Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation
Abstract The regulation of fluid and electrolyte homeostasis involves the participation of several neuropeptides and hormones that utilize hypothalamic cholinergic, alpha-adrenergic and angiotensinergic neurotransmitters and pathways. Additionally, it has been suggested that hypothalamus–pituitary–a...
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| creator | Lauand, F Ruginsk, S.G Rodrigues, H.L.P Reis, W.L de Castro, M Elias, L.L.K Antunes-Rodrigues, J |
| description | Abstract The regulation of fluid and electrolyte homeostasis involves the participation of several neuropeptides and hormones that utilize hypothalamic cholinergic, alpha-adrenergic and angiotensinergic neurotransmitters and pathways. Additionally, it has been suggested that hypothalamus–pituitary–adrenal axis activity modulates hormonal responses to blood volume expansion. In the present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0.30 M NaCl, angiotensin-II (ANG-II) and carbachol. We also evaluated the Fos protein immunoreactivity in the median preoptic (MnPO), paraventricular (PVN) and supraoptic (SON) nuclei. Male Wistar rats received an i.p. injection of dexamethasone (1 mg/kg) or vehicle (0.15 M NaCl) 2 h before the i.c.v. microinjections. Blood samples for plasma ANP, OT, AVP and corticosterone determinations were collected at 5 and 20 min after stimulus. Another set of rats was perfused 120 min after stimulation. A significant increase in plasma ANP, OT, AVP and corticosterone levels was observed at 5 and 20 min after each central stimulation compared with isotonic saline–injected group. Pre-treatment with dexamethasone decreased plasma corticosterone and OT levels, with no changes in the AVP secretion. On the other hand, dexamethasone induced a significant increase in plasma ANP levels. A significant increase in the number of Fos immunoreactive neurons was observed in the MnPO, PVN and SON after i.c.v. stimulations. Pre-treatment with dexamethasone induced a significant decrease in Fos immunoreactivity in these nuclei compared with the vehicle. These results indicate that central osmotic, cholinergic, and angiotensinergic stimuli activate MnPO, PVN and SON, with a subsequent OT, AVP, and ANP release. The present data also suggest that these responses are modulated by glucocorticoids. |
| doi_str_mv | 10.1016/j.neuroscience.2007.04.021 |
| format | Article |
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Additionally, it has been suggested that hypothalamus–pituitary–adrenal axis activity modulates hormonal responses to blood volume expansion. In the present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0.30 M NaCl, angiotensin-II (ANG-II) and carbachol. We also evaluated the Fos protein immunoreactivity in the median preoptic (MnPO), paraventricular (PVN) and supraoptic (SON) nuclei. Male Wistar rats received an i.p. injection of dexamethasone (1 mg/kg) or vehicle (0.15 M NaCl) 2 h before the i.c.v. microinjections. Blood samples for plasma ANP, OT, AVP and corticosterone determinations were collected at 5 and 20 min after stimulus. Another set of rats was perfused 120 min after stimulation. A significant increase in plasma ANP, OT, AVP and corticosterone levels was observed at 5 and 20 min after each central stimulation compared with isotonic saline–injected group. Pre-treatment with dexamethasone decreased plasma corticosterone and OT levels, with no changes in the AVP secretion. On the other hand, dexamethasone induced a significant increase in plasma ANP levels. A significant increase in the number of Fos immunoreactive neurons was observed in the MnPO, PVN and SON after i.c.v. stimulations. Pre-treatment with dexamethasone induced a significant decrease in Fos immunoreactivity in these nuclei compared with the vehicle. These results indicate that central osmotic, cholinergic, and angiotensinergic stimuli activate MnPO, PVN and SON, with a subsequent OT, AVP, and ANP release. The present data also suggest that these responses are modulated by glucocorticoids.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2007.04.021</identifier><identifier>PMID: 17524563</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adaptation, Physiological ; ANG-II ; Angiotensin II - physiology ; Animals ; ANP ; Atrial Natriuretic Factor - blood ; Atrial Natriuretic Factor - drug effects ; Biological and medical sciences ; carbachol ; Carbachol - pharmacology ; Cholinergic Agonists - pharmacology ; Corticosterone - blood ; Dexamethasone - pharmacology ; Fundamental and applied biological sciences. Psychology ; glucocorticoids ; Glucocorticoids - pharmacology ; hypothalamus ; Hypothalamus - cytology ; Hypothalamus - drug effects ; Hypothalamus - physiology ; Injections, Intraventricular ; Male ; neurohypophysial hormones ; Neurology ; Oxytocin - blood ; Oxytocin - drug effects ; Proto-Oncogene Proteins c-fos - drug effects ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Wistar ; Stimulation, Chemical ; Vasopressins - blood ; Vasopressins - drug effects ; Vertebrates: nervous system and sense organs ; Water-Electrolyte