Impact of Metabolic Syndrome on Atherosclerotic Burden and Cardiovascular Prognosis
Patients with metabolic syndrome (MS) are at increased risk of cardiovascular atherosclerosis. The aim of this study was to evaluate the impact of MS on cardiovascular prognosis in context with atherosclerotic burden. A total of 811 patients with coronary heart disease (CHD) were included and caroti...
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| Veröffentlicht in: | The American journal of cardiology 2007-06, Vol.99 (12), p.1623-1628 |
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| container_title | The American journal of cardiology |
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| creator | Espinola-Klein, Christine, MD Rupprecht, Hans J., MD Bickel, Christoph, MD Post, Felix, MD Genth-Zotz, Sabine, MD Lackner, Karl, MD Munzel, Thomas, MD Blankenberg, Stefan, MD |
| description | Patients with metabolic syndrome (MS) are at increased risk of cardiovascular atherosclerosis. The aim of this study was to evaluate the impact of MS on cardiovascular prognosis in context with atherosclerotic burden. A total of 811 patients with coronary heart disease (CHD) were included and carotid and leg arteries were examined using sonographic methods. Patients with low (CHD only, n = 428, 52.8%) or high atherosclerotic burden (CHD and peripheral atherosclerosis, n = 383, 47.2%) were compared. Patients with ≥3 of the following criteria: triglycerides ≥150 mg/dl, high-density lipoprotein cholesterol |
| doi_str_mv | 10.1016/j.amjcard.2007.01.049 |
| format | Article |
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The aim of this study was to evaluate the impact of MS on cardiovascular prognosis in context with atherosclerotic burden. A total of 811 patients with coronary heart disease (CHD) were included and carotid and leg arteries were examined using sonographic methods. Patients with low (CHD only, n = 428, 52.8%) or high atherosclerotic burden (CHD and peripheral atherosclerosis, n = 383, 47.2%) were compared. Patients with ≥3 of the following criteria: triglycerides ≥150 mg/dl, high-density lipoprotein cholesterol <40 mg/dl (men) and <50 mg/dl (women), body mass index >30 kg/m2 , blood pressure ≥130/85 mm Hg, and fasting glucose ≥100 mg/dl were defined as having MS (n = 349, 43.0%). Follow-up data (median 6.7 years) were available for 807 patients (99.5%), and 175 patients (21.7%) experienced cardiovascular events (myocardial infarction, death, and stroke). The presence of MS significantly increased cardiovascular events in patients with low and high atherosclerotic burden (low: MS yes 21.2%, MS no 12.9%, p = 0.02; high: MS yes 34.3%, MS no 26.5%, p = 0.01). MS could be identified as an independent predictor for cardiovascular events in all patients (hazard ratio 1.7, 95% confidence interval 1.3 to 2.3, p <0.0001, adjusted) and patients with high atherosclerotic burden in particular (hazard ratio 1.8, 95% confidence interval 1.2 to 2.6, p = 0.005, adjusted). In conclusion, MS markedly worsens the long-term prognosis of patients with both low and high atherosclerotic burden. Moreover, patients with high atherosclerotic burden and MS should be considered a high-risk population and treated accordingly.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2007.01.049</identifier><identifier>PMID: 17560864</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - diagnostic imaging ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Carotid Arteries - diagnostic imaging ; Coronary Disease - diagnostic imaging ; Female ; Humans ; Leg - blood supply ; Leg - diagnostic imaging ; Male ; Medical prognosis ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Metabolic Syndrome - diagnostic imaging ; Middle Aged ; Miscellaneous ; Other metabolic disorders ; Prognosis ; Prospective Studies ; Risk factors ; Ultrasonography, Doppler, Duplex ; Veins & arteries</subject><ispartof>The American journal of cardiology, 2007-06, Vol.99 (12), p.1623-1628</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Jun 15, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-3039dc47e510c436b7d23ac130a022c3ae5c80ea6a40e13132a090aa3b61b65e3</citedby><cites>FETCH-LOGICAL-c541t-3039dc47e510c436b7d23ac130a022c3ae5c80ea6a40e13132a090aa3b61b65e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914907004584$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20282406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17560864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Espinola-Klein, Christine, MD</creatorcontrib><creatorcontrib>Rupprecht, Hans J., MD</creatorcontrib><creatorcontrib>Bickel, Christoph, MD</creatorcontrib><creatorcontrib>Post, Felix, MD</creatorcontrib><creatorcontrib>Genth-Zotz, Sabine, MD</creatorcontrib><creatorcontrib>Lackner, Karl, MD</creatorcontrib><creatorcontrib>Munzel, Thomas, MD</creatorcontrib><creatorcontrib>Blankenberg, Stefan, MD</creatorcontrib><creatorcontrib>Athero</creatorcontrib><creatorcontrib>Investigators</creatorcontrib><creatorcontrib>AtheroGene Investigators</creatorcontrib><title>Impact of Metabolic Syndrome on Atherosclerotic Burden and Cardiovascular Prognosis</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Patients with metabolic syndrome (MS) are at increased risk of cardiovascular atherosclerosis. The aim of this study was to evaluate the impact of MS on cardiovascular prognosis in context with atherosclerotic burden. A total of 811 patients with coronary heart disease (CHD) were included and carotid and leg arteries were examined using sonographic methods. Patients with low (CHD only, n = 428, 52.8%) or high atherosclerotic burden (CHD and peripheral atherosclerosis, n = 383, 47.2%) were compared. Patients with ≥3 of the following criteria: triglycerides ≥150 mg/dl, high-density lipoprotein cholesterol <40 mg/dl (men) and <50 mg/dl (women), body mass index >30 kg/m2 , blood pressure ≥130/85 mm Hg, and fasting glucose ≥100 mg/dl were defined as having MS (n = 349, 43.0%). Follow-up data (median 6.7 years) were available for 807 patients (99.5%), and 175 patients (21.7%) experienced cardiovascular events (myocardial infarction, death, and stroke). The presence of MS significantly increased cardiovascular events in patients with low and high atherosclerotic burden (low: MS yes 21.2%, MS no 12.9%, p = 0.02; high: MS yes 34.3%, MS no 26.5%, p = 0.01). MS could be identified as an independent predictor for cardiovascular events in all patients (hazard ratio 1.7, 95% confidence interval 1.3 to 2.3, p <0.0001, adjusted) and patients with high atherosclerotic burden in particular (hazard ratio 1.8, 95% confidence interval 1.2 to 2.6, p = 0.005, adjusted). In conclusion, MS markedly worsens the long-term prognosis of patients with both low and high atherosclerotic burden. Moreover, patients with high atherosclerotic burden and MS should be considered a high-risk population and treated accordingly.</description><subject>Aged</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Leg - blood supply</subject><subject>Leg - diagnostic imaging</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Ultrasonography, Doppler, Duplex</subject><subject>Veins & arteries</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkluL1DAUgIso7rj6E5Qi6FvrOUmati_KOnhZWFEYfQ5pekYztsmYtAvz702ZssK--JIQ8p3bx8my5wglAso3h1KPB6NDXzKAugQsQbQPsg02dVtgi_xhtgEAVrQo2ovsSYyH9ESs5OPsAutKQiPFJttdj0dtptzv8y806c4P1uS7k-uDHyn3Lr-aflHw0QzpnNLf-zn05HLt-nybqlt_q6OZBx3yb8H_dD7a-DR7tNdDpGfrfZn9-Pjh-_ZzcfP10_X26qYwlcCp4MDb3oiaKgQjuOzqnnFtkIMGxgzXVJkGSEstgJAjZxpa0Jp3EjtZEb_MXp_zHoP_M1Oc1GijoWHQjvwcVQ0Sao5NAl_eAw9-Di71pljqQiZbMkHVGTJp3Bhor47BjjqcFIJalKuDWpWrRbkCVEl5inuxJp-7kfp_UavjBLxagWRKD_ugnbHxjmPAGiZgaeDdmaPk7NZSUNFYcoZ6G8hMqvf2v628vZfBDNbZVPQ3nSjeDY0qMgVqt-zHsh5QA4iqEfwvwzy1dQ</recordid><startdate>20070615</startdate><enddate>20070615</enddate><creator>Espinola-Klein, Christine, MD</creator><creator>Rupprecht, Hans J., MD</creator><creator>Bickel, Christoph, MD</creator><creator>Post, Felix, MD</creator><creator>Genth-Zotz, Sabine, MD</creator><creator>Lackner, Karl, MD</creator><creator>Munzel, Thomas, MD</creator><creator>Blankenberg, Stefan, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070615</creationdate><title>Impact of Metabolic Syndrome on Atherosclerotic Burden and Cardiovascular Prognosis</title><author>Espinola-Klein, Christine, MD ; Rupprecht, Hans J., MD ; Bickel, Christoph, MD ; Post, Felix, MD ; Genth-Zotz, Sabine, MD ; Lackner, Karl, MD ; Munzel, Thomas, MD ; Blankenberg, Stefan, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-3039dc47e510c436b7d23ac130a022c3ae5c80ea6a40e13132a090aa3b61b65e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Leg - blood supply</topic><topic>Leg - diagnostic imaging</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - diagnostic imaging</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><topic>Ultrasonography, Doppler, Duplex</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Espinola-Klein, Christine, MD</creatorcontrib><creatorcontrib>Rupprecht, Hans J., MD</creatorcontrib><creatorcontrib>Bickel, Christoph, MD</creatorcontrib><creatorcontrib>Post, Felix, MD</creatorcontrib><creatorcontrib>Genth-Zotz, Sabine, MD</creatorcontrib><creatorcontrib>Lackner, Karl, MD</creatorcontrib><creatorcontrib>Munzel, Thomas, MD</creatorcontrib><creatorcontrib>Blankenberg, Stefan, MD</creatorcontrib><creatorcontrib>Athero</creatorcontrib><creatorcontrib>Investigators</creatorcontrib><creatorcontrib>AtheroGene Investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Espinola-Klein, Christine, MD</au><au>Rupprecht, Hans J., MD</au><au>Bickel, Christoph, MD</au><au>Post, Felix, MD</au><au>Genth-Zotz, Sabine, MD</au><au>Lackner, Karl, MD</au><au>Munzel, Thomas, MD</au><au>Blankenberg, Stefan, MD</au><aucorp>Athero</aucorp><aucorp>Investigators</aucorp><aucorp>AtheroGene Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Metabolic Syndrome on Atherosclerotic Burden and Cardiovascular Prognosis</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2007-06-15</date><risdate>2007</risdate><volume>99</volume><issue>12</issue><spage>1623</spage><epage>1628</epage><pages>1623-1628</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Patients with metabolic syndrome (MS) are at increased risk of cardiovascular atherosclerosis. The aim of this study was to evaluate the impact of MS on cardiovascular prognosis in context with atherosclerotic burden. A total of 811 patients with coronary heart disease (CHD) were included and carotid and leg arteries were examined using sonographic methods. Patients with low (CHD only, n = 428, 52.8%) or high atherosclerotic burden (CHD and peripheral atherosclerosis, n = 383, 47.2%) were compared. Patients with ≥3 of the following criteria: triglycerides ≥150 mg/dl, high-density lipoprotein cholesterol <40 mg/dl (men) and <50 mg/dl (women), body mass index >30 kg/m2 , blood pressure ≥130/85 mm Hg, and fasting glucose ≥100 mg/dl were defined as having MS (n = 349, 43.0%). Follow-up data (median 6.7 years) were available for 807 patients (99.5%), and 175 patients (21.7%) experienced cardiovascular events (myocardial infarction, death, and stroke). The presence of MS significantly increased cardiovascular events in patients with low and high atherosclerotic burden (low: MS yes 21.2%, MS no 12.9%, p = 0.02; high: MS yes 34.3%, MS no 26.5%, p = 0.01). MS could be identified as an independent predictor for cardiovascular events in all patients (hazard ratio 1.7, 95% confidence interval 1.3 to 2.3, p <0.0001, adjusted) and patients with high atherosclerotic burden in particular (hazard ratio 1.8, 95% confidence interval 1.2 to 2.6, p = 0.005, adjusted). In conclusion, MS markedly worsens the long-term prognosis of patients with both low and high atherosclerotic burden. Moreover, patients with high atherosclerotic burden and MS should be considered a high-risk population and treated accordingly.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17560864</pmid><doi>10.1016/j.amjcard.2007.01.049</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Atherosclerosis (general aspects, experimental research) Atherosclerosis - diagnostic imaging Biological and medical sciences Blood and lymphatic vessels Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Carotid Arteries - diagnostic imaging Coronary Disease - diagnostic imaging Female Humans Leg - blood supply Leg - diagnostic imaging Male Medical prognosis Medical sciences Metabolic diseases Metabolic syndrome Metabolic Syndrome - diagnostic imaging Middle Aged Miscellaneous Other metabolic disorders Prognosis Prospective Studies Risk factors Ultrasonography, Doppler, Duplex Veins & arteries |
| title | Impact of Metabolic Syndrome on Atherosclerotic Burden and Cardiovascular Prognosis |
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