MyoD Cannot Compensate for the Absence of Myogenin during Skeletal Muscle Differentiation in Murine Embryonic Stem Cells

myogenin (−/−) mice display severe skeletal muscle defects despite expressing normal levels of MyoD. The failure of MyoD to compensate for myogenin could be explained by distinctions in protein function or by differences in patterns of gene expression. To distinguish between these two possibilities,...

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