Does angina the week before protect against first myocardial infarction in elderly patients?
Mortality rates for coronary artery disease are greater in elderly patients. Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against ischemia, this effect has not been well documented in older patients. This study investigated whether ang...
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| Veröffentlicht in: | The American journal of cardiology 2001, Vol.87 (1), p.11-15 |
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| container_title | The American journal of cardiology |
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| creator | Navarro, Manuel Jiménez Gómez-Doblas, Juan José Alonso-Briales, Juan Garcı́a, José Marı́a Hernández Gómez, Gemma Alcántara, Angel Garcı́a Rodriguez-Bailón, Isabel Barrera, Alberto Montiel, Angel Caliani, Juan S.Espinosa de Teresa, Eduardo |
| description | Mortality rates for coronary artery disease are greater in elderly patients. Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against ischemia, this effect has not been well documented in older patients. This study investigated whether angina 1 week before a first MI provides protection in this group of patients. A total of 290 consecutive elderly (>64 years old, n = 143) and adult patients ( |
| doi_str_mv | 10.1016/S0002-9149(00)01264-9 |
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Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against ischemia, this effect has not been well documented in older patients. This study investigated whether angina 1 week before a first MI provides protection in this group of patients. A total of 290 consecutive elderly (>64 years old, n = 143) and adult patients (<65 years old, n = 147) with a first MI were examined to assess the effect of preceding angina on the short- and long-term prognosis. Elderly patients with a history of prodromal angina were less likely than those without angina to experience in-hospital death, heart failure, or the combined end point of in-hospital death and heart failure (6% vs 20.4%, p = 0.02; 10% vs 23.7%, p = 0.07; 14% vs 32.3%, p = 0.01, respectively). Left ventricular function was more frequently depressed (ejection fraction <40%) in elderly patients without (44.8%) than with (26%, p = 0.04) preinfarction angina, and the incidence of arrhythmias (complete heart block and ventricular fibrillation) was greater in the former group (16.1% vs 4%, p = 0.03). Multivariate analysis confirmed that the presence of preinfarction angina was an independent predictor of in-hospital death and heart failure in older patients (odds ratio 0.28, p = 0.009). The occurrence of angina 1 week before a first MI may confer protection against in-hospital adverse outcomes, and may preserve left ventricular function in older patients.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(00)01264-9</identifier><identifier>PMID: 11137826</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Angina Pectoris - complications ; Angina Pectoris - physiopathology ; Arrhythmias, Cardiac - complications ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary heart disease ; Female ; Follow-Up Studies ; Heart ; Heart attacks ; Hospital Mortality ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Older people ; Prevention ; Prognosis ; Regression Analysis ; Retrospective Studies ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>The American journal of cardiology, 2001, Vol.87 (1), p.11-15</ispartof><rights>2001 Excerpta Medica Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against ischemia, this effect has not been well documented in older patients. This study investigated whether angina 1 week before a first MI provides protection in this group of patients. A total of 290 consecutive elderly (>64 years old, n = 143) and adult patients (<65 years old, n = 147) with a first MI were examined to assess the effect of preceding angina on the short- and long-term prognosis. Elderly patients with a history of prodromal angina were less likely than those without angina to experience in-hospital death, heart failure, or the combined end point of in-hospital death and heart failure (6% vs 20.4%, p = 0.02; 10% vs 23.7%, p = 0.07; 14% vs 32.3%, p = 0.01, respectively). Left ventricular function was more frequently depressed (ejection fraction <40%) in elderly patients without (44.8%) than with (26%, p = 0.04) preinfarction angina, and the incidence of arrhythmias (complete heart block and ventricular fibrillation) was greater in the former group (16.1% vs 4%, p = 0.03). Multivariate analysis confirmed that the presence of preinfarction angina was an independent predictor of in-hospital death and heart failure in older patients (odds ratio 0.28, p = 0.009). The occurrence of angina 1 week before a first MI may confer protection against in-hospital adverse outcomes, and may preserve left ventricular function in older patients.