Testing the fetal origins hypothesis in twins : the Birmingham twin study
To test whether the link between birthsize and raised blood pressure or glucose tolerance is due to genetic or intrauterine factors, we studied whether differences in birthweight between pairs of monozygous and dizygous twins are associated with adult differences in blood pressure and glucose tolera...
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| Veröffentlicht in: | Diabetologia 2001-01, Vol.44 (1), p.33-39 |
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| creator | BAIRD, J OSMOND, C MACGREGOR, A SNIEDER, H HALES, C. N PHILLIPS, D. I. W |
| description | To test whether the link between birthsize and raised blood pressure or glucose tolerance is due to genetic or intrauterine factors, we studied whether differences in birthweight between pairs of monozygous and dizygous twins are associated with adult differences in blood pressure and glucose tolerance.
A sample of 58 monozygous and 140 dizygous twins were identified from a register of births in Birmingham, United Kingdom, between 1950 and 1954. The twins had their blood pressure measured and underwent an oral glucose tolerance test.
There were no statistically significant associations between birthweight, length or ponderal index, and either blood pressure or glucose tolerance in the twins. Although there were substantial within-pair differences in birthweight between monozygous and dizygous twin pairs, these differences did not correlate with the adult outcomes. Monozygous correlations, however, for both blood pressure and glucose tolerance were statistically significantly higher than dizygous correlations and a quantitative genetic model suggested statistically significant heritability for these traits. In contrast correlations of birthsize were similar in monozygous and dizygous pairs suggesting only a small genetic component in determining fetal size.
Our results show that birthsize in twins does not predict adult blood pressure or glucose tolerance. We also suggest that shared genetic determinants for fetal growth and adult outcomes are not likely to be prevalent or powerful. |
| doi_str_mv | 10.1007/s001250051577 |
| format | Article |
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A sample of 58 monozygous and 140 dizygous twins were identified from a register of births in Birmingham, United Kingdom, between 1950 and 1954. The twins had their blood pressure measured and underwent an oral glucose tolerance test.
There were no statistically significant associations between birthweight, length or ponderal index, and either blood pressure or glucose tolerance in the twins. Although there were substantial within-pair differences in birthweight between monozygous and dizygous twin pairs, these differences did not correlate with the adult outcomes. Monozygous correlations, however, for both blood pressure and glucose tolerance were statistically significantly higher than dizygous correlations and a quantitative genetic model suggested statistically significant heritability for these traits. In contrast correlations of birthsize were similar in monozygous and dizygous pairs suggesting only a small genetic component in determining fetal size.
Our results show that birthsize in twins does not predict adult blood pressure or glucose tolerance. We also suggest that shared genetic determinants for fetal growth and adult outcomes are not likely to be prevalent or powerful.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s001250051577</identifier><identifier>PMID: 11206409</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Birth Weight ; Births ; Blood Glucose - analysis ; Blood pressure ; Blood Pressure - genetics ; Body Constitution ; Body Mass Index ; Cardiovascular disease ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fasting ; Gestational Age ; Glucose ; Glucose Intolerance - genetics ; Glucose Tolerance Test ; Hospitals ; Humans ; Hypotheses ; Influence ; Insulin - blood ; Insulin resistance ; Medical sciences ; Metabolism ; Obesity ; Quantitative genetics ; Twin studies ; Twins ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Diabetologia, 2001-01, Vol.44 (1), p.33-39</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-340a258ab22e60140f59e39aa1fee6a4a58326331697a83cef0c161a4f5892c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=909695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11206409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAIRD, J</creatorcontrib><creatorcontrib>OSMOND, C</creatorcontrib><creatorcontrib>MACGREGOR, A</creatorcontrib><creatorcontrib>SNIEDER, H</creatorcontrib><creatorcontrib>HALES, C. N</creatorcontrib><creatorcontrib>PHILLIPS, D. I. W</creatorcontrib><title>Testing the fetal origins hypothesis in twins : the Birmingham twin study</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>To test whether the link between birthsize and raised blood pressure or glucose tolerance is due to genetic or intrauterine factors, we studied whether differences in birthweight between pairs of monozygous and dizygous twins are associated with adult differences in blood pressure and glucose tolerance.
A sample of 58 monozygous and 140 dizygous twins were identified from a register of births in Birmingham, United Kingdom, between 1950 and 1954. The twins had their blood pressure measured and underwent an oral glucose tolerance test.
There were no statistically significant associations between birthweight, length or ponderal index, and either blood pressure or glucose tolerance in the twins. Although there were substantial within-pair differences in birthweight between monozygous and dizygous twin pairs, these differences did not correlate with the adult outcomes. Monozygous correlations, however, for both blood pressure and glucose tolerance were statistically significantly higher than dizygous correlations and a quantitative genetic model suggested statistically significant heritability for these traits. In contrast correlations of birthsize were similar in monozygous and dizygous pairs suggesting only a small genetic component in determining fetal size.
