Proposal for a new definition of true cardia carcinoma
Background and Objectives It remains controversial whether cardia carcinoma should be categorized and treated as esophageal cancer or gastric cancer. The purpose of this study was to develop a reasonable definition of cardia carcinoma. Methods Patients with Siewert type II carcinomas were divided in...
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| Veröffentlicht in: | Journal of surgical oncology 2007-06, Vol.95 (7), p.561-566 |
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| creator | Ichikura, Takashi Chochi, Kentaro Sugasawa, Hidekazu Mochizuki, Hidetaka |
| description | Background and Objectives
It remains controversial whether cardia carcinoma should be categorized and treated as esophageal cancer or gastric cancer. The purpose of this study was to develop a reasonable definition of cardia carcinoma.
Methods
Patients with Siewert type II carcinomas were divided into two subgroups: 25 patients with a tumor center within 1 cm of the esophagogastric junction (EGJ) (type IIA) and 22 patients with tumor center 1–2 cm aboral of the EGJ (type IIB). Patients with subcardia carcinomas, 40 with invasion to the EGJ (type III) and 110 without (type IIIe−), were used as controls.
Results
The patients with type IIB carcinomas showed no different characteristics from those with type III or type IIIe− carcinomas, except for the stage of the disease. On the other hand, those with type IIA carcinomas were associated with a higher male/female ratio, higher incidences of elevated appearance, differentiated histology, and mediastinal node metastasis, and a significantly lower survival rate as compared with patients with subcardia carcinomas. Multivariate survival analysis revealed that type IIA is a significant prognostic determinant, but that type IIB is not.
Conclusion
Type IIA carcinomas should be treated as true cardia carcinoma; type IIB as subcardia carcinoma. Our results should be confirmed by a prospective study. J. Surg. Oncol. 2007;95:561–566. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jso.20727 |
| format | Article |
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It remains controversial whether cardia carcinoma should be categorized and treated as esophageal cancer or gastric cancer. The purpose of this study was to develop a reasonable definition of cardia carcinoma.
Methods
Patients with Siewert type II carcinomas were divided into two subgroups: 25 patients with a tumor center within 1 cm of the esophagogastric junction (EGJ) (type IIA) and 22 patients with tumor center 1–2 cm aboral of the EGJ (type IIB). Patients with subcardia carcinomas, 40 with invasion to the EGJ (type III) and 110 without (type IIIe−), were used as controls.
Results
The patients with type IIB carcinomas showed no different characteristics from those with type III or type IIIe− carcinomas, except for the stage of the disease. On the other hand, those with type IIA carcinomas were associated with a higher male/female ratio, higher incidences of elevated appearance, differentiated histology, and mediastinal node metastasis, and a significantly lower survival rate as compared with patients with subcardia carcinomas. Multivariate survival analysis revealed that type IIA is a significant prognostic determinant, but that type IIB is not.
Conclusion
Type IIA carcinomas should be treated as true cardia carcinoma; type IIB as subcardia carcinoma. Our results should be confirmed by a prospective study. J. Surg. Oncol. 2007;95:561–566. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.20727</identifier><identifier>PMID: 17192914</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; adenocarcinomas of the esophagogastric junction ; Aged ; Cardia ; Esophageal Neoplasms - pathology ; Esophagogastric Junction ; Female ; Gastrectomy ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Siewert classification ; Stomach Neoplasms - classification ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; subcardia carcinoma ; Survival Rate</subject><ispartof>Journal of surgical oncology, 2007-06, Vol.95 (7), p.561-566</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4277-7f2de495114b39790c46ab3c2c8a5bdff1fe9320cf344c8658c8b41f02f641b3</citedby><cites>FETCH-LOGICAL-c4277-7f2de495114b39790c46ab3c2c8a5bdff1fe9320cf344c8658c8b41f02f641b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.20727$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.20727$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17192914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ichikura, Takashi</creatorcontrib><creatorcontrib>Chochi, Kentaro</creatorcontrib><creatorcontrib>Sugasawa, Hidekazu</creatorcontrib><creatorcontrib>Mochizuki, Hidetaka</creatorcontrib><title>Proposal for a new definition of true cardia carcinoma</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
It remains controversial whether cardia carcinoma should be categorized and treated as esophageal cancer or gastric cancer. The purpose of this study was to develop a reasonable definition of cardia carcinoma.
Methods
Patients with Siewert type II carcinomas were divided into two subgroups: 25 patients with a tumor center within 1 cm of the esophagogastric junction (EGJ) (type IIA) and 22 patients with tumor center 1–2 cm aboral of the EGJ (type IIB). Patients with subcardia carcinomas, 40 with invasion to the EGJ (type III) and 110 without (type IIIe−), were used as controls.
