Noninflammatory chronic pelvic pain syndrome : Immunological study in blood, ejaculate and prostate tissue
The aim of this prospective study was to observe immunophenotypic patterns in patients with noninflammatory chronic pelvic pain syndrome (Cat IIIB CPPS) for further description and as possible surrogate markers for diagnosis and treatment. Eighty-eight patients with a referral diagnosis of chronic p...
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| Veröffentlicht in: | European urology 2001, Vol.39 (1), p.72-78 |
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| creator | JOHN, Hubert BARGHORN, André FUNKE, Guido SULSER, Tullio HAILEMARIAM, Seife HAURI, Dieter JOLLER-JEMELKA, Helen I |
| description | The aim of this prospective study was to observe immunophenotypic patterns in patients with noninflammatory chronic pelvic pain syndrome (Cat IIIB CPPS) for further description and as possible surrogate markers for diagnosis and treatment.
Eighty-eight patients with a referral diagnosis of chronic prostatitis underwent fractionated urinary cultures including expressed prostate secretion (EPS) and ejaculate analysis twice on two occasions. Monthly serum analyses included C3c, C4, IL-1alpha, sIL-2R, and IL-6. One hundred samples from healthy individuals were used as the control group for serum analysis. Monthly ejaculate testing was done for IgG, IgA, IgM, IL-1alpha, sIL-2R, and IL-6. The control group for ejaculate analysis was composed of 96 normal ejaculates (according to the WHO criteria). Immunohistochemical detection of CD3 cells (T lymphocytes) and CD20 cells (B lymphocytes) was performed in 71 biopsy cylinders of Cat IIIB CPPS patients and in 25 prostate biopsy cylinders of men without symptoms or obstruction.
Complete sampling of urinary, serum and ejaculate specimens was achieved in 50/88 (57%) patients. Cat IIIB CPPS was observed in 44/50 (88%) patients. Intra-acinar T-lymphocytic infiltrates were dominated by T cytotoxic cells (p = 0.05). Immunohistochemical studies showed inflammatory expression in serum complement, serum interleukin, and ejaculate interleukin concentrations in relation to the presence of large numbers of T cells (all p values < or =0.01). No difference was found in the proportion of B lymphocytes in patients with Cat IIIB CPPS compared to the control group. Serum and ejaculate IL-6 and ejaculate IgA increased significantly and dropped again, correlating with a release of clinical symptoms.
Interleukin, complement and immunoglobulin determinations in serum and ejaculate reveal an inflammatory process even in Cat IIIB CPPS. The findings of intra-acinar T-cell-rich infiltrates and the associated inflammatory reaction may be a significant advance in defining Cat IIIB CPPS caused by a possible autoimmune component. Serum and ejaculate IL-6 and ejaculate IgA are possible surrogate markers for the diagnosis and treatment of Cat IIIB CPPS. |
| doi_str_mv | 10.1159/000052415 |
| format | Article |
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Eighty-eight patients with a referral diagnosis of chronic prostatitis underwent fractionated urinary cultures including expressed prostate secretion (EPS) and ejaculate analysis twice on two occasions. Monthly serum analyses included C3c, C4, IL-1alpha, sIL-2R, and IL-6. One hundred samples from healthy individuals were used as the control group for serum analysis. Monthly ejaculate testing was done for IgG, IgA, IgM, IL-1alpha, sIL-2R, and IL-6. The control group for ejaculate analysis was composed of 96 normal ejaculates (according to the WHO criteria). Immunohistochemical detection of CD3 cells (T lymphocytes) and CD20 cells (B lymphocytes) was performed in 71 biopsy cylinders of Cat IIIB CPPS patients and in 25 prostate biopsy cylinders of men without symptoms or obstruction.
Complete sampling of urinary, serum and ejaculate specimens was achieved in 50/88 (57%) patients. Cat IIIB CPPS was observed in 44/50 (88%) patients. Intra-acinar T-lymphocytic infiltrates were dominated by T cytotoxic cells (p = 0.05). Immunohistochemical studies showed inflammatory expression in serum complement, serum interleukin, and ejaculate interleukin concentrations in relation to the presence of large numbers of T cells (all p values < or =0.01). No difference was found in the proportion of B lymphocytes in patients with Cat IIIB CPPS compared to the control group. Serum and ejaculate IL-6 and ejaculate IgA increased significantly and dropped again, correlating with a release of clinical symptoms.
