CpG oligodeoxynucleotide vaccination suppresses IgE induction but may fail to down-regulate ongoing IgE responses in mice

Antigen-specific IgE plays an important role in the pathogenesis of allergic disorders. Immunostimulatory CpG motifs (CpG) in bacterial DNA or synthesized oligodeoxynucleotides (ODN) are gaining recognition as potential immunomodulators for switching on protectiveTh1-mediated immunity and preventing...

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Veröffentlicht in:	International immunology 2001-01, Vol.13 (1), p.3-11
Hauptverfasser:	Peng, Zhikang, Wang, Hongsheng, Mao, Xiaojuan, HayGlass, Kent T., Simons, F. Estelle R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Aedes - immunology Allergens - administration & dosage Allergens - immunology allergy Animals CpG Islands - immunology cytokines Down-Regulation - immunology Female i.d. intradermal Immunoglobulin E - biosynthesis Immunosuppressive Agents - administration & dosage Injections, Intradermal Insect Proteins - administration & dosage Insect Proteins - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL ODN oligodeoxynucleotide oligodeoxynucleotides Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - immunology rAed a 1 recombinant Aed a 1 Recombinant Proteins - administration & dosage Recombinant Proteins - immunology Salivary Proteins and Peptides - administration & dosage Salivary Proteins and Peptides - immunology Th1Th2 vaccination Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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