</description><subject>Aged</subject><subject>Angina Pectoris - complications</subject><subject>Angina Pectoris - physiopathology</subject><subject>Arrhythmias, Cardiac - complications</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Older people</subject><subject>Prevention</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rVDEQhkNR2rX2J7QEBdGLo0nOSXJyVaR-QsEL9a4QcpJJTXs22SZZZf-92e5SoTfeTGbgmeHlCUKnlLylhIp33wkhrFN0UK8JeUMoE0OnDtCCjlJ1VNH-CVo8IEfoWSk3baSUi0N0RCnt5cjEAl19SFCwidchGlx_Af4DcIsn8CkDXuVUwVZsrk2IpWIfcqvLTbImu2BmHKI32daQYmsxzA7yvMErUwPEWs6fo6fezAVO9u8x-vnp44-LL93lt89fL95fdnYYWe28Y54o4HIgo2fOTpIPYKeBmtFKAMup527yVjjRcy65E1L6fpoUFUSxSfTH6NXubgt8t4ZS9TIUC_NsIqR10ZLwUXAyNPDFI_AmrXNs2TTrSS_YoFiD-A6yOZWSwetVDkuTN5oSvXWv793rrVhNiL53r1XbO9sfX09LcP-29rIb8HIPmGLN7LOJNpQHbuQ9k9uM5zsKmrHfAbIutum04EJun6FdCv8J8he_lqBZ</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Navarro, Manuel Jiménez</creator><creator>Gómez-Doblas, Juan José</creator><creator>Alonso-Briales, Juan</creator><creator>Garcı́a, José Marı́a Hernández</creator><creator>Gómez, Gemma</creator><creator>Alcántara, Angel Garcı́a</creator><creator>Rodriguez-Bailón, Isabel</creator><creator>Barrera, Alberto</creator><creator>Montiel, Angel</creator><creator>Caliani, Juan S.Espinosa</creator><creator>de Teresa, Eduardo</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Does angina the week before protect against first myocardial infarction in elderly patients?</title><author>Navarro, Manuel Jiménez ; Gómez-Doblas, Juan José ; Alonso-Briales, Juan ; Garcı́a, José Marı́a Hernández ; Gómez, Gemma ; Alcántara, Angel Garcı́a ; Rodriguez-Bailón, Isabel ; Barrera, Alberto ; Montiel, Angel ; Caliani, Juan S.Espinosa ; de Teresa, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-fd2f09e57408f2dcb754ecb41a8c7eec51f5dbfc6d635575d677f3bb916092b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Angina Pectoris - complications</topic><topic>Angina Pectoris - physiopathology</topic><topic>Arrhythmias, Cardiac - complications</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Older people</topic><topic>Prevention</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Navarro, Manuel Jiménez</creatorcontrib><creatorcontrib>Gómez-Doblas, Juan José</creatorcontrib><creatorcontrib>Alonso-Briales, Juan</creatorcontrib><creatorcontrib>Garcı́a, José Marı́a Hernández</creatorcontrib><creatorcontrib>Gómez, Gemma</creatorcontrib><creatorcontrib>Alcántara, Angel Garcı́a</creatorcontrib><creatorcontrib>Rodriguez-Bailón, Isabel</creatorcontrib><creatorcontrib>Barrera, Alberto</creatorcontrib><creatorcontrib>Montiel, Angel</creatorcontrib><creatorcontrib>Caliani, Juan S.Espinosa</creatorcontrib><creatorcontrib>de Teresa, Eduardo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Navarro, Manuel Jiménez</au><au>Gómez-Doblas, Juan José</au><au>Alonso-Briales, Juan</au><au>Garcı́a, José Marı́a Hernández</au><au>Gómez, Gemma</au><au>Alcántara, Angel Garcı́a</au><au>Rodriguez-Bailón, Isabel</au><au>Barrera, Alberto</au><au>Montiel, Angel</au><au>Caliani, Juan S.Espinosa</au><au>de Teresa, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does angina the week before protect against first myocardial infarction in elderly patients?</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2001</date><risdate>2001</risdate><volume>87</volume><issue>1</issue><spage>11</spage><epage>15</epage><pages>11-15</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Mortality rates for coronary artery disease are greater in elderly patients. Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against ischemia, this effect has not been well documented in older patients. This study investigated whether angina 1 week before a first MI provides protection in this group of patients. A total of 290 consecutive elderly (>64 years old, n = 143) and adult patients (<65 years old, n = 147) with a first MI were examined to assess the effect of preceding angina on the short- and long-term prognosis. Elderly patients with a history of prodromal angina were less likely than those without angina to experience in-hospital death, heart failure, or the combined end point of in-hospital death and heart failure (6% vs 20.4%, p = 0.02; 10% vs 23.7%, p = 0.07; 14% vs 32.3%, p = 0.01, respectively). Left ventricular function was more frequently depressed (ejection fraction <40%) in elderly patients without (44.8%) than with (26%, p = 0.04) preinfarction angina, and the incidence of arrhythmias (complete heart block and ventricular fibrillation) was greater in the former group (16.1% vs 4%, p = 0.03). Multivariate analysis confirmed that the presence of preinfarction angina was an independent predictor of in-hospital death and heart failure in older patients (odds ratio 0.28, p = 0.009). The occurrence of angina 1 week before a first MI may confer protection against in-hospital adverse outcomes, and may preserve left ventricular function in older patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11137826</pmid><doi>10.1016/S0002-9149(00)01264-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Angina Pectoris - complications Angina Pectoris - physiopathology Arrhythmias, Cardiac - complications Biological and medical sciences Cardiology. Vascular system Coronary heart disease Female Follow-Up Studies Heart Heart attacks Hospital Mortality Humans Male Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - mortality Myocardial Infarction - physiopathology Older people Prevention Prognosis Regression Analysis Retrospective Studies Ventricular Dysfunction, Left - physiopathology |
| title | Does angina the week before protect against first myocardial infarction in elderly patients? |
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