Interleukin, complement and immunoglobulin determinations in serum and ejaculate reveal an inflammatory process even in Cat IIIB CPPS. The findings of intra-acinar T-cell-rich infiltrates and the associated inflammatory reaction may be a significant advance in defining Cat IIIB CPPS caused by a possible autoimmune component. Serum and ejaculate IL-6 and ejaculate IgA are possible surrogate markers for the diagnosis and treatment of Cat IIIB CPPS.</description><identifier>ISSN: 0302-2838</identifier><identifier>EISSN: 1873-7560</identifier><identifier>DOI: 10.1159/000052415</identifier><identifier>PMID: 11173942</identifier><identifier>CODEN: EUURAV</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Adult ; Biological and medical sciences ; Body Fluids - chemistry ; Body Fluids - immunology ; Chronic Disease ; Ejaculation ; Humans ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Pelvic Pain - blood ; Pelvic Pain - etiology ; Pelvic Pain - immunology ; Prospective Studies ; Prostate - immunology ; Prostate - pathology ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>European urology, 2001, Vol.39 (1), p.72-78</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=869342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11173942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JOHN, Hubert</creatorcontrib><creatorcontrib>BARGHORN, André</creatorcontrib><creatorcontrib>FUNKE, Guido</creatorcontrib><creatorcontrib>SULSER, Tullio</creatorcontrib><creatorcontrib>HAILEMARIAM, Seife</creatorcontrib><creatorcontrib>HAURI, Dieter</creatorcontrib><creatorcontrib>JOLLER-JEMELKA, Helen I</creatorcontrib><title>Noninflammatory chronic pelvic pain syndrome : Immunological study in blood, ejaculate and prostate tissue</title><title>European urology</title><addtitle>Eur Urol</addtitle><description>The aim of this prospective study was to observe immunophenotypic patterns in patients with noninflammatory chronic pelvic pain syndrome (Cat IIIB CPPS) for further description and as possible surrogate markers for diagnosis and treatment.
Eighty-eight patients with a referral diagnosis of chronic prostatitis underwent fractionated urinary cultures including expressed prostate secretion (EPS) and ejaculate analysis twice on two occasions. Monthly serum analyses included C3c, C4, IL-1alpha, sIL-2R, and IL-6. One hundred samples from healthy individuals were used as the control group for serum analysis. Monthly ejaculate testing was done for IgG, IgA, IgM, IL-1alpha, sIL-2R, and IL-6. The control group for ejaculate analysis was composed of 96 normal ejaculates (according to the WHO criteria). Immunohistochemical detection of CD3 cells (T lymphocytes) and CD20 cells (B lymphocytes) was performed in 71 biopsy cylinders of Cat IIIB CPPS patients and in 25 prostate biopsy cylinders of men without symptoms or obstruction.
Complete sampling of urinary, serum and ejaculate specimens was achieved in 50/88 (57%) patients. Cat IIIB CPPS was observed in 44/50 (88%) patients. Intra-acinar T-lymphocytic infiltrates were dominated by T cytotoxic cells (p = 0.05). Immunohistochemical studies showed inflammatory expression in serum complement, serum interleukin, and ejaculate interleukin concentrations in relation to the presence of large numbers of T cells (all p values < or =0.01). No difference was found in the proportion of B lymphocytes in patients with Cat IIIB CPPS compared to the control group. Serum and ejaculate IL-6 and ejaculate IgA increased significantly and dropped again, correlating with a release of clinical symptoms.
Interleukin, complement and immunoglobulin determinations in serum and ejaculate reveal an inflammatory process even in Cat IIIB CPPS. The findings of intra-acinar T-cell-rich infiltrates and the associated inflammatory reaction may be a significant advance in defining Cat IIIB CPPS caused by a possible autoimmune component. Serum and ejaculate IL-6 and ejaculate IgA are possible surrogate markers for the diagnosis and treatment of Cat IIIB CPPS.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Fluids - chemistry</subject><subject>Body Fluids - immunology</subject><subject>Chronic Disease</subject><subject>Ejaculation</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Pelvic Pain - blood</subject><subject>Pelvic Pain - etiology</subject><subject>Pelvic Pain - immunology</subject><subject>Prospective Studies</subject><subject>Prostate - immunology</subject><subject>Prostate - pathology</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0302-2838</issn><issn>1873-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90EtLxDAQAOAgiruuHvwDEhA8Wc1j0ybeZPGxsOhFz2Waptolj9q0Qv-9WVydyzDDxwwzCJ1TckOpULckhWBLKg7QnMqCZ4XIySGaE05YxiSXM3QS4zYpLhQ_RjNKacHVks3R9iX41jcWnIMh9BPWn33qaNwZ-71L0HocJ1_3wRl8h9fOjT7Y8NFqsDgOYz3hJCobQn2NzRb0aGEwGHyNuz7EYVcMbYyjOUVHDdhozvZ5gd4fH95Wz9nm9Wm9ut9kHeNiyMSyAKkqzTljhoJueKMaKIRSNQXGiCREiXSTKiSviNRSNg0QwgQIASyXfIGufuem_V-jiUPp2qiNteBNGGNZkDw9gu_gxR6OlTN12fWtg34q_76TwOUeQEznNj143cZ_J3PFk_oBB5tyYg</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>JOHN, Hubert</creator><creator>BARGHORN, André</creator><creator>FUNKE, Guido</creator><creator>SULSER, Tullio</creator><creator>HAILEMARIAM, Seife</creator><creator>HAURI, Dieter</creator><creator>JOLLER-JEMELKA, Helen