Balance - physiology</subject><ispartof>Neuroscience, 2007-06, Vol.147 (1), p.247-257</ispartof><rights>IBRO</rights><rights>2007 IBRO</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-3fa684005af24da2167c90892075f73bad1b7df1ebfc6599bc99a0da1879de5b3</citedby><cites>FETCH-LOGICAL-c494t-3fa684005af24da2167c90892075f73bad1b7df1ebfc6599bc99a0da1879de5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452207004885$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18867471$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17524563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lauand, F</creatorcontrib><creatorcontrib>Ruginsk, S.G</creatorcontrib><creatorcontrib>Rodrigues, H.L.P</creatorcontrib><creatorcontrib>Reis, W.L</creatorcontrib><creatorcontrib>de Castro, M</creatorcontrib><creatorcontrib>Elias, L.L.K</creatorcontrib><creatorcontrib>Antunes-Rodrigues, J</creatorcontrib><title>Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract The regulation of fluid and electrolyte homeostasis involves the participation of several neuropeptides and hormones that utilize hypothalamic cholinergic, alpha-adrenergic and angiotensinergic neurotransmitters and pathways. Additionally, it has been suggested that hypothalamus–pituitary–adrenal axis activity modulates hormonal responses to blood volume expansion. In the present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0.30 M NaCl, angiotensin-II (ANG-II) and carbachol. We also evaluated the Fos protein immunoreactivity in the median preoptic (MnPO), paraventricular (PVN) and supraoptic (SON) nuclei. Male Wistar rats received an i.p. injection of dexamethasone (1 mg/kg) or vehicle (0.15 M NaCl) 2 h before the i.c.v. microinjections. Blood samples for plasma ANP, OT, AVP and corticosterone determinations were collected at 5 and 20 min after stimulus. Another set of rats was perfused 120 min after stimulation. A significant increase in plasma ANP, OT, AVP and corticosterone levels was observed at 5 and 20 min after each central stimulation compared with isotonic saline–injected group. Pre-treatment with dexamethasone decreased plasma corticosterone and OT levels, with no changes in the AVP secretion. On the other hand, dexamethasone induced a significant increase in plasma ANP levels. A significant increase in the number of Fos immunoreactive neurons was observed in the MnPO, PVN and SON after i.c.v. stimulations. Pre-treatment with dexamethasone induced a significant decrease in Fos immunoreactivity in these nuclei compared with the vehicle. These results indicate that central osmotic, cholinergic, and angiotensinergic stimuli activate MnPO, PVN and SON, with a subsequent OT, AVP, and ANP release. The present data also suggest that these responses are modulated by glucocorticoids.</description><subject>Adaptation, Physiological</subject><subject>ANG-II</subject><subject>Angiotensin II - physiology</subject><subject>Animals</subject><subject>ANP</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Atrial Natriuretic Factor - drug effects</subject><subject>Biological and medical sciences</subject><subject>carbachol</subject><subject>Carbachol - pharmacology</subject><subject>Cholinergic Agonists - pharmacology</subject><subject>Corticosterone - blood</subject><subject>Dexamethasone - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glucocorticoids</subject><subject>Glucocorticoids - pharmacology</subject><subject>hypothalamus</subject><subject>Hypothalamus - cytology</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - physiology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>neurohypophysial hormones</subject><subject>Neurology</subject><subject>Oxytocin - blood</subject><subject>Oxytocin - drug effects</subject><subject>Proto-Oncogene Proteins c-fos - drug effects</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stimulation, Chemical</subject><subject>Vasopressins - blood</subject><subject>Vasopressins - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Water-Electrolyte Balance - physiology</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEotvCKyALCU6bxU6cOOFQCRVakCpxAM6WY0-Kl8QTbKfqvhDPWUcbVMQFfBl79M0_Y__OspeM7hhl9Zv9zsHsMWgLTsOuoFTsKN_Rgj3KNqwRZS4qzh9nG1rSOudVUZxkpyHsaVoVL59mJ0xUBa_qcpP9uhpmjRp9tBqtISOaeVDRoiPYExW9VQNxS5w9JIZMMEVrYEvw7hBRW7cltyrg5CEE64hyhlxiIHB3zCSdlE3bCV0AEpFgGDEJbRN6YzGCS2Xgb5L0Uqu_4_D7HKId12GeZU96NQR4vsaz7Nvlh68XH_Prz1efLt5d55q3POZlr-qGp1uqvuBGFawWuqVNW1BR9aLslGGdMD2Drtd11badbltFjUqP1hqouvIse33UnTz-nCFEOdqgYRiUA5yDFLRmtObVP0HWCsbrpkng2yOok2PBQy8nb0flD5JRudgp9_JPO-Vip6RcJjtT8Yu1y9yNYB5KV_8S8GoFVNBq6L1y2oYHrmlqwcUi9P7IQXq8Wwteru2M9aCjNGj_b57zv2R0csumzj_gAGGPs3fJHslkKCSVX5YPuPw_KijlTVOV9xl-36Q</recordid><startdate>20070615</startdate><enddate>20070615</enddate><creator>Lauand, F</creator><creator>Ruginsk, S.G</creator><creator>Rodrigues, H.L.P</creator><creator>Reis, W.L</creator><creator>de Castro, M</creator><creator>Elias, L.L.K</creator><creator>Antunes-Rodrigues, J</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070615</creationdate><title>Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation</title><author>Lauand, F ; Ruginsk, S.G ; Rodrigues, H.L.P ; Reis, W.L ; de Castro, M ; Elias, L.L.K ; Antunes-Rodrigues, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-3fa684005af24da2167c90892075f73bad1b7df1ebfc6599bc99a0da1879de5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adaptation, Physiological</topic><topic>ANG-II</topic><topic>Angiotensin II - physiology</topic><topic>Animals</topic><topic>ANP</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Atrial Natriuretic Factor - drug effects</topic><topic>Biological and medical sciences</topic><topic>carbachol</topic><topic>Carbachol - pharmacology</topic><topic>Cholinergic Agonists - pharmacology</topic><topic>Corticosterone - blood</topic><topic>Dexamethasone - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glucocorticoids</topic><topic>Glucocorticoids - pharmacology</topic><topic>hypothalamus</topic><topic>Hypothalamus - cytology</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - physiology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>neurohypophysial hormones</topic><topic>Neurology</topic><topic>Oxytocin - blood</topic><topic>Oxytocin - drug effects</topic><topic>Proto-Oncogene Proteins c-fos - drug effects</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stimulation, Chemical</topic><topic>Vasopressins - blood</topic><topic>Vasopressins - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Water-Electrolyte Balance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lauand, F</creatorcontrib><creatorcontrib>Ruginsk, S.G</creatorcontrib><creatorcontrib>Rodrigues, H.L.P</creatorcontrib><creatorcontrib>Reis, W.L</creatorcontrib><creatorcontrib>de Castro, M</creatorcontrib><creatorcontrib>Elias, L.L.K</creatorcontrib><creatorcontrib>Antunes-Rodrigues, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lauand, F</au><au>Ruginsk, S.G</au><au>Rodrigues, H.L.P</au><au>Reis, W.L</au><au>de Castro, M</au><au>Elias, L.L.K</au><au>Antunes-Rodrigues, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2007-06-15</date><risdate>2007</risdate><volume>147</volume><issue>1</issue><spage>247</spage><epage>257</epage><pages>247-257</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract The regulation of fluid and electrolyte homeostasis involves the participation of several neuropeptides and hormones that utilize hypothalamic cholinergic, alpha-adrenergic and angiotensinergic neurotransmitters and pathways. Additionally, it has been suggested that hypothalamus–pituitary–adrenal axis activity modulates hormonal responses to blood volume expansion. In the present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0.30 M NaCl, angiotensin-II (ANG-II) and carbachol. We also evaluated the Fos protein immunoreactivity in the median preoptic (MnPO), paraventricular (PVN) and supraoptic (SON) nuclei. Male Wistar rats received an i.p. injection of dexamethasone (1 mg/kg) or vehicle (0.15 M NaCl) 2 h before the i.c.v. microinjections. Blood samples for plasma ANP, OT, AVP and corticosterone determinations were collected at 5 and 20 min after stimulus. Another set of rats was perfused 120 min after stimulation. A significant increase in plasma ANP, OT, AVP and corticosterone levels was observed at 5 and 20 min after each central stimulation compared with isotonic saline–injected group. Pre-treatment with dexamethasone decreased plasma corticosterone and OT levels, with no changes in the AVP secretion. On the other hand, dexamethasone induced a significant increase in plasma ANP levels. A significant increase in the number of Fos immunoreactive neurons was observed in the MnPO, PVN and SON after i.c.v. stimulations. Pre-treatment with dexamethasone induced a significant decrease in Fos immunoreactivity in these nuclei compared with the vehicle. These results indicate that central osmotic, cholinergic, and angiotensinergic stimuli activate MnPO, PVN and SON, with a subsequent OT, AVP, and ANP release. The present data also suggest that these responses are modulated by glucocorticoids.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17524563</pmid><doi>10.1016/j.neuroscience.2007.04.021</doi><tpages>11</tpages></addata></record> |
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| subjects | Adaptation, Physiological ANG-II Angiotensin II - physiology Animals ANP Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - drug effects Biological and medical sciences carbachol Carbachol - pharmacology Cholinergic Agonists - pharmacology Corticosterone - blood Dexamethasone - pharmacology Fundamental and applied biological sciences. Psychology glucocorticoids Glucocorticoids - pharmacology hypothalamus Hypothalamus - cytology Hypothalamus - drug effects Hypothalamus - physiology Injections, Intraventricular Male neurohypophysial hormones Neurology Oxytocin - blood Oxytocin - drug effects Proto-Oncogene Proteins c-fos - drug effects Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Stimulation, Chemical Vasopressins - blood Vasopressins - drug effects Vertebrates: nervous system and sense organs Water-Electrolyte Balance - physiology |
| title | Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation |
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