Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis
The global regulatory gene, afsR2, from Streptomyces lividans was previously reported to highly stimulate two structurally unrelated antibiotics, actinorhodin and undecylprodigiosin, in both S. lividans and its close relative S. coelicolor. Production of eight avermectin components was also improved...
Gespeichert in:
| Veröffentlicht in: | Journal of bioscience and bioengineering 2000-06, Vol.89 (6), p.606-608 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 608 |
|---|---|
| container_issue | 6 |
| container_start_page | 606 |
| container_title | Journal of bioscience and bioengineering |
| container_volume | 89 |
| creator | Lee, Jae-Young Hwang, Yong-Soon Kim, Sang-Soo Kim, Eung-Soo Choi, Cha-Yong |
| description | The global regulatory gene,
afsR2, from
Streptomyces lividans was previously reported to highly stimulate two structurally unrelated antibiotics, actinorhodin and undecylprodigiosin, in both
S. lividans and its close relative
S. coelicolor. Production of eight avermectin components was also improved in
S. avermitilis: the use of wild-type
S. avermitilis and its high-producing mutant, transformed by introduction of multiple copies of
afsR2, increased the total avermectin productions by 2.3-fold and 1.5-fold, respectively. |
| doi_str_mv | 10.1016/S1389-1723(00)80065-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70606062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1389172300800651</els_id><sourcerecordid>18373626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c617t-ad9a98f104105befe3d372e8b29de5416c12eebf45c62ef9c81c9fbcedc3bbbd3</originalsourceid><addsrcrecordid>eNqFkl2L1DAUhoMo7rr6E1ZyIaKw1ZwkTdsrkWX9YkFx9Tqk6ckQaZvZpB0Yf73pTGHxakgg5yTP-eC8IeQS2DtgoN7fgaibAiou3jD2tmZMlQU8IucgZFVIyeHxYq_IGXmW0h_GoGIVPCVnoLjgNVPn5O-Nc2gnGhw1dNOH1vQ04mbuzRTinm5wxCtqXPrJr6iLYaB3U8TtFIa9xUR7v_OdGRMNIzU7jENO5Ue6jaGbs5Vvs_dfxIHyk-99ek6eONMnfLGeF-T3p5tf11-K2--fv15_vC2sgmoqTNeYpnbAJLCyRYeiExXHuuVNh6UEZYEjtk6WVnF0ja3BNq612FnRtm0nLsjrY97c1v2MadKDTxb73owY5qQrppbFT4IcJJcCToNQi0oorjJYHkEbQ0oRnd5GP5i418D0IqM-yKgXjTRj-iCjhhz3ci0wtwN2D1Grbhl4tQImWdO7aEbr0wMnZZ3LZ-zyiDkTtNnEjHz7wfM_yLtpljofju-Y57_zGHWyHsc8Ox-zlLoL_kSn_wAaUcSd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18373626</pqid></control><display><type>article</type><title>Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Lee, Jae-Young ; Hwang, Yong-Soon ; Kim, Sang-Soo ; Kim, Eung-Soo ; Choi, Cha-Yong</creator><creatorcontrib>Lee, Jae-Young ; Hwang, Yong-Soon ; Kim, Sang-Soo ; Kim, Eung-Soo ; Choi, Cha-Yong</creatorcontrib><description>The global regulatory gene,
afsR2, from
Streptomyces lividans was previously reported to highly stimulate two structurally unrelated antibiotics, actinorhodin and undecylprodigiosin, in both
S. lividans and its close relative
S. coelicolor. Production of eight avermectin components was also improved in
S. avermitilis: the use of wild-type
S. avermitilis and its high-producing mutant, transformed by introduction of multiple copies of
afsR2, increased the total avermectin productions by 2.3-fold and 1.5-fold, respectively.