Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer
Abstract We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate whether these markers could predict lymph node metastasis in human breast cancer. Higher rates of CXCR4 (61%), VEGF (68%), and MMP-...
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| Veröffentlicht in: | Cancer letters 2007-08, Vol.253 (1), p.34-42 |
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| container_title | Cancer letters |
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| creator | Hao, Li Zhang, Chunhui Qiu, Yuhua Wang, Liang Luo, Yunbao Jin, Min Zhang, Yi Guo, Taylor B Matsushima, Kouji Zhang, Yanyun |
| description | Abstract We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate whether these markers could predict lymph node metastasis in human breast cancer. Higher rates of CXCR4 (61%), VEGF (68%), and MMP-9 (63%) expression were found in breast cancer tissues than in normal and atypical hyperplasia tissues. The expression of these markers was significantly associated with primary tumor progression, histological grade, and lymph node status. We found there were significant correlations between the expressions of any two of the three markers ( P < 0.001). Furthermore, our studies indicated that concomitant expression of CXCR4/VEGF ( P = 0.007), CXCR4/MMP-9 ( P < 0.001) or VEGF/MMP-9 ( P = 0.003) had stronger correlation with lymph node metastasis than did each alone and that combined expression of all three makers strongly correlated with lymph node metastasis ( P < 0.001). Thus, simultaneously examining the expression of CXCR4, VEGF, and MMP-9 in cancer tissues of breast cancer will provide valuable prognostic diagnosis of lymph node metastasis. |
| doi_str_mv | 10.1016/j.canlet.2007.01.005 |
| format | Article |
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Higher rates of CXCR4 (61%), VEGF (68%), and MMP-9 (63%) expression were found in breast cancer tissues than in normal and atypical hyperplasia tissues. The expression of these markers was significantly associated with primary tumor progression, histological grade, and lymph node status. We found there were significant correlations between the expressions of any two of the three markers ( P < 0.001). Furthermore, our studies indicated that concomitant expression of CXCR4/VEGF ( P = 0.007), CXCR4/MMP-9 ( P < 0.001) or VEGF/MMP-9 ( P = 0.003) had stronger correlation with lymph node metastasis than did each alone and that combined expression of all three makers strongly correlated with lymph node metastasis ( P < 0.001). Thus, simultaneously examining the expression of CXCR4, VEGF, and MMP-9 in cancer tissues of breast cancer will provide valuable prognostic diagnosis of lymph node metastasis.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2007.01.005</identifier><identifier>PMID: 17306924</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Angiogenesis ; Biomarkers, Tumor - analysis ; Breast cancer ; Breast Neoplasms - metabolism ; Chemokines ; Cloning ; Correlation analysis ; CXCR4 ; Cytokines ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Matrix Metalloproteinase 9 - metabolism ; MMP-9 ; Mortality ; Receptors, CXCR4 - metabolism ; Rodents ; Surgery ; Tumors ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - analysis ; Vascular Endothelial Growth Factor A - metabolism ; VEGF</subject><ispartof>Cancer letters, 2007-08, Vol.253 (1), p.34-42</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Aug 8, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-d3debf3cce457ed880a0203775fd1bf18b375fafc08983531e47980dfd24ebea3</citedby><cites>FETCH-LOGICAL-c540t-d3debf3cce457ed880a0203775fd1bf18b375fafc08983531e47980dfd24ebea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2007.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17306924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Li</creatorcontrib><creatorcontrib>Zhang, Chunhui</creatorcontrib><creatorcontrib>Qiu, Yuhua</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Luo, Yunbao</creatorcontrib><creatorcontrib>Jin, Min</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Guo, Taylor B</creatorcontrib><creatorcontrib>Matsushima, Kouji</creatorcontrib><creatorcontrib>Zhang, Yanyun</creatorcontrib><title>Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate whether these markers could predict lymph node metastasis in human breast cancer. Higher rates of CXCR4 (61%), VEGF (68%), and MMP-9 (63%) expression were found in breast cancer tissues than in normal and atypical hyperplasia tissues. The expression of these markers was significantly associated with primary tumor progression, histological grade, and lymph node status. We found there were significant correlations between the expressions of any two of the three markers ( P < 0.001). Furthermore, our studies indicated that concomitant expression of CXCR4/VEGF ( P = 0.007), CXCR4/MMP-9 ( P < 0.001) or VEGF/MMP-9 ( P = 0.003) had stronger correlation with lymph node metastasis than did each alone and that combined expression of all three makers strongly correlated with lymph node metastasis ( P < 0.001). Thus, simultaneously examining the expression of CXCR4, VEGF, and MMP-9 in cancer tissues of breast cancer will provide valuable prognostic diagnosis of lymph node metastasis.