Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases

Hyperoxic exposure in vivo (> 95% oxygen) attenuates ischemia-reperfusion injury, but the signaling mechanisms of this cardioprotection are not fully determined. We studied a possible role of nitric oxide (NO) and mitogen activated protein kinases (MAPK) in hyperoxic protection. Mice (n = 7-9 in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Basic research in cardiology 2007-07, Vol.102 (4), p.318-326
Hauptverfasser:	Ruusalepp, Arno, Czibik, Gabor, Flatebø, Torun, Vaage, Jarle, Valen, Guro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coronary Circulation Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Hyperoxia - enzymology Hyperoxia - metabolism Hyperoxia - pathology Hyperoxia - physiopathology Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Myocardial Infarction - enzymology Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Myocardium - metabolism Myocardium - pathology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pyrazoles - pharmacology Pyridines - pharmacology Signal Transduction - drug effects Ventricular Function, Left Ventricular Pressure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!