Genome-Wide Analysis of Developmental and Sex-Regulated Gene Expression Profiles in Caenorhabditis elegans
We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18,967 genes currently annotated in the Caenorhabditis elegans genome. These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with differ...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2001-01, Vol.98 (1), p.218-223 |
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| creator | Jiang, Min Ryu, Jubin Kiraly, Monika Duke, Kyle Reinke, Valerie Kim, Stuart K. |
| description | We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18,967 genes currently annotated in the Caenorhabditis elegans genome. These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development, from eggs through adulthood. These expression data can help reveal when a gene may act during development. We also compared gene expression in males to that of hermaphrodites and found a total of 2,171 sex-regulated genes (P < 0.05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior. |
| doi_str_mv | 10.1073/pnas.011520898 |
| format | Article |
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These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development, from eggs through adulthood. These expression data can help reveal when a gene may act during development. We also compared gene expression in males to that of hermaphrodites and found a total of 2,171 sex-regulated genes (P < 0.05). 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These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development, from eggs through adulthood. These expression data can help reveal when a gene may act during development. We also compared gene expression in males to that of hermaphrodites and found a total of 2,171 sex-regulated genes (P < 0.05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior.</description><subject>Aging - genetics</subject><subject>Animals</subject><subject>Biological Sciences</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - embryology</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Cyclins - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>Disorders of Sex Development - genetics</subject><subject>DNA</subject><subject>DNA microarrays</subject><subject>Embryos</subject><subject>Female</subject><subject>Gender</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Genes, Helminth - genetics</subject><subject>Genes, Retinoblastoma - genetics</subject><subject>Genetics</subject><subject>Genome</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Germ cells</subject><subject>Larvae</subject><subject>Larval development</subject><subject>Male</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>RNA</subject><subject>Sex Characteristics</subject><subject>Sex Differentiation - genetics</subject><subject>Signal Transduction - genetics</subject><subject>Standard deviation</subject><subject>Transcription Factors - genetics</subject><subject>Wnt Proteins</subject><subject>Zebrafish Proteins</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhSMEotPClhVCFhLsUq4TO7YlNtVQClIlEA-xtJz4ZuqRY6dxUk3_fY0YhscCVldX5ztH91EUTyicUhD1qzGYdAqU8gqkkveKFQVFy4YpuF-sACpRSlaxo-I4pS0AKC7hYXFEKa0Zp2JVbC8wxAHLb84iOQvG3yaXSOzJG7xBH8cBw2w8McGSz7grP-Fm8WZGS7IPyflunDAlFwP5OMXeeUzEBbI2OXS6Mq11c05DjxsT0qPiQW98wsf7elJ8fXv-Zf2uvPxw8X59dll2DMRcGgFUYQu24U1l-1pa1rWqNVJgpxpoK9EYQxvKja3rHjnLvZBtx5GCaayoT4rXP3LHpR3QdnmDyXg9Tm4w062Oxuk_leCu9CbeaMq4oNn-cm-f4vWCadaDSx16bwLGJWkBXCrF6_-CVAjWVPAdfP4XuI3LlG-ddAW0llKKKkPPfp_6MO7PV2XgxR7ILz_ISmqqKyp1v3g_427O3NN_cL_kbZrjdNBr4CwfvL4DfQ-3_w</recordid><startdate>20010102</startdate><enddate>20010102</enddate><creator>Jiang, Min</creator><creator>Ryu, Jubin</creator><creator>Kiraly, Monika</creator><creator>Duke, Kyle</creator><creator>Reinke, Valerie</creator><creator>Kim, Stuart K.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010102</creationdate><title>Genome-Wide Analysis of Developmental and Sex-Regulated Gene Expression Profiles in Caenorhabditis elegans</title><author>Jiang, Min ; Ryu, Jubin ; Kiraly, Monika ; Duke, Kyle ; Reinke, Valerie ; Kim, Stuart K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-a7019eb0d6562df38d4cb9ba87ec960b276aa1615ad33fe5476a78bc5e10a6d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aging - genetics</topic><topic>Animals</topic><topic>Biological Sciences</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - embryology</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - growth & development</topic><topic>Cyclins - genetics</topic><topic>Deoxyribonucleic acid</topic><topic>Disorders of Sex Development - genetics</topic><topic>DNA</topic><topic>DNA microarrays</topic><topic>Embryos</topic><topic>Female</topic><topic>Gender</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Genes, Helminth - genetics</topic><topic>Genes, Retinoblastoma - genetics</topic><topic>Genetics</topic><topic>Genome</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Germ cells</topic><topic>Larvae</topic><topic>Larval development</topic><topic>Male</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>RNA</topic><topic>Sex Characteristics</topic><topic>Sex Differentiation - genetics</topic><topic>Signal Transduction - genetics</topic><topic>Standard deviation</topic><topic>Transcription Factors - genetics</topic><topic>Wnt Proteins</topic><topic>Zebrafish Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Min</creatorcontrib><creatorcontrib>Ryu, Jubin</creatorcontrib><creatorcontrib>Kiraly, Monika</creatorcontrib><creatorcontrib>Duke, Kyle</creatorcontrib><creatorcontrib>Reinke, Valerie</creatorcontrib><creatorcontrib>Kim, Stuart K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Min</au><au>Ryu, Jubin</au><au>Kiraly, Monika</au><au>Duke, Kyle</au><au>Reinke, Valerie</au><au>Kim, Stuart K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-Wide Analysis of Developmental and Sex-Regulated Gene Expression Profiles in Caenorhabditis elegans</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2001-01-02</date><risdate>2001</risdate><volume>98</volume><issue>1</issue><spage>218</spage><epage>223</epage><pages>218-223</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18,967 genes currently annotated in the Caenorhabditis elegans genome. 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| subjects | Aging - genetics Animals Biological Sciences Caenorhabditis elegans Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Cyclins - genetics Deoxyribonucleic acid Disorders of Sex Development - genetics DNA DNA microarrays Embryos Female Gender Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Genes Genes, Helminth - genetics Genes, Retinoblastoma - genetics Genetics Genome Genomes Genomics Germ cells Larvae Larval development Male Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins - genetics RNA Sex Characteristics Sex Differentiation - genetics Signal Transduction - genetics Standard deviation Transcription Factors - genetics Wnt Proteins Zebrafish Proteins |
| title | Genome-Wide Analysis of Developmental and Sex-Regulated Gene Expression Profiles in Caenorhabditis elegans |
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