One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype
OBJECTIVE: The study examined 1-year recovery and relapse rates for mania in subjects who met criteria for a prepubertal and early adolescent bipolar disorder phenotype. METHOD: Outpatients identified by consecutive new-case ascertainment were assessed by means of separate child and parent interview...
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| Veröffentlicht in: | The American journal of psychiatry 2001-02, Vol.158 (2), p.303-305 |
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| container_title | The American journal of psychiatry |
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| creator | Geller, Barbara Craney, James L. Bolhofner, Kristine DelBello, Melissa P. Williams, Marlene Zimerman, Betsy |
| description | OBJECTIVE: The study examined 1-year recovery and relapse rates for mania in subjects who met criteria for a prepubertal and early adolescent bipolar disorder phenotype. METHOD: Outpatients identified by consecutive new-case ascertainment were assessed by means of separate child and parent interviews, consensus conferences, and blind best estimates. The definition of the prepubertal and early adolescent bipolar disorder phenotype was DSM-IV mania with elation and or grandiosity as one criterion. RESULTS: Of 93 subjects seen at baseline, 89 were seen at 1 year (95.7% retention). The rate of recovery from mania was 37.1%, and the rate of relapse after recovery was 38.3%. No covariates were significantly associated with recovery or relapse. CONCLUSIONS: The low recovery and high relapse rates supported the study hypothesis of poor outcomes, which was made on the basis of similarity between the characteristics of the prepubertal and early adolescent bipolar disorder phenotype (long episode duration and high prevalence of mixed mania, psychosis, and rapid cycling) and those of severe bipolar disorder in adults. |
| doi_str_mv | 10.1176/appi.ajp.158.2.303 |
| format | Article |
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METHOD: Outpatients identified by consecutive new-case ascertainment were assessed by means of separate child and parent interviews, consensus conferences, and blind best estimates. The definition of the prepubertal and early adolescent bipolar disorder phenotype was DSM-IV mania with elation and or grandiosity as one criterion. RESULTS: Of 93 subjects seen at baseline, 89 were seen at 1 year (95.7% retention). The rate of recovery from mania was 37.1%, and the rate of relapse after recovery was 38.3%. No covariates were significantly associated with recovery or relapse. CONCLUSIONS: The low recovery and high relapse rates supported the study hypothesis of poor outcomes, which was made on the basis of similarity between the characteristics of the prepubertal and early adolescent bipolar disorder phenotype (long episode duration and high prevalence of mixed mania, psychosis, and rapid cycling) and those of severe bipolar disorder in adults.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.158.2.303</identifier><identifier>PMID: 11156815</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Bipolar affective disorder ; Bipolar Disorder - diagnosis ; Bipolar Disorder - genetics ; Bipolar Disorder - psychology ; Child ; Child clinical studies ; Children ; Effects ; Follow-Up Studies ; Followup studies ; Health care ; Humans ; Medical sciences ; Mental disorders ; Mood disorders ; Outcome Assessment (Health Care) ; Phenotype ; Prognosis ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Rates ; Recurrence ; Severity of Illness Index ; Teenagers</subject><ispartof>The American journal of psychiatry, 2001-02, Vol.158 (2), p.303-305</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Feb 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a425t-651a03dc40b2e4f84f3c2defd5b373d165ebdaa7ab74c70f60a2bf410cc676a53</citedby><cites>FETCH-LOGICAL-a425t-651a03dc40b2e4f84f3c2defd5b373d165ebdaa7ab74c70f60a2bf410cc676a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.158.2.303$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.158.2.303$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2842,21605,21606,21607,27901,27902,30977,77537,77542</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=872659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11156815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geller, Barbara</creatorcontrib><creatorcontrib>Craney, James L.</creatorcontrib><creatorcontrib>Bolhofner, Kristine</creatorcontrib><creatorcontrib>DelBello, Melissa P.</creatorcontrib><creatorcontrib>Williams, Marlene</creatorcontrib><creatorcontrib>Zimerman, Betsy</creatorcontrib><title>One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The study examined 1-year recovery and relapse rates for mania in subjects who met criteria for a prepubertal and early adolescent bipolar disorder phenotype. METHOD: Outpatients identified by consecutive new-case ascertainment were assessed by means of separate child and parent interviews, consensus conferences, and blind best estimates. The definition of the prepubertal and early adolescent bipolar disorder phenotype was DSM-IV mania with elation and or grandiosity as one criterion. RESULTS: Of 93 subjects seen at baseline, 89 were seen at 1 year (95.7% retention). The rate of recovery from mania was 37.1%, and the rate of relapse after recovery was 38.3%. No