</description><identifier>ISSN: 1389-1723</identifier><identifier>EISSN: 1347-4421</identifier><identifier>DOI: 10.1016/S1389-1723(00)80065-1</identifier><identifier>PMID: 16232806</identifier><language>eng</language><publisher>Amsterdarm: Elsevier B.V</publisher><subject>actinorhodin ; afsR2 ; afsR2 gene ; Antibiotics ; avermectin ; AVERMECTINS ; Biological and medical sciences ; Biosynthesis ; Biotechnology ; DNA sequences ; Fundamental and applied biological sciences. Psychology ; GENES ; global regulatory gene ; Health. Pharmaceutical industry ; High performance liquid chromatography ; Industrial applications and implications. Economical aspects ; Metabolites ; Microorganisms ; Production of active biomolecules ; STREPTOMYCES ; Streptomyces avermitilis ; Streptomyces lividans ; undecylprodigiosin</subject><ispartof>Journal of bioscience and bioengineering, 2000-06, Vol.89 (6), p.606-608</ispartof><rights>2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-ad9a98f104105befe3d372e8b29de5416c12eebf45c62ef9c81c9fbcedc3bbbd3</citedby><cites>FETCH-LOGICAL-c617t-ad9a98f104105befe3d372e8b29de5416c12eebf45c62ef9c81c9fbcedc3bbbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1389172300800651$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1448263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16232806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jae-Young</creatorcontrib><creatorcontrib>Hwang, Yong-Soon</creatorcontrib><creatorcontrib>Kim, Sang-Soo</creatorcontrib><creatorcontrib>Kim, Eung-Soo</creatorcontrib><creatorcontrib>Choi, Cha-Yong</creatorcontrib><title>Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis</title><title>Journal of bioscience and bioengineering</title><addtitle>J Biosci Bioeng</addtitle><description>The global regulatory gene,
afsR2, from
Streptomyces lividans was previously reported to highly stimulate two structurally unrelated antibiotics, actinorhodin and undecylprodigiosin, in both
S. lividans and its close relative
S. coelicolor. Production of eight avermectin components was also improved in
S. avermitilis: the use of wild-type
S. avermitilis and its high-producing mutant, transformed by introduction of multiple copies of
afsR2, increased the total avermectin productions by 2.3-fold and 1.5-fold, respectively.</description><subject>actinorhodin</subject><subject>afsR2</subject><subject>afsR2 gene</subject><subject>Antibiotics</subject><subject>avermectin</subject><subject>AVERMECTINS</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>DNA sequences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENES</subject><subject>global regulatory gene</subject><subject>Health. Pharmaceutical industry</subject><subject>High performance liquid chromatography</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Metabolites</subject><subject>Microorganisms</subject><subject>Production of active biomolecules</subject><subject>STREPTOMYCES</subject><subject>Streptomyces avermitilis</subject><subject>Streptomyces lividans</subject><subject>undecylprodigiosin</subject><issn>1389-1723</issn><issn>1347-4421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkl2L1DAUhoMo7rr6E1ZyIaKw1ZwkTdsrkWX9YkFx9Tqk6ckQaZvZpB0Yf73pTGHxakgg5yTP-eC8IeQS2DtgoN7fgaibAiou3jD2tmZMlQU8IucgZFVIyeHxYq_IGXmW0h_GoGIVPCVnoLjgNVPn5O-Nc2gnGhw1dNOH1vQ04mbuzRTinm5wxCtqXPrJr6iLYaB3U8TtFIa9xUR7v_OdGRMNIzU7jENO5Ue6jaGbs5Vvs_dfxIHyk-99ek6eONMnfLGeF-T3p5tf11-K2--fv15_vC2sgmoqTNeYpnbAJLCyRYeiExXHuuVNh6UEZYEjtk6WVnF0ja3BNq612FnRtm0nLsjrY97c1v2MadKDTxb73owY5qQrppbFT4IcJJcCToNQi0oorjJYHkEbQ0oRnd5GP5i418D0IqM-yKgXjTRj-iCjhhz3ci0wtwN2D1Grbhl4tQImWdO7aEbr0wMnZZ3LZ-zyiDkTtNnEjHz7wfM_yLtpljofju-Y57_zGHWyHsc8Ox-zlLoL_kSn_wAaUcSd</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Lee, Jae-Young</creator><creator>Hwang, Yong-Soon</creator><creator>Kim, Sang-Soo</creator><creator>Kim, Eung-Soo</creator><creator>Choi, Cha-Yong</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis</title><author>Lee, Jae-Young ; Hwang, Yong-Soon ; Kim, Sang-Soo ; Kim, Eung-Soo ; Choi, Cha-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-ad9a98f104105befe3d372e8b29de5416c12eebf45c62ef9c81c9fbcedc3bbbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>actinorhodin</topic><topic>afsR2</topic><topic>afsR2 