Glandular odontogenic cyst: absence of PTCH gene mutation
: Glandular odontogenic cyst (GOC) is a rare jawbone cyst of odontogenic origin. Human patched (PTCH) is a tumour suppressor gene that has been recently associated with signalling pathways during odontogenesis. Recently alterations of this gene were found on sporadic odontogenic keratocysts. This ev...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2001-02, Vol.30 (2), p.125-128 |
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| container_end_page | 128 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Barreto, Diele Carine Marco, Luiz Castro, Wagner Henriques Gomez, Ricardo Santiago |
| description | : Glandular odontogenic cyst (GOC) is a rare jawbone cyst of odontogenic origin. Human patched (PTCH) is a tumour suppressor gene that has been recently associated with signalling pathways during odontogenesis. Recently alterations of this gene were found on sporadic odontogenic keratocysts. This evidence, together with the biological behaviour similarities of both lesions, and the absence of reports on molecular analysis of GOC, led us to hypothesize that PTCH gene mutations may underlie the tumorigenesis of GOC. Therefore the aim of this study was to report one additional case of GOC and investigate the PTCH gene of the cyst. No mutations were found in the splicing and coding regions of the PTCH gene. In conclusion, the PTCH gene does not seem to be involved in GOC pathogenesis. |
| doi_str_mv | 10.1034/j.1600-0714.2001.300210.x |
| format | Article |
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Human patched (PTCH) is a tumour suppressor gene that has been recently associated with signalling pathways during odontogenesis. Recently alterations of this gene were found on sporadic odontogenic keratocysts. This evidence, together with the biological behaviour similarities of both lesions, and the absence of reports on molecular analysis of GOC, led us to hypothesize that PTCH gene mutations may underlie the tumorigenesis of GOC. Therefore the aim of this study was to report one additional case of GOC and investigate the PTCH gene of the cyst. No mutations were found in the splicing and coding regions of the PTCH gene. In conclusion, the PTCH gene does not seem to be involved in GOC pathogenesis.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1034/j.1600-0714.2001.300210.x</identifier><identifier>PMID: 11168858</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Aged ; Biological and medical sciences ; Dentistry ; Exons - genetics ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Gene Amplification ; glandular odontogenic cyst ; Humans ; Mandibular Diseases - genetics ; Mandibular Diseases - pathology ; Medical sciences ; Membrane Proteins - genetics ; Mutation - genetics ; Odontogenesis - genetics ; odontogenic cysts ; Odontogenic Cysts - genetics ; Odontogenic Cysts - pathology ; Otorhinolaryngology. Stomatology ; Patched Receptors ; Patched-1 Receptor ; PTCH ; Receptors, Cell Surface ; Sequence Analysis, DNA ; Signal Transduction - genetics ; Tumors</subject><ispartof>Journal of oral pathology & medicine, 2001-02, Vol.30 (2), p.125-128</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3980-83cd04f262bee97fb998455fb82b4cf2e6d7727594e594680df6f5018265fd093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0714.2001.300210.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0714.2001.300210.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=849125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11168858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barreto, Diele Carine</creatorcontrib><creatorcontrib>Marco, Luiz</creatorcontrib><creatorcontrib>Castro, Wagner Henriques</creatorcontrib><creatorcontrib>Gomez, Ricardo Santiago</creatorcontrib><title>Glandular odontogenic cyst: absence of PTCH gene mutation</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>: Glandular odontogenic cyst (GOC) is a rare jawbone cyst of odontogenic origin. Human patched (PTCH) is a tumour suppressor gene that has been recently associated with signalling pathways during odontogenesis. Recently alterations of this gene were found on sporadic odontogenic keratocysts. This evidence, together with the biological behaviour similarities of both lesions, and the absence of reports on molecular analysis of GOC, led us to hypothesize that PTCH gene mutations may underlie the tumorigenesis of GOC. Therefore the aim of this study was to report one additional case of GOC and investigate the PTCH gene of the cyst. No mutations were found in the splicing and coding regions of the PTCH gene. In conclusion, the PTCH gene does not seem to be involved in GOC pathogenesis.