Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian
Transcriptional control during early Drosophila development is governed by maternal and zygotic factors. We have identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an HMG1 (AT-hook) motif and a domain with similarity to the human fragile X mental retardat...
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| Veröffentlicht in: | Development (Cambridge) 2001-03, Vol.128 (5), p.801-813 |
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| creator | Tang, A H Neufeld, T P Rubin, G M Müller, H A |
| description | Transcriptional control during early Drosophila development is governed by maternal and zygotic factors. We have identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an HMG1 (AT-hook) motif and a domain with similarity to the human fragile X mental retardation FMR2 protein and the AF4 proto-oncoprotein. Embryos lacking maternal lilli expression show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha, fushi tarazu and huckebein, which are essential for cellularization and embryonic patterning. In addition, loss of lilli in adult photoreceptor and bristle cells results in a significant decrease in cell size. Our results indicate that lilli represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis. |
| doi_str_mv | 10.1242/dev.128.5.801 |
| format | Article |
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We have identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an HMG1 (AT-hook) motif and a domain with similarity to the human fragile X mental retardation FMR2 protein and the AF4 proto-oncoprotein. Embryos lacking maternal lilli expression show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha, fushi tarazu and huckebein, which are essential for cellularization and embryonic patterning. In addition, loss of lilli in adult photoreceptor and bristle cells results in a significant decrease in cell size. Our results indicate that lilli represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.128.5.801</identifier><identifier>PMID: 11171404</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Actins - metabolism ; Amino Acid Sequence ; Animals ; Body Patterning ; Cell Size ; Cytoskeleton - genetics ; Cytoskeleton - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drosophila ; Drosophila melanogaster - embryology ; Drosophila melanogaster - genetics ; Drosophila Proteins ; Embryo, Nonmammalian - cytology ; Embryo, Nonmammalian - physiology ; Female ; Flow Cytometry ; fushi tarazu gene ; Fushi Tarazu Transcription Factors ; Gene Expression Regulation, Developmental ; Genes, Insect ; Genes, Reporter - genetics ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; huckebein gene ; Humans ; In Situ Hybridization ; lilliputian (lilli) gene ; Male ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Microscopy, Confocal ; Microscopy, Fluorescence ; Microscopy, Video ; Microtubules - metabolism ; Molecular Sequence Data ; Nuclear Proteins - chemistry ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Photoreceptor Cells, Invertebrate - cytology ; Photoreceptor Cells, Invertebrate - embryology ; Photoreceptor Cells, Invertebrate - metabolism ; RNA, Messenger - metabolism ; Sequence Alignment ; serendipity gene ; Transcription Factors ; Wings, Animal - anatomy & histology</subject><ispartof>Development (Cambridge), 2001-03, Vol.128 (5), p.801-813</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-de5ea5f1762026970cc91f395fc754fe5b4399fb063b47676657f2adb38f980c3</citedby><cites>FETCH-LOGICAL-c423t-de5ea5f1762026970cc91f395fc754fe5b4399fb063b47676657f2adb38f980c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3665,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11171404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, A H</creatorcontrib><creatorcontrib>Neufeld, T P</creatorcontrib><creatorcontrib>Rubin, G M</creatorcontrib><creatorcontrib>Müller, H A</creatorcontrib><title>Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>Transcriptional control during early Drosophila development is governed by maternal and zygotic factors. We have identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an HMG1 (AT-hook) motif and a domain with similarity to the human fragile X mental retardation FMR2 protein and the AF4 proto-oncoprotein. Embryos lacking maternal lilli expression show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha, fushi tarazu and huckebein, which are essential for cellularization and embryonic patterning. In addition, loss of lilli in adult photoreceptor and bristle cells results in a significant decrease in cell size. Our results indicate that lilli represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis.</description><subject>Actins - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Body Patterning</subject><subject>Cell Size</subject><subject>Cytoskeleton - genetics</subject><subject>Cytoskeleton - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>fushi tarazu gene</subject><subject>Fushi Tarazu Transcription Factors</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Insect</subject><subject>Genes, Reporter - genetics</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>huckebein gene</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>lilliputian (lilli) gene</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Microscopy, Confocal</subject><subject>Microscopy, Fluorescence</subject><subject>Microscopy, Video</subject><subject>Microtubules - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - chemistry</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Photoreceptor Cells, Invertebrate - cytology</subject><subject>Photoreceptor Cells, Invertebrate - embryology</subject><subject>Photoreceptor Cells, Invertebrate - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Alignment</subject><subject>serendipity gene</subject><subject>Transcription Factors</subject><subject>Wings, Animal - anatomy & histology</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTuP1DAUhS0EYoeFkha5otoMduJHXKLV8pBWollqy3GuswbHDrazaP49iWYk6KjuuTqfvuYg9JaSI21Z-2GEpy30R37sCX2GDpRJ2SjaqufoQBQnDVWKXqFXpfwghHRCypfoilIqKSPsgNaHbGKx2S_Vp2gCzjCtwewPTg7bU03lJwSoW-XWaPeiYBNHXGCaIdYzOpywwTE9QcCzqZB302J8bvIaAE8Q4QYHH4Jf1upNfI1eOBMKvLnca_T9093D7Zfm_tvnr7cf7xvL2q42I3Aw3FEpWtIKJYm1irpOcWclZw74wDql3EBENzAppBBcutaMQ9c71RPbXaP3Z--S068VStWzLxZCMBHSWrQkgjLByX9BKnumFFcb2JxBm1MpGZxesp9NPmlK9D6I3gbZQq-53gbZ-HcX8TrMMP6lLwtswM0ZePTT42-fQQ8-hTT5UsvugpCWf3x_AM4hmM4</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Tang, A H</creator><creator>Neufeld, T P</creator><creator>Rubin, G M</creator><creator>Müller, H A</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian</title><author>Tang, A H ; Neufeld, T P ; Rubin, G M ; Müller, H A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-de5ea5f1762026970cc91f395fc754fe5b4399fb063b47676657f2adb38f980c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Actins - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Body Patterning</topic><topic>Cell Size</topic><topic>Cytoskeleton - genetics</topic><topic>Cytoskeleton - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins</topic><topic>Embryo, Nonmammalian - cytology</topic><topic>Embryo, Nonmammalian - physiology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>fushi tarazu gene</topic><topic>Fushi Tarazu Transcription Factors</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Insect</topic><topic>Genes, Reporter - genetics</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>huckebein gene</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>lilliputian (lilli) gene</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Microscopy, Confocal</topic><topic>Microscopy, Fluorescence</topic><topic>Microscopy, Video</topic><topic>Microtubules - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - chemistry</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Photoreceptor Cells, Invertebrate - cytology</topic><topic>Photoreceptor Cells, Invertebrate - embryology</topic><topic>Photoreceptor Cells, Invertebrate - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>serendipity gene</topic><topic>Transcription Factors</topic><topic>Wings, Animal - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, A H</creatorcontrib><creatorcontrib>Neufeld, T P</creatorcontrib><creatorcontrib>Rubin, G M</creatorcontrib><creatorcontrib>Müller, H A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, A H</au><au>Neufeld, T P</au><au>Rubin, G M</au><au>Müller, H A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>128</volume><issue>5</issue><spage>801</spage><epage>813</epage><pages>801-813</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>Transcriptional control during early Drosophila development is governed by maternal and zygotic factors. We have identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an HMG1 (AT-hook) motif and a domain with similarity to the human fragile X mental retardation FMR2 protein and the AF4 proto-oncoprotein. Embryos lacking maternal lilli expression show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha, fushi tarazu and huckebein, which are essential for cellularization and embryonic patterning. In addition, loss of lilli in adult photoreceptor and bristle cells results in a significant decrease in cell size. Our results indicate that lilli represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>11171404</pmid><doi>10.1242/dev.128.5.801</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; The Company of Biologists; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Actins - metabolism Amino Acid Sequence Animals Body Patterning Cell Size Cytoskeleton - genetics Cytoskeleton - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology Female Flow Cytometry fushi tarazu gene Fushi Tarazu Transcription Factors Gene Expression Regulation, Developmental Genes, Insect Genes, Reporter - genetics Homeodomain Proteins - genetics Homeodomain Proteins - metabolism huckebein gene Humans In Situ Hybridization lilliputian (lilli) gene Male Membrane Proteins - genetics Membrane Proteins - metabolism Microscopy, Confocal Microscopy, Fluorescence Microscopy, Video Microtubules - metabolism Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Photoreceptor Cells, Invertebrate - cytology Photoreceptor Cells, Invertebrate - embryology Photoreceptor Cells, Invertebrate - metabolism RNA, Messenger - metabolism Sequence Alignment serendipity gene Transcription Factors Wings, Animal - anatomy & histology |
| title | Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian |
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