I</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Noninflammatory chronic pelvic pain syndrome : Immunological study in blood, ejaculate and prostate tissue</title><author>JOHN, Hubert ; BARGHORN, André ; FUNKE, Guido ; SULSER, Tullio ; HAILEMARIAM, Seife ; HAURI, Dieter ; JOLLER-JEMELKA, Helen I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-547a89bc3322e1acf3f9fa7599d1a220800958389783b08c88ffa0025a55a2683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Fluids - chemistry</topic><topic>Body Fluids - immunology</topic><topic>Chronic Disease</topic><topic>Ejaculation</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Pelvic Pain - blood</topic><topic>Pelvic Pain - etiology</topic><topic>Pelvic Pain - immunology</topic><topic>Prospective Studies</topic><topic>Prostate - immunology</topic><topic>Prostate - pathology</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JOHN, Hubert</creatorcontrib><creatorcontrib>BARGHORN, André</creatorcontrib><creatorcontrib>FUNKE, Guido</creatorcontrib><creatorcontrib>SULSER, Tullio</creatorcontrib><creatorcontrib>HAILEMARIAM, Seife</creatorcontrib><creatorcontrib>HAURI, Dieter</creatorcontrib><creatorcontrib>JOLLER-JEMELKA, Helen I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JOHN, Hubert</au><au>BARGHORN, André</au><au>FUNKE, Guido</au><au>SULSER, Tullio</au><au>HAILEMARIAM, Seife</au><au>HAURI, Dieter</au><au>JOLLER-JEMELKA, Helen I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninflammatory chronic pelvic pain syndrome : Immunological study in blood, ejaculate and prostate tissue</atitle><jtitle>European urology</jtitle><addtitle>Eur Urol</addtitle><date>2001</date><risdate>2001</risdate><volume>39</volume><issue>1</issue><spage>72</spage><epage>78</epage><pages>72-78</pages><issn>0302-2838</issn><eissn>1873-7560</eissn><coden>EUURAV</coden><abstract>The aim of this prospective study was to observe immunophenotypic patterns in patients with noninflammatory chronic pelvic pain syndrome (Cat IIIB CPPS) for further description and as possible surrogate markers for diagnosis and treatment.
Eighty-eight patients with a referral diagnosis of chronic prostatitis underwent fractionated urinary cultures including expressed prostate secretion (EPS) and ejaculate analysis twice on two occasions. Monthly serum analyses included C3c, C4, IL-1alpha, sIL-2R, and IL-6. One hundred samples from healthy individuals were used as the control group for serum analysis. Monthly ejaculate testing was done for IgG, IgA, IgM, IL-1alpha, sIL-2R, and IL-6. The control group for ejaculate analysis was composed of 96 normal ejaculates (according to the WHO criteria). Immunohistochemical detection of CD3 cells (T lymphocytes) and CD20 cells (B lymphocytes) was performed in 71 biopsy cylinders of Cat IIIB CPPS patients and in 25 prostate biopsy cylinders of men without symptoms or obstruction.
Complete sampling of urinary, serum and ejaculate specimens was achieved in 50/88 (57%) patients. Cat IIIB CPPS was observed in 44/50 (88%) patients. Intra-acinar T-lymphocytic infiltrates were dominated by T cytotoxic cells (p = 0.05). Immunohistochemical studies showed inflammatory expression in serum complement, serum interleukin, and ejaculate interleukin concentrations in relation to the presence of large numbers of T cells (all p values < or =0.01). No difference was found in the proportion of B lymphocytes in patients with Cat IIIB CPPS compared to the control group. Serum and ejaculate IL-6 and ejaculate IgA increased significantly and dropped again, correlating with a release of clinical symptoms.
Interleukin, complement and immunoglobulin determinations in serum and ejaculate reveal an inflammatory process even in Cat IIIB CPPS. The findings of intra-acinar T-cell-rich infiltrates and the associated inflammatory reaction may be a significant advance in defining Cat IIIB CPPS caused by a possible autoimmune component. Serum and ejaculate IL-6 and ejaculate IgA are possible surrogate markers for the diagnosis and treatment of Cat IIIB CPPS.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>11173942</pmid><doi>10.1159/000052415</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Body Fluids - chemistry Body Fluids - immunology Chronic Disease Ejaculation Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Pelvic Pain - blood Pelvic Pain - etiology Pelvic Pain - immunology Prospective Studies Prostate - immunology Prostate - pathology Tumors of the urinary system Urinary tract. Prostate gland |
| title | Noninflammatory chronic pelvic pain syndrome : Immunological study in blood, ejaculate and prostate tissue |
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