreactivity associated with Auerbach's plexus (ICC-AP). However, c-Kit immunoreactivity associated with the deep muscular plexus (ICC-DMP) and intermuscular ICC was absent. Electron microscopy showed ICC-AP with a normal ultrastructure; ICC-DMP were seen but were severely injured, suggesting degeneration. In vitro recording of intestinal muscle showed slow wave activity as well as response to cholinergic stimulation. Fluoroscopic examination of the small bowel showed a variety of motor patterns, including rhythmic, propagating contractions. In conclusion, total absence of enteric nerves was associated with absence of normal ICC-DMP. However, a normal musculature, including a network of ICC-AP, allowed for generation of rhythmic, propagating contractile activity, suggesting the presence of functional motor activity.
GASTROENTEROLOGY 2001;120:561-567</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11159897</pmid><doi>10.1053/gast.2001.21200</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Biological Clocks - physiology Digestive system Enteric Nervous System - abnormalities Enteric Nervous System - ultrastructure Fatal Outcome Gastric Emptying - physiology Gastrointestinal Motility - physiology Humans Infant, Newborn Intestine, Small - cytology Intestine, Small - embryology Intestine, Small - innervation Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Membrane Potentials - physiology Microscopy, Electron Motor Neurons - physiology Muscle, Smooth - innervation Muscle, Smooth - physiology Muscle, Smooth - ultrastructure Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques |
| title | Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system |
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