Placental ABCA1 Expression is Reduced in Primary Antiphospholipid Syndrome Compared to Pre-eclampsia and Controls

Abstract The ATP binding cassette transporter A1 (ABCA1) mediates cellular cholesterol and phospholipid efflux, and is implicated in phosphatidylserine translocation and apoptosis. Loss of functional ABCA1 in null mice results in severe placental malformation. This study aimed to establish the place...

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Veröffentlicht in:	Placenta (Eastbourne) 2007-07, Vol.28 (7), p.701-708
Hauptverfasser:	Albrecht, C, Soumian, S, Tetlow, N, Patel, P, Sullivan, M.H.F, Lakasing, L, Nicolaides, K, Williamson, C
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 Adolescent Adult Antiphospholipid syndrome Antiphospholipid Syndrome - genetics Antiphospholipid Syndrome - metabolism Apoptosis ATP binding cassette ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - analysis ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Cholesterol Down-Regulation Embryology: invertebrates and vertebrates. Teratology Endothelium, Vascular - chemistry Female Fundamental and applied biological sciences. Psychology Gene Expression Humans Immunohistochemistry In Situ Hybridization, Fluorescence Internal Medicine mRNA expression Obstetrics and Gynecology Placenta Placenta - chemistry Placenta - metabolism Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Preeclampsia Pregnancy Protein expression RNA, Messenger - analysis RNA, Messenger - metabolism Steroidogenesis
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