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Dentistry</subject><subject>Exons - genetics</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Gene Amplification</subject><subject>glandular odontogenic cyst</subject><subject>Humans</subject><subject>Mandibular Diseases - genetics</subject><subject>Mandibular Diseases - pathology</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Mutation - genetics</subject><subject>Odontogenesis - genetics</subject><subject>odontogenic cysts</subject><subject>Odontogenic Cysts - genetics</subject><subject>Odontogenic Cysts - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Patched Receptors</subject><subject>Patched-1 Receptor</subject><subject>PTCH</subject><subject>Receptors, Cell Surface</subject><subject>Sequence Analysis, DNA</subject><subject>Signal Transduction - genetics</subject><subject>Tumors</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAUhoMobk7_glQE7zpP0qRNvFKGTmWwXeh1SNNEOvoxmxa3f29Ky7z1IpzA-5wPHoRuMMwxRPR-O8cxQAgJpnMCgOcRAPHh_gRNj8kpmoIAGhKGyQRdOLf1ZBJRfI4mGOOYc8anSCwLVWVdoZqgzuqqrb9MletAH1z7EKjUmUqboLbB5mPxGvjMBGXXqjavq0t0ZlXhzNVYZ-jz5dlT4Wq9fFs8rUIdCQ4hj3QG1JKYpMaIxKZCcMqYTTlJqbbExFmSkIQJavyLOWQ2tgwwJzGzGYhohu6Gubum_u6Ma2WZO20Kf7epOycTYAJDTDwoBlA3tXONsXLX5KVqDhKD7L3JreztyN6O7L3JwZvc-97rcUmXlib76xxFeeB2BJTTqrCNqnTujhynAhPmqceB-skLc_j_fvm-3gz_6BcZHIan</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>Barreto, Diele Carine</creator><creator>Marco, Luiz</creator><creator>Castro, Wagner Henriques</creator><creator>Gomez, Ricardo Santiago</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200102</creationdate><title>Glandular odontogenic cyst: absence of PTCH gene mutation</title><author>Barreto, Diele Carine ; Marco, Luiz ; Castro, Wagner Henriques ; Gomez, Ricardo Santiago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3980-83cd04f262bee97fb998455fb82b4cf2e6d7727594e594680df6f5018265fd093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Dentistry</topic><topic>Exons - genetics</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Gene Amplification</topic><topic>glandular odontogenic cyst</topic><topic>Humans</topic><topic>Mandibular Diseases - genetics</topic><topic>Mandibular Diseases - pathology</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Mutation - genetics</topic><topic>Odontogenesis - genetics</topic><topic>odontogenic cysts</topic><topic>Odontogenic Cysts - genetics</topic><topic>Odontogenic Cysts - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Patched Receptors</topic><topic>Patched-1 Receptor</topic><topic>PTCH</topic><topic>Receptors, Cell Surface</topic><topic>Sequence Analysis, DNA</topic><topic>Signal Transduction - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barreto, Diele Carine</creatorcontrib><creatorcontrib>Marco, Luiz</creatorcontrib><creatorcontrib>Castro, Wagner Henriques</creatorcontrib><creatorcontrib>Gomez, Ricardo Santiago</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barreto, Diele Carine</au><au>Marco, Luiz</au><au>Castro, Wagner Henriques</au><au>Gomez, Ricardo Santiago</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glandular odontogenic cyst: absence of PTCH gene mutation</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2001-02</date><risdate>2001</risdate><volume>30</volume><issue>2</issue><spage>125</spage><epage>128</epage><pages>125-128</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>: Glandular odontogenic cyst (GOC) is a rare jawbone cyst of odontogenic origin. Human patched (PTCH) is a tumour suppressor gene that has been recently associated with signalling pathways during odontogenesis. Recently alterations of this gene were found on sporadic odontogenic keratocysts. This evidence, together with the biological behaviour similarities of both lesions, and the absence of reports on molecular analysis of GOC, led us to hypothesize that PTCH gene mutations may underlie the tumorigenesis of GOC. Therefore the aim of this study was to report one additional case of GOC and investigate the PTCH gene of the cyst. No mutations were found in the splicing and coding regions of the PTCH gene. In conclusion, the PTCH gene does not seem to be involved in GOC pathogenesis.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>11168858</pmid><doi>10.1034/j.1600-0714.2001.300210.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Dentistry Exons - genetics Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Gene Amplification glandular odontogenic cyst Humans Mandibular Diseases - genetics Mandibular Diseases - pathology Medical sciences Membrane Proteins - genetics Mutation - genetics Odontogenesis - genetics odontogenic cysts Odontogenic Cysts - genetics Odontogenic Cysts - pathology Otorhinolaryngology. Stomatology Patched Receptors Patched-1 Receptor PTCH Receptors, Cell Surface Sequence Analysis, DNA Signal Transduction - genetics Tumors |
| title | Glandular odontogenic cyst: absence of PTCH gene mutation |
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