Potential Applications for Circulating Tumor Cells Expressing the Insulin-Like Growth Factor-I Receptor

Purpose: To detect insulin-like growth factor-IR (IGF-IR) on circulating tumor cells (CTC) as a biomarker in the clinical development of a monoclonal human antibody, CP-751,871, targeting IGF-IR. Experimental Design: An automated sample preparation and analysis system for enumerating CTCs (CellTrack...

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Veröffentlicht in:	Clinical cancer research 2007-06, Vol.13 (12), p.3611-3616
Hauptverfasser:	DE BONO, Johann S, ATTARD, Gerhardt, CONNELY, Mark, TERSTAPPEN, Leon W. M. M, GUALBERTO, Antonio, ADJEI, Alex, POLLAK, Michael N, FONG, Peter C, HALUSKA, Paul, ROBERTS, Luisa, MELVIN, Carrie, REPOLLET, Madeline, CHIANESE, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Biomarkers and intervention studies Breast cancer Circulating tumor cells Fluorescent Antibody Technique Genitourinary cancers: prostate Growth factors and receptors Humans IGF-IR Immunologic Techniques Medical sciences Neoplasms - drug therapy Neoplasms - metabolism Neoplastic Cells, Circulating - metabolism Pharmacology. Drug treatments Prostate Receptor, IGF Type 1 - metabolism Treatment Outcome
Online-Zugang:	Volltext
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