covariates were significantly associated with recovery or relapse. CONCLUSIONS: The low recovery and high relapse rates supported the study hypothesis of poor outcomes, which was made on the basis of similarity between the characteristics of the prepubertal and early adolescent bipolar disorder phenotype (long episode duration and high prevalence of mixed mania, psychosis, and rapid cycling) and those of severe bipolar disorder in adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Bipolar affective disorder</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar Disorder - psychology</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Children</subject><subject>Effects</subject><subject>Follow-Up Studies</subject><subject>Followup studies</subject><subject>Health care</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Mood disorders</subject><subject>Outcome Assessment (Health Care)</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Rates</subject><subject>Recurrence</subject><subject>Severity of Illness Index</subject><subject>Teenagers</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkV1rFDEUhoModq3-AS8kKHg323xn9rKu1QqFlqKoV-HM5Aw7S3YyJjPC_nvT7tKCF3oVDjzve054CHnN2ZJza85gHPslbMcl1_VSLCWTT8iCa6krK0T9lCwYY6JaafnjhLzIeVtGJq14Tk4459rUXC9Iuh6w-omQ6C228TemPYXBlyHAmJHewoSZxo6uN33wCQf6vZ82FOhNwnFuME0Q7gMXkMKenvsYMLc4TPRDP8ZQaj_2OSaPid5scIjTfsSX5FkHIeOr43tKvn26-Lq-rK6uP39Zn19VoISeKqM5MOlbxRqBqqtVJ1vhsfO6kVZ6bjQ2HsBCY1VrWWcYiKZTnLWtsQa0PCXvD71jir9mzJPb9eW2EGDAOGdnmV4prsV_QW1VbSSvC_j2L3Ab5zSUTzghmLLKWFsgcYDaFHNO2Lkx9TtIe8eZu_Pm7ry54s0Vb0644q2E3hyb52aH_jFyFFWAd0cAcguhSzC0fX7gaiuMXhXq7EDdr3g47h-L_wCn3bIf</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Geller, Barbara</creator><creator>Craney, James L.</creator><creator>Bolhofner, Kristine</creator><creator>DelBello, Melissa P.</creator><creator>Williams, Marlene</creator><creator>Zimerman, Betsy</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype</title><author>Geller, Barbara ; Craney, James L. ; Bolhofner, Kristine ; DelBello, Melissa P. ; Williams, Marlene ; Zimerman, Betsy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a425t-651a03dc40b2e4f84f3c2defd5b373d165ebdaa7ab74c70f60a2bf410cc676a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Bipolar affective disorder</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar Disorder - psychology</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Children</topic><topic>Effects</topic><topic>Follow-Up Studies</topic><topic>Followup studies</topic><topic>Health care</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>Mood disorders</topic><topic>Outcome Assessment (Health Care)</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Rates</topic><topic>Recurrence</topic><topic>Severity of Illness Index</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geller, Barbara</creatorcontrib><creatorcontrib>Craney, James L.</creatorcontrib><creatorcontrib>Bolhofner, Kristine</creatorcontrib><creatorcontrib>DelBello, Melissa P.</creatorcontrib><creatorcontrib>Williams, Marlene</creatorcontrib><creatorcontrib>Zimerman, Betsy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geller, Barbara</au><au>Craney, James L.</au><au>Bolhofner, Kristine</au><au>DelBello, Melissa P.</au><au>Williams, Marlene</au><au>Zimerman, Betsy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>158</volume><issue>2</issue><spage>303</spage><epage>305</epage><pages>303-305</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The study examined 1-year recovery and relapse rates for mania in subjects who met criteria for a prepubertal and early adolescent bipolar disorder phenotype. METHOD: Outpatients identified by consecutive new-case ascertainment were assessed by means of separate child and parent interviews, consensus conferences, and blind best estimates. The definition of the prepubertal and early adolescent bipolar disorder phenotype was DSM-IV mania with elation and or grandiosity as one criterion. RESULTS: Of 93 subjects seen at baseline, 89 were seen at 1 year (95.7% retention). The rate of recovery from mania was 37.1%, and the rate of relapse after recovery was 38.3%. No covariates were significantly associated with recovery or relapse. CONCLUSIONS: The low recovery and high relapse rates supported the study hypothesis of poor outcomes, which was made on the basis of similarity between the characteristics of the prepubertal and early adolescent bipolar disorder phenotype (long episode duration and high prevalence of mixed mania, psychosis, and rapid cycling) and those of severe bipolar disorder in adults.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>11156815</pmid><doi>10.1176/appi.ajp.158.2.303</doi><tpages>3</tpages></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Age Factors Biological and medical sciences Bipolar affective disorder Bipolar Disorder - diagnosis Bipolar Disorder - genetics Bipolar Disorder - psychology Child Child clinical studies Children Effects Follow-Up Studies Followup studies Health care Humans Medical sciences Mental disorders Mood disorders Outcome Assessment (Health Care) Phenotype Prognosis Psychiatric Status Rating Scales - statistics & numerical data Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rates Recurrence Severity of Illness Index Teenagers |
| title | One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype |
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