gene</topic><topic>Antibiotics</topic><topic>avermectin</topic><topic>AVERMECTINS</topic><topic>Biological and medical sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>DNA sequences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENES</topic><topic>global regulatory gene</topic><topic>Health. Pharmaceutical industry</topic><topic>High performance liquid chromatography</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Metabolites</topic><topic>Microorganisms</topic><topic>Production of active biomolecules</topic><topic>STREPTOMYCES</topic><topic>Streptomyces avermitilis</topic><topic>Streptomyces lividans</topic><topic>undecylprodigiosin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jae-Young</creatorcontrib><creatorcontrib>Hwang, Yong-Soon</creatorcontrib><creatorcontrib>Kim, Sang-Soo</creatorcontrib><creatorcontrib>Kim, Eung-Soo</creatorcontrib><creatorcontrib>Choi, Cha-Yong</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bioscience and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jae-Young</au><au>Hwang, Yong-Soon</au><au>Kim, Sang-Soo</au><au>Kim, Eung-Soo</au><au>Choi, Cha-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis</atitle><jtitle>Journal of bioscience and bioengineering</jtitle><addtitle>J Biosci Bioeng</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>89</volume><issue>6</issue><spage>606</spage><epage>608</epage><pages>606-608</pages><issn>1389-1723</issn><eissn>1347-4421</eissn><abstract>The global regulatory gene,
afsR2, from
Streptomyces lividans was previously reported to highly stimulate two structurally unrelated antibiotics, actinorhodin and undecylprodigiosin, in both
S. lividans and its close relative
S. coelicolor. Production of eight avermectin components was also improved in
S. avermitilis: the use of wild-type
S. avermitilis and its high-producing mutant, transformed by introduction of multiple copies of
afsR2, increased the total avermectin productions by 2.3-fold and 1.5-fold, respectively.</abstract><cop>Amsterdarm</cop><pub>Elsevier B.V</pub><pmid>16232806</pmid><doi>10.1016/S1389-1723(00)80065-1</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1389-1723 |
| ispartof | Journal of bioscience and bioengineering, 2000-06, Vol.89 (6), p.606-608 |
| issn | 1389-1723 1347-4421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70606062 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | actinorhodin afsR2 afsR2 gene Antibiotics avermectin AVERMECTINS Biological and medical sciences Biosynthesis Biotechnology DNA sequences Fundamental and applied biological sciences. Psychology GENES global regulatory gene Health. Pharmaceutical industry High performance liquid chromatography Industrial applications and implications. Economical aspects Metabolites Microorganisms Production of active biomolecules STREPTOMYCES Streptomyces avermitilis Streptomyces lividans undecylprodigiosin |
| title | Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A04%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20a%20global%20regulatory%20gene,%20afsR2,%20from%20Streptomyces%20lividans%20on%20avermectin%20production%20in%20Streptomyces%20avermitilis&rft.jtitle=Journal%20of%20bioscience%20and%20bioengineering&rft.au=Lee,%20Jae-Young&rft.date=2000-06-01&rft.volume=89&rft.issue=6&rft.spage=606&rft.epage=608&rft.pages=606-608&rft.issn=1389-1723&rft.eissn=1347-4421&rft_id=info:doi/10.1016/S1389-1723(00)80065-1&rft_dat=%3Cproquest_cross%3E18373626%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18373626&rft_id=info:pmid/16232806&rft_els_id=S1389172300800651&rfr_iscdi=true |