Restricted chromosome breakpoint sites on 11q22–q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement
We analyzed 32 patients with various hematological malignancies including acute myelocytic leukemia and non-Hodgkin lymphoma with a breakpoint at 11q22–q25 of chromosome 11, but who did not have rearrangements of the MLL/ALL-1 gene. The breakpoint in each patient was identified by fluorescence in si...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2001, Vol.124 (1), p.27-35 |
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| creator | Tanaka, Kimio Eguchi, Mariko Eguchi-Ishimae, Minenori Hasegawa, Akira Ohgami, Akiko Kikuchi, Masahiro Kyo, Taichi Asaoku, Hideki Dohy, Hiroo Kamada, Nanao |
| description | We analyzed 32 patients with various hematological malignancies including acute myelocytic leukemia and non-Hodgkin lymphoma with a breakpoint at 11q22–q25 of chromosome 11, but who did not have rearrangements of the
MLL/ALL-1 gene. The breakpoint in each patient was identified by fluorescence in situ hybridization using 21 cosmid probes and 2 YAC probes. Breakpoints for each “rearrangement” involving translocations such as t(1;11), t(2;11), inv(11), t(11;15), and t(10;11) found in 5 of the 11 patients had breakpoints in a small region from Ccl11-430 to Ccl11-526 at 11q22–q23.1. Furthermore, breakpoints for chromosome deletions at 11q21–q23 in 10 patients were located in the same region as that of translocations. A commonly deleted region among 8 patients was identified from Ccl11-526 to Ccl11-555 at 11q23.1. Fluorescence in situ hybridization analysis revealed that breakpoints for additive chromosome [add(11)] aberrations, which had additional material of unknown origin at 11q23 to 11q25 in 11 patients, were not located at 11q23 but rather at the more telomeric site of Ccl11-503 to VIJ
22072 at 11q25. These results indicated that the patients had several restricted breakpoint sites, which means that these chromosomal regions have recurrent oncogenes and tumor suppressor genes for pathogenesis for leukemia and lymphoma. |
| doi_str_mv | 10.1016/S0165-4608(00)00316-2 |
| format | Article |
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MLL/ALL-1 gene. The breakpoint in each patient was identified by fluorescence in situ hybridization using 21 cosmid probes and 2 YAC probes. Breakpoints for each “rearrangement” involving translocations such as t(1;11), t(2;11), inv(11), t(11;15), and t(10;11) found in 5 of the 11 patients had breakpoints in a small region from Ccl11-430 to Ccl11-526 at 11q22–q23.1. Furthermore, breakpoints for chromosome deletions at 11q21–q23 in 10 patients were located in the same region as that of translocations. A commonly deleted region among 8 patients was identified from Ccl11-526 to Ccl11-555 at 11q23.1. Fluorescence in situ hybridization analysis revealed that breakpoints for additive chromosome [add(11)] aberrations, which had additional material of unknown origin at 11q23 to 11q25 in 11 patients, were not located at 11q23 but rather at the more telomeric site of Ccl11-503 to VIJ
22072 at 11q25. These results indicated that the patients had several restricted breakpoint sites, which means that these chromosomal regions have recurrent oncogenes and tumor suppressor genes for pathogenesis for leukemia and lymphoma.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(00)00316-2</identifier><identifier>PMID: 11165319</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Child ; Chromosomes, Human, Pair 1 - genetics ; Chromosomes, Human, Pair 10 - genetics ; Chromosomes, Human, Pair 11 - genetics ; Female ; Gene Rearrangement, B-Lymphocyte - genetics ; Gene Rearrangement, T-Lymphocyte - genetics ; Genetic Markers ; Humans ; In Situ Hybridization, Fluorescence ; Leukemia, Myeloid - genetics ; Lymphoma, B-Cell - genetics ; Lymphoma, T-Cell - genetics ; Male ; Middle Aged ; Translocation, Genetic - genetics</subject><ispartof>Cancer genetics