Results
The patients with type IIB carcinomas showed no different characteristics from those with type III or type IIIe− carcinomas, except for the stage of the disease. On the other hand, those with type IIA carcinomas were associated with a higher male/female ratio, higher incidences of elevated appearance, differentiated histology, and mediastinal node metastasis, and a significantly lower survival rate as compared with patients with subcardia carcinomas. Multivariate survival analysis revealed that type IIA is a significant prognostic determinant, but that type IIB is not.
Conclusion
Type IIA carcinomas should be treated as true cardia carcinoma; type IIB as subcardia carcinoma. Our results should be confirmed by a prospective study. J. Surg. Oncol. 2007;95:561–566. © 2006 Wiley‐Liss, Inc.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>adenocarcinomas of the esophagogastric junction</subject><subject>Aged</subject><subject>Cardia</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagogastric Junction</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Siewert classification</subject><subject>Stomach Neoplasms - classification</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>subcardia carcinoma</subject><subject>Survival Rate</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFPwjAYhhujEUQP_gGzk4mHQdt17Xo0qKASMYGExEvTdW1S3FZsWZB_7xDUk6f38D3vmy8PAJcI9hGEeLAMro8hw-wIdBHkNOaQZ8eg295wTBiHHXAWwhJCyDklp6CDGOKYI9IF9NW7lQuyjIzzkYxqvYkKbWxt19bVkTPR2jc6UtIXVu5C2dpV8hycGFkGfXHIHpg_3M-H43gyHT0ObyexIpixmBlcaMJThEie8PYRRajME4VVJtO8MAYZzRMMlUkIURlNM5XlBBmIDSUoT3rgej-78u6j0WEtKhuULktZa9cEwSCFlDDUgjd7UHkXgtdGrLytpN8KBMXOkWgdiW9HLXt1GG3yShd_5EFKCwz2wMaWevv_kniaTX8m433DhrX-_G1I_y4oS1gqFi8jsRijZz55m4m75Asgq36r</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Ichikura, Takashi</creator><creator>Chochi, Kentaro</creator><creator>Sugasawa, Hidekazu</creator><creator>Mochizuki, Hidetaka</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Proposal for a new definition of true cardia carcinoma</title><author>Ichikura, Takashi ; Chochi, Kentaro ; Sugasawa, Hidekazu ; Mochizuki, Hidetaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4277-7f2de495114b39790c46ab3c2c8a5bdff1fe9320cf344c8658c8b41f02f641b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>adenocarcinomas of the esophagogastric junction</topic><topic>Aged</topic><topic>Cardia</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagogastric Junction</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Siewert classification</topic><topic>Stomach Neoplasms - classification</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>subcardia carcinoma</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichikura, Takashi</creatorcontrib><creatorcontrib>Chochi, Kentaro</creatorcontrib><creatorcontrib>Sugasawa, Hidekazu</creatorcontrib><creatorcontrib>Mochizuki, Hidetaka</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichikura, Takashi</au><au>Chochi, Kentaro</au><au>Sugasawa, Hidekazu</au><au>Mochizuki, Hidetaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proposal for a new definition of true cardia carcinoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>95</volume><issue>7</issue><spage>561</spage><epage>566</epage><pages>561-566</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
It remains controversial whether cardia carcinoma should be categorized and treated as esophageal cancer or gastric cancer. The purpose of this study was to develop a reasonable definition of cardia carcinoma.
Methods
Patients with Siewert type II carcinomas were divided into two subgroups: 25 patients with a tumor center within 1 cm of the esophagogastric junction (EGJ) (type IIA) and 22 patients with tumor center 1–2 cm aboral of the EGJ (type IIB). Patients with subcardia carcinomas, 40 with invasion to the EGJ (type III) and 110 without (type IIIe−), were used as controls.
Results
The patients with type IIB carcinomas showed no different characteristics from those with type III or type IIIe− carcinomas, except for the stage of the disease. On the other hand, those with type IIA carcinomas were associated with a higher male/female ratio, higher incidences of elevated appearance, differentiated histology, and mediastinal node metastasis, and a significantly lower survival rate as compared with patients with subcardia carcinomas. Multivariate survival analysis revealed that type IIA is a significant prognostic determinant, but that type IIB is not.
Conclusion
Type IIA carcinomas should be treated as true cardia carcinoma; type IIB as subcardia carcinoma. Our results should be confirmed by a prospective study. J. Surg. Oncol. 2007;95:561–566. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17192914</pmid><doi>10.1002/jso.20727</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery adenocarcinomas of the esophagogastric junction Aged Cardia Esophageal Neoplasms - pathology Esophagogastric Junction Female Gastrectomy Humans Male Middle Aged Multivariate Analysis Prognosis Proportional Hazards Models Prospective Studies Siewert classification Stomach Neoplasms - classification Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery subcardia carcinoma Survival Rate |
| title | Proposal for a new definition of true cardia carcinoma |
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