Enzymatic Copolymerization to Hybrid Glycosaminoglycans: A Novel Strategy for Intramolecular Hybridization of Polysaccharides

Hybrid glycosaminoglycans (GAGs) having an intramolecularly hybridized structure of hyaluronan−chondroitin (3a) and hyaluronan−chondroitin 4-sulfate (3b) have been synthesized via enzymatic copolymerization catalyzed by hyaluronidase (HAase). N-Acetylhyalobiuronate (GlcAβ(1→3)GlcNAc)-derived oxazoli...

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Veröffentlicht in:	Biomacromolecules 2007-06, Vol.8 (6), p.1802-1806
Hauptverfasser:	Ochiai, Hirofumi, Fujikawa, Shun-Ichi, Ohmae, Masashi, Kobayashi, Shiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Carbohydrate Conformation Chemistry - methods Chondroitin - chemistry Chondroitin Sulfates - chemistry Disaccharides - chemistry Exact sciences and technology Glycosaminoglycans - chemistry Hyaluronic Acid - chemistry Magnetic Resonance Spectroscopy Models, Chemical Molecular Conformation Oxazoles - chemistry Physicochemistry of polymers Polymers - chemistry Polysaccharides Polysaccharides - chemistry Synthetic biopolymers Time Factors
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