Development and validation of a stability-indicating liquid chromatographic method for determination of emtricitabine and related impurities in drug substance

A novel stability‐indicating high‐performance liquid chromatographic (HPLC) method was developed and validated for assay and determination of impurities of emtricitabine in drug substance. Emtricitabine was found to be degraded under acidic, alkaline, and oxidative stress conditions and to be more l...

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Veröffentlicht in:	Journal of separation science 2007-05, Vol.30 (7), p.999-1004
Hauptverfasser:	Seshachalam, Unnam, Haribabu, Bodepudi, Chandrasekhar, Kottapalli B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Chromatography, High Pressure Liquid - methods Deoxycytidine - analogs & derivatives Deoxycytidine - analysis Drug Contamination Drug substance Emtricitabine Forced degradation General pharmacology HPLC Medical sciences Molecular Structure Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Sensitivity and Specificity Solid state stability Stereoisomerism
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