Immune parameters of immunised cod (Gadus morhua L.)
The immune response of cod (Gadus morhua L.) is unusual in that specific antibody response is limited or absent. In the present study cod was immunised with haptenated and non-haptenated protein antigen at two different temperatures and the antibody response monitored over a period of 18 months. Oth...
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| Veröffentlicht in: | Fish & shellfish immunology 2001-01, Vol.11 (1), p.75-89 |
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| container_title | Fish & shellfish immunology |
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| creator | Magnadóttir, Bergljót Jónsdóttir, Halla Helgason, Sigurđur Björnsson, Björn Solem, Stein Tore Pilström, Lars |
| description | The immune response of cod (Gadus morhua L.) is unusual in that specific antibody response is limited or absent. In the present study cod was immunised with haptenated and non-haptenated protein antigen at two different temperatures and the antibody response monitored over a period of 18 months. Other humoral parameters of immunological importance were also analysed, namely total immunoglobulin concentration, anti-protease and spontaneous haemolytic activity. No specific antibody response was detected but increased activity of non-specific anti-TNP antibodies was observed 10–12 weeks after immunisation, irrespective of the antigen used. This antibody activity was attributed to the adjuvant used (FCA) and did not cross react with other antigens tested. Other parameters were probably not influenced by the immunisation but seasonal fluctuations were indicated. The immunoglobulin level appeared to peak in August–September and the anti-protease activity and the haemolytic activity in October–January. |
| doi_str_mv | 10.1006/fsim.2000.0296 |
| format | Article |
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In the present study cod was immunised with haptenated and non-haptenated protein antigen at two different temperatures and the antibody response monitored over a period of 18 months. Other humoral parameters of immunological importance were also analysed, namely total immunoglobulin concentration, anti-protease and spontaneous haemolytic activity. No specific antibody response was detected but increased activity of non-specific anti-TNP antibodies was observed 10–12 weeks after immunisation, irrespective of the antigen used. This antibody activity was attributed to the adjuvant used (FCA) and did not cross react with other antigens tested. Other parameters were probably not influenced by the immunisation but seasonal fluctuations were indicated. The immunoglobulin level appeared to peak in August–September and the anti-protease activity and the haemolytic activity in October–January.</description><identifier>ISSN: 1050-4648</identifier><identifier>EISSN: 1095-9947</identifier><identifier>DOI: 10.1006/fsim.2000.0296</identifier><identifier>PMID: 11271604</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antibodies - analysis ; Blood Proteins - analysis ; cod, Gadus morhua L., non-specific antibodies, IgM, anti-protease, haemolytic activity ; Endopeptidases - metabolism ; Fishes - immunology ; Gadus morhua ; Hemolysis ; Immunization - veterinary ; Immunoglobulin M - blood ; Marine ; Seasons ; Time Factors</subject><ispartof>Fish & shellfish immunology, 2001-01, Vol.11 (1), p.75-89</ispartof><rights>2001 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-99ebf8eeeaf3dfd18c6dcbf81b225ca8f42325b2cfc9cb06b543c07a4947bcf03</citedby><cites>FETCH-LOGICAL-c371t-99ebf8eeeaf3dfd18c6dcbf81b225ca8f42325b2cfc9cb06b543c07a4947bcf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/fsim.2000.0296$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11271604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magnadóttir, Bergljót</creatorcontrib><creatorcontrib>Jónsdóttir, Halla</creatorcontrib><creatorcontrib>Helgason, Sigurđur</creatorcontrib><creatorcontrib>Björnsson, Björn</creatorcontrib><creatorcontrib>Solem, Stein Tore</creatorcontrib><creatorcontrib>Pilström, Lars</creatorcontrib><title>Immune parameters of immunised cod (Gadus morhua L.)</title><title>Fish & shellfish immunology</title><addtitle>Fish Shellfish Immunol</addtitle><description>The immune response of cod (Gadus morhua L.) is unusual in that specific antibody response is limited or absent. In the present study cod was immunised with haptenated and non-haptenated protein antigen at two different temperatures and the antibody response monitored over a period of 18 months. Other humoral parameters of immunological importance were also analysed, namely total immunoglobulin concentration, anti-protease and spontaneous haemolytic activity. No specific antibody response was detected but increased activity of non-specific anti-TNP antibodies was observed 10–12 weeks after immunisation, irrespective of the antigen used. This antibody activity was attributed to the adjuvant used (FCA) and did not cross react with other antigens tested. Other parameters were probably not influenced by the immunisation but seasonal fluctuations were indicated. The immunoglobulin level appeared to peak in August–September and the anti-protease activity and the haemolytic activity in October–January.