Our results show that birthsize in twins does not predict adult blood pressure or glucose tolerance. We also suggest that shared genetic determinants for fetal growth and adult outcomes are not likely to be prevalent or powerful.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Births</subject><subject>Blood Glucose - analysis</subject><subject>Blood pressure</subject><subject>Blood Pressure - genetics</subject><subject>Body Constitution</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fasting</subject><subject>Gestational Age</subject><subject>Glucose</subject><subject>Glucose Intolerance - genetics</subject><subject>Glucose Tolerance Test</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Influence</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Quantitative genetics</subject><subject>Twin studies</subject><subject>Twins</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0EtLAzEUBeAgiq2PpVsZFNyN3jwncafFR6HgpoK7IU0zbco8ajKD9N-btoOiq8DJdy-Xg9AFhlsMkN0FAEw4AMc8yw7QEDNKUmBEHqLh9ivFUnwM0EkIKwCgnIljNMCYgGCghmg8taF19SJplzYpbKvLpPFu4eqQLDfrJqbBhcTVSfu1ze537tH5Ks4sdbWLk9B2880ZOip0Gex5_56i9-en6eg1nby9jEcPk9QwptqUMtCESz0jxArADAquLFVa48JaoZnmkhJBKRYq05IaW4DBAmtWcKmIkfQU3ez3rn3z2cXr88oFY8tS17bpQp4BV7EOGuHVP7hqOl_H23KCqWSMSx5RukfGNyF4W-Rr7yrtNzmGfFtw_qfg6C_7pd2ssvNf3TcawXUPdDC6LLyujQs_ToESitNv6DSANA</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>BAIRD, J</creator><creator>OSMOND, C</creator><creator>MACGREGOR, A</creator><creator>SNIEDER, H</creator><creator>HALES, C. 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W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-340a258ab22e60140f59e39aa1fee6a4a58326331697a83cef0c161a4f5892c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Births</topic><topic>Blood Glucose - analysis</topic><topic>Blood pressure</topic><topic>Blood Pressure - genetics</topic><topic>Body Constitution</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fasting</topic><topic>Gestational Age</topic><topic>Glucose</topic><topic>Glucose Intolerance - genetics</topic><topic>Glucose Tolerance Test</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Influence</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Quantitative genetics</topic><topic>Twin studies</topic><topic>Twins</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAIRD, J</creatorcontrib><creatorcontrib>OSMOND, C</creatorcontrib><creatorcontrib>MACGREGOR, A</creatorcontrib><creatorcontrib>SNIEDER, H</creatorcontrib><creatorcontrib>HALES, C. N</creatorcontrib><creatorcontrib>PHILLIPS, D. I. 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N</au><au>PHILLIPS, D. I. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testing the fetal origins hypothesis in twins : the Birmingham twin study</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>44</volume><issue>1</issue><spage>33</spage><epage>39</epage><pages>33-39</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>To test whether the link between birthsize and raised blood pressure or glucose tolerance is due to genetic or intrauterine factors, we studied whether differences in birthweight between pairs of monozygous and dizygous twins are associated with adult differences in blood pressure and glucose tolerance.
A sample of 58 monozygous and 140 dizygous twins were identified from a register of births in Birmingham, United Kingdom, between 1950 and 1954. The twins had their blood pressure measured and underwent an oral glucose tolerance test.
There were no statistically significant associations between birthweight, length or ponderal index, and either blood pressure or glucose tolerance in the twins. Although there were substantial within-pair differences in birthweight between monozygous and dizygous twin pairs, these differences did not correlate with the adult outcomes. Monozygous correlations, however, for both blood pressure and glucose tolerance were statistically significantly higher than dizygous correlations and a quantitative genetic model suggested statistically significant heritability for these traits. In contrast correlations of birthsize were similar in monozygous and dizygous pairs suggesting only a small genetic component in determining fetal size.
Our results show that birthsize in twins does not predict adult blood pressure or glucose tolerance. We also suggest that shared genetic determinants for fetal growth and adult outcomes are not likely to be prevalent or powerful.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11206409</pmid><doi>10.1007/s001250051577</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Birth Weight Births Blood Glucose - analysis Blood pressure Blood Pressure - genetics Body Constitution Body Mass Index Cardiovascular disease Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Gestational Age Glucose Glucose Intolerance - genetics Glucose Tolerance Test Hospitals Humans Hypotheses Influence Insulin - blood Insulin resistance Medical sciences Metabolism Obesity Quantitative genetics Twin studies Twins Twins, Dizygotic Twins, Monozygotic |
| title | Testing the fetal origins hypothesis in twins : the Birmingham twin study |
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