Analysis of gene expression identifies PLAB as a mediator of the apoptotic activity of fenretinide in human ovarian cancer cells

Fenretinide (4-HPR) is a synthetic retinoid with antitumor activity, which induces apoptosis in cancer cell lines of different histotypes. To identify genes contributing to its apoptotic activity in ovarian cancer cells, we monitored, by cDNA arrays, gene expression changes after 4-HPR exposure in A...

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Veröffentlicht in:	Oncogene 2007-06, Vol.26 (27), p.3952-3962
Hauptverfasser:	Appierto, V, Villani, M G, Cavadini, E, Gariboldi, M, De Cecco, L, Pierotti, M A, Lambert, J R, Reid, J, Tiberio, P, Colombo, N, Formelli, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA microarrays EGR-1 protein Female Female genital diseases Fenretinide - pharmacology Fenretinide - therapeutic use Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Growth Differentiation Factor 15 Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Medical sciences Medicine Medicine & Public Health Molecular and cellular biology mRNA stability Oligonucleotide Array Sequence Analysis Oncology original-article Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology p53 Protein Patients Retinoids - chemistry Retinoids - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA-mediated interference siRNA Time Factors Transcription, Genetic - drug effects Tumor cell lines Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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