Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development

The Runt family transcription factor CBFalpha2 (AML1, PEBP2alphaB, or Runx1) is required by hematopoietic stem cells and expressed at high levels in T-lineage cells. In human T cells CBFalpha2 is usually transcribed from a different promoter (distal promoter) than in myeloid cells (proximal promoter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Developmental biology 2001-01, Vol.229 (2), p.363-382
Hauptverfasser:	Telfer, J C, Rothenberg, E V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cell Differentiation Cell Line Chickens Epitopes - chemistry Exons Female Gene Expression Regulation Gene Library Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - immunology Humans Immunohistochemistry Killer Cells, Natural - immunology Male Mice Mice, Inbred C57BL Molecular Sequence Data Neoplasm Proteins Organ Specificity Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Spleen - immunology T-Lymphocytes - immunology Thymus Gland - immunology Transcription Factors - analysis Transcription Factors - genetics Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!