Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant γ-aminobutyric acid type-A receptors

Anesthetics produce immobility and depress spinal nociceptive processing, but the exact sites and mechanisms of anesthetic action are unknown. The gamma-aminobutyric acid type-A (GABA A) receptor is thought to be important to anesthetic action. We studied knock-in mice that had mutations in the alph...

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Veröffentlicht in:	Neuroscience letters 2007-06, Vol.420 (3), p.209-212
Hauptverfasser:	Kim, JongBun, Atherley, Richard, Werner, David F., Homanics, Gregg E., Carstens, Earl, Antognini, Joseph F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthetics, Inhalation - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Depression, Chemical Dose-Response Relationship, Drug Drug Resistance Electric Stimulation Electrophysiology Female Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology GABA receptor Immobility Isoflurane Isoflurane - pharmacology Male Medical sciences Mice Mutation - physiology Neurons - drug effects Neurons - physiology Neuropharmacology Nociceptors - drug effects Pain - physiopathology Pharmacology. Drug treatments Physical Stimulation Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Receptors, GABA-A - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Spinal Cord - cytology Spinal Cord - drug effects Stereotaxic Techniques Vertebrates: nervous system and sense organs
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