</description><subject>Angiogenesis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Chemokines</subject><subject>Cloning</subject><subject>Correlation analysis</subject><subject>CXCR4</subject><subject>Cytokines</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>MMP-9</subject><subject>Mortality</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Rodents</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - analysis</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>VEGF</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoMo7rj6D0QCglfbetIkk_ZGkGG_YBdl_cC7kCanbsY2HZNWmH9vygws7M1CICF5zjl5z3sIecugZMDWH7elNaHHqawAVAmsBJDPyIrVqipUU8NzsgIOouA1lyfkVUpbyIRQ8iU5YYrDuqnEiug7tOPQ-mAmPwY6dnTza3MnzujP88uLM2qCo7e3X4uG7iI6bycfftN-P-zuaRgd0gEnk_LyifpA7-fBBNpGzHc0_85ifE1edKZP-Oa4n5IfF-ffN1fFzZfL683nm8JKAVPhuMO249aikApdXYOBCrhSsnOs7Vjd8nw0nYW6yXo4Q7FodJ2rBLZo-Cn5cMi7i-PfGdOkB58s9r0JOM5JK5BNIxt4EmRNoxiTC_j-Ebgd5xiyCJ2fpagrxdaZEgfKxjGliJ3eRT-YuNcM9OKT3uqDT3rxSQPT2YUc9u6YfG4HdA9BR2My8OkAYG7aP49RJ-sxd9T5iHbSbvRPVXicwPY-eGv6P7jH9KBFp0qD_rbMyjIqoPKYsKri_wFUDbhc</recordid><startdate>20070808</startdate><enddate>20070808</enddate><creator>Hao, Li</creator><creator>Zhang, Chunhui</creator><creator>Qiu, Yuhua</creator><creator>Wang, Liang</creator><creator>Luo, Yunbao</creator><creator>Jin, Min</creator><creator>Zhang, Yi</creator><creator>Guo, Taylor B</creator><creator>Matsushima, Kouji</creator><creator>Zhang, Yanyun</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20070808</creationdate><title>Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer</title><author>Hao, Li ; Zhang, Chunhui ; Qiu, Yuhua ; Wang, Liang ; Luo, Yunbao ; Jin, Min ; Zhang, Yi ; Guo, Taylor B ; Matsushima, Kouji ; Zhang, Yanyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-d3debf3cce457ed880a0203775fd1bf18b375fafc08983531e47980dfd24ebea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Angiogenesis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Chemokines</topic><topic>Cloning</topic><topic>Correlation analysis</topic><topic>CXCR4</topic><topic>Cytokines</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>MMP-9</topic><topic>Mortality</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Rodents</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - analysis</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Li</creatorcontrib><creatorcontrib>Zhang, Chunhui</creatorcontrib><creatorcontrib>Qiu, Yuhua</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Luo, Yunbao</creatorcontrib><creatorcontrib>Jin, Min</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Guo, Taylor B</creatorcontrib><creatorcontrib>Matsushima, Kouji</creatorcontrib><creatorcontrib>Zhang, Yanyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Li</au><au>Zhang, Chunhui</au><au>Qiu, Yuhua</au><au>Wang, Liang</au><au>Luo, Yunbao</au><au>Jin, Min</au><au>Zhang, Yi</au><au>Guo, Taylor B</au><au>Matsushima, Kouji</au><au>Zhang, Yanyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2007-08-08</date><risdate>2007</risdate><volume>253</volume><issue>1</issue><spage>34</spage><epage>42</epage><pages>34-42</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate whether these markers could predict lymph node metastasis in human breast cancer. Higher rates of CXCR4 (61%), VEGF (68%), and MMP-9 (63%) expression were found in breast cancer tissues than in normal and atypical hyperplasia tissues. The expression of these markers was significantly associated with primary tumor progression, histological grade, and lymph node status. We found there were significant correlations between the expressions of any two of the three markers ( P < 0.001). Furthermore, our studies indicated that concomitant expression of CXCR4/VEGF ( P = 0.007), CXCR4/MMP-9 ( P < 0.001) or VEGF/MMP-9 ( P = 0.003) had stronger correlation with lymph node metastasis than did each alone and that combined expression of all three makers strongly correlated with lymph node metastasis ( P < 0.001). 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| subjects | Angiogenesis Biomarkers, Tumor - analysis Breast cancer Breast Neoplasms - metabolism Chemokines Cloning Correlation analysis CXCR4 Cytokines Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Lymphatic Metastasis Matrix Metalloproteinase 9 - metabolism MMP-9 Mortality Receptors, CXCR4 - metabolism Rodents Surgery Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - metabolism VEGF |
| title | Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer |
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