and cytogenetics, 2001, Vol.124 (1), p.27-35</ispartof><rights>2001 Elsevier Science Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-efa8a9d3910463595630089835a6cf41d2b08250319907f524d902c3ec2c38453</citedby><cites>FETCH-LOGICAL-c361t-efa8a9d3910463595630089835a6cf41d2b08250319907f524d902c3ec2c38453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-4608(00)00316-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11165319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Kimio</creatorcontrib><creatorcontrib>Eguchi, Mariko</creatorcontrib><creatorcontrib>Eguchi-Ishimae, Minenori</creatorcontrib><creatorcontrib>Hasegawa, Akira</creatorcontrib><creatorcontrib>Ohgami, Akiko</creatorcontrib><creatorcontrib>Kikuchi, Masahiro</creatorcontrib><creatorcontrib>Kyo, Taichi</creatorcontrib><creatorcontrib>Asaoku, Hideki</creatorcontrib><creatorcontrib>Dohy, Hiroo</creatorcontrib><creatorcontrib>Kamada, Nanao</creatorcontrib><title>Restricted chromosome breakpoint sites on 11q22–q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>We analyzed 32 patients with various hematological malignancies including acute myelocytic leukemia and non-Hodgkin lymphoma with a breakpoint at 11q22–q25 of chromosome 11, but who did not have rearrangements of the
MLL/ALL-1 gene. The breakpoint in each patient was identified by fluorescence in situ hybridization using 21 cosmid probes and 2 YAC probes. Breakpoints for each “rearrangement” involving translocations such as t(1;11), t(2;11), inv(11), t(11;15), and t(10;11) found in 5 of the 11 patients had breakpoints in a small region from Ccl11-430 to Ccl11-526 at 11q22–q23.1. Furthermore, breakpoints for chromosome deletions at 11q21–q23 in 10 patients were located in the same region as that of translocations. A commonly deleted region among 8 patients was identified from Ccl11-526 to Ccl11-555 at 11q23.1. Fluorescence in situ hybridization analysis revealed that breakpoints for additive chromosome [add(11)] aberrations, which had additional material of unknown origin at 11q23 to 11q25 in 11 patients, were not located at 11q23 but rather at the more telomeric site of Ccl11-503 to VIJ
22072 at 11q25. These results indicated that the patients had several restricted breakpoint sites, which means that these chromosomal regions have recurrent oncogenes and tumor suppressor genes for pathogenesis for leukemia and lymphoma.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Chromosomes, Human, Pair 10 - genetics</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Female</subject><subject>Gene Rearrangement, B-Lymphocyte - genetics</subject><subject>Gene Rearrangement, T-Lymphocyte - genetics</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, T-Cell - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Translocation, Genetic - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2OEzEQhS0EYsLAEUBeIVj0TNluO-0VGo34kxoh8bO2HHd1Yui2E9sZxI4DsOOGnARPEsGSTVlyvaqn-h4hjxlcMGDq8mMtsmkVdM8AngMIphp-hyxYtxRN20p1lyz-Ss7Ig5y_AMCSa3WfnDFWO4LpBfn5AXNJ3hUcqNukOMccZ6SrhPbrNvpQaPYFM42BMrbj_PePXzsuLhi1YTj8SOoDvbHJx32mG5xtiVNce2cnOtvJr4MNztcF33zZxH2h7_r-8qrvG0bXGJBWn5RsWOOMoTwk90Y7ZXx0es_J51cvP12_afr3r99eX_WNE4qVBkfbWT0IzaBVQmqpBECnOyGtcmPLBr6CjsuKRGtYjpK3gwbuBLpaulaKc_L0uHeb4m5fAZjZZ4fTZAPWM8wSpFa6FVUoj0KXYs4JR7NNfrbpu2FgbmMwhxjMLWMDYA4xGF7nnpwM9qsZh39TJ-5V8OIowHrmjcdkcqUUHA4-oStmiP4_Fn8ApuKWvQ</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Tanaka, Kimio</creator><creator>Eguchi, Mariko</creator><creator>Eguchi-Ishimae, Minenori</creator><creator>Hasegawa, Akira</creator><creator>Ohgami, Akiko</creator><creator>Kikuchi, Masahiro</creator><creator>Kyo, Taichi</creator><creator>Asaoku, Hideki</creator><creator>Dohy, Hiroo</creator><creator>Kamada, Nanao</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Restricted chromosome breakpoint sites on 11q22–q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement</title><author>Tanaka, Kimio ; Eguchi, Mariko ; Eguchi-Ishimae, Minenori ; Hasegawa, Akira ; Ohgami, Akiko ; Kikuchi, Masahiro ; Kyo, Taichi ; Asaoku, Hideki ; Dohy, Hiroo ; Kamada, Nanao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-efa8a9d3910463595630089835a6cf41d2b08250319907f524d902c3ec2c38453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Chromosomes, Human, Pair 10 - genetics</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Female</topic><topic>Gene Rearrangement, B-Lymphocyte - genetics</topic><topic>Gene Rearrangement, T-Lymphocyte - genetics</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, T-Cell - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Translocation, Genetic - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Kimio</creatorcontrib><creatorcontrib>Eguchi, Mariko</creatorcontrib><creatorcontrib>Eguchi-Ishimae, Minenori</creatorcontrib><creatorcontrib>Hasegawa, Akira</creatorcontrib><creatorcontrib>Ohgami, Akiko</creatorcontrib><creatorcontrib>Kikuchi, Masahiro</creatorcontrib><creatorcontrib>Kyo, Taichi</creatorcontrib><creatorcontrib>Asaoku, Hideki</creatorcontrib><creatorcontrib>Dohy, Hiroo</creatorcontrib><creatorcontrib>Kamada, Nanao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Kimio</au><au>Eguchi, Mariko</au><au>Eguchi-Ishimae, Minenori</au><au>Hasegawa, Akira</au><au>Ohgami, Akiko</au><au>Kikuchi, Masahiro</au><au>Kyo, Taichi</au><au>Asaoku, Hideki</au><au>Dohy, Hiroo</au><au>Kamada, Nanao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restricted chromosome breakpoint sites on 11q22–q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2001</date><risdate>2001</risdate><volume>124</volume><issue>1</issue><spage>27</spage><epage>35</epage><pages>27-35</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><abstract>We analyzed 32 patients with various hematological malignancies including acute myelocytic leukemia and non-Hodgkin lymphoma with a breakpoint at 11q22–q25 of chromosome 11, but who did not have rearrangements of the
MLL/ALL-1 gene. The breakpoint in each patient was identified by fluorescence in situ hybridization using 21 cosmid probes and 2 YAC probes. Breakpoints for each “rearrangement” involving translocations such as t(1;11), t(2;11), inv(11), t(11;15), and t(10;11) found in 5 of the 11 patients had breakpoints in a small region from Ccl11-430 to Ccl11-526 at 11q22–q23.1. Furthermore, breakpoints for chromosome deletions at 11q21–q23 in 10 patients were located in the same region as that of translocations. A commonly deleted region among 8 patients was identified from Ccl11-526 to Ccl11-555 at 11q23.1. Fluorescence in situ hybridization analysis revealed that breakpoints for additive chromosome [add(11)] aberrations, which had additional material of unknown origin at 11q23 to 11q25 in 11 patients, were not located at 11q23 but rather at the more telomeric site of Ccl11-503 to VIJ
22072 at 11q25. These results indicated that the patients had several restricted breakpoint sites, which means that these chromosomal regions have recurrent oncogenes and tumor suppressor genes for pathogenesis for leukemia and lymphoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11165319</pmid><doi>10.1016/S0165-4608(00)00316-2</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 2001, Vol.124 (1), p.27-35 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acute Disease Adult Aged Aged, 80 and over Child Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 10 - genetics Chromosomes, Human, Pair 11 - genetics Female Gene Rearrangement, B-Lymphocyte - genetics Gene Rearrangement, T-Lymphocyte - genetics Genetic Markers Humans In Situ Hybridization, Fluorescence Leukemia, Myeloid - genetics Lymphoma, B-Cell - genetics Lymphoma, T-Cell - genetics Male Middle Aged Translocation, Genetic - genetics |
| title | Restricted chromosome breakpoint sites on 11q22–q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement |
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