RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat

Transient receptor potential vanilloid (TRPV)1 is a ligand‐gated cation channel expressed by primary sensory neurons, including those in the dorsal root ganglia (DRG). TRPV1 plays an essential role in development of inflammatory thermal hyperalgesia after tissue injury and its expression in rat lumb...

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Veröffentlicht in:	The European journal of neuroscience 2007-05, Vol.25 (10), p.2956-2963
Hauptverfasser:	Kasama, Susumu, Kawakubo, Masatomo, Suzuki, Takefumi, Nishizawa, Tomoko, Ishida, Akiko, Nakayama, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal dorsal root ganglia Down-Regulation - genetics Forelimb - innervation Forelimb - physiopathology Freund's Adjuvant - adverse effects Ganglia, Spinal - metabolism Ganglia, Spinal - physiopathology Hyperalgesia - genetics Hyperalgesia - metabolism Hyperalgesia - physiopathology immunohistochemistry Inflammation - genetics Inflammation - metabolism Inflammation - physiopathology Inflammation Mediators - adverse effects Male Neurons, Afferent - metabolism Nociceptors - metabolism Nociceptors - physiopathology pain Pain Threshold - physiology PC12 Cells Rats Rats, Sprague-Dawley Reaction Time - genetics RNA Interference RNA, Small Interfering - pharmacology Sensory Receptor Cells - metabolism Sensory Receptor Cells - physiopathology short interfering RNA Skin - innervation Skin - physiopathology TRPV Cation Channels - genetics
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