</description><subject>Animals</subject><subject>Antibodies - analysis</subject><subject>Blood Proteins - analysis</subject><subject>cod, Gadus morhua L., non-specific antibodies, IgM, anti-protease, haemolytic activity</subject><subject>Endopeptidases - metabolism</subject><subject>Fishes - immunology</subject><subject>Gadus morhua</subject><subject>Hemolysis</subject><subject>Immunization - veterinary</subject><subject>Immunoglobulin M - blood</subject><subject>Marine</subject><subject>Seasons</subject><subject>Time Factors</subject><issn>1050-4648</issn><issn>1095-9947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rp69Sg9iR5a89WkPcrix8KCFz2HNJlgZLNdk1bw35uyC57E0wwvz7wMD0KXBFcEY3Hnkg8VxRhXmLbiCM0Jbuuybbk8nvYal1zwZobOUvrIlGACn6IZIVQSgfkc8VUI4xaKnY46wAAxFb0r_BT6BLYwvS1unrQdUxH6-D7qYl3dnqMTpzcJLg5zgd4eH16Xz-X65Wm1vF-Xhkky5C-gcw0AaMess6QxwpqckI7S2ujGccpo3VHjTGs6LLqaM4Ol5vn7zjjMFuh637uL_ecIaVDBJwObjd5CPyYlcd02TLJ_QSIbSqUUGaz2oIl9ShGc2kUfdPxWBKtJqJqEqkmomoTmg6tD89gFsL_4wWAGmj0AWcSXh6iS8bA1YH0EMyjb-7-6fwB2VIPy</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Magnadóttir, Bergljót</creator><creator>Jónsdóttir, Halla</creator><creator>Helgason, Sigurđur</creator><creator>Björnsson, Björn</creator><creator>Solem, Stein Tore</creator><creator>Pilström, Lars</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TN</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200101</creationdate><title>Immune parameters of immunised cod (Gadus morhua L.)</title><author>Magnadóttir, Bergljót ; Jónsdóttir, Halla ; Helgason, Sigurđur ; Björnsson, Björn ; Solem, Stein Tore ; Pilström, Lars</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-99ebf8eeeaf3dfd18c6dcbf81b225ca8f42325b2cfc9cb06b543c07a4947bcf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antibodies - analysis</topic><topic>Blood Proteins - analysis</topic><topic>cod, Gadus morhua L., non-specific antibodies, IgM, anti-protease, haemolytic activity</topic><topic>Endopeptidases - metabolism</topic><topic>Fishes - immunology</topic><topic>Gadus morhua</topic><topic>Hemolysis</topic><topic>Immunization - veterinary</topic><topic>Immunoglobulin M - blood</topic><topic>Marine</topic><topic>Seasons</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magnadóttir, Bergljót</creatorcontrib><creatorcontrib>Jónsdóttir, Halla</creatorcontrib><creatorcontrib>Helgason, Sigurđur</creatorcontrib><creatorcontrib>Björnsson, Björn</creatorcontrib><creatorcontrib>Solem, Stein Tore</creatorcontrib><creatorcontrib>Pilström, Lars</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Fish & shellfish immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magnadóttir, Bergljót</au><au>Jónsdóttir, Halla</au><au>Helgason, Sigurđur</au><au>Björnsson, Björn</au><au>Solem, Stein Tore</au><au>Pilström, Lars</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune parameters of immunised cod (Gadus morhua L.)</atitle><jtitle>Fish & shellfish immunology</jtitle><addtitle>Fish Shellfish Immunol</addtitle><date>2001-01</date><risdate>2001</risdate><volume>11</volume><issue>1</issue><spage>75</spage><epage>89</epage><pages>75-89</pages><issn>1050-4648</issn><eissn>1095-9947</eissn><abstract>The immune response of cod (Gadus morhua L.) is unusual in that specific antibody response is limited or absent. In the present study cod was immunised with haptenated and non-haptenated protein antigen at two different temperatures and the antibody response monitored over a period of 18 months. Other humoral parameters of immunological importance were also analysed, namely total immunoglobulin concentration, anti-protease and spontaneous haemolytic activity. No specific antibody response was detected but increased activity of non-specific anti-TNP antibodies was observed 10–12 weeks after immunisation, irrespective of the antigen used. This antibody activity was attributed to the adjuvant used (FCA) and did not cross react with other antigens tested. Other parameters were probably not influenced by the immunisation but seasonal fluctuations were indicated. The immunoglobulin level appeared to peak in August–September and the anti-protease activity and the haemolytic activity in October–January.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11271604</pmid><doi>10.1006/fsim.2000.0296</doi><tpages>15</tpages></addata></record> |
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| identifier | ISSN: 1050-4648 |
| ispartof | Fish & shellfish immunology, 2001-01, Vol.11 (1), p.75-89 |
| issn | 1050-4648 1095-9947 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antibodies - analysis Blood Proteins - analysis cod, Gadus morhua L., non-specific antibodies, IgM, anti-protease, haemolytic activity Endopeptidases - metabolism Fishes - immunology Gadus morhua Hemolysis Immunization - veterinary Immunoglobulin M - blood Marine Seasons Time Factors |
| title | Immune parameters of immunised cod (Gadus morhua L.) |
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