Reversal of LRP‐associated drug resistance in colon carcinoma sw‐620 cells

Resistance to multiple drugs is mediated by lung resistance‐related protein (LRP) as well as P‐glycoprotein (P‐gp) and multidrug resistance protein (MRP). The levels of expression of LRP mRNA and LRP in a human colon carcinoma cell line, SW‐620, were increased by the differentiation‐inducing agent,...

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Veröffentlicht in:	International journal of cancer 2001-01, Vol.91 (1), p.126-131
Hauptverfasser:	Kitazono, Masaki, Okumura, Hiroshi, Ikeda, Ryuji, Sumizawa, Tomoyuki, Furukawa, Tatsuhiko, Nagayama, Shuichi, Seto, Kiyotomo, Aikou, Takashi, Akiyama, Shin‐ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Benzylisoquinolines Biological and medical sciences Butyrates - pharmacology Carcinoma - drug therapy Cell Nucleus - metabolism Colonic Neoplasms - drug therapy Coloring Agents - pharmacology Cyclic P-Oxides - pharmacology Cytoplasm - metabolism Dose-Response Relationship, Drug Doxorubicin - pharmacology Drug Resistance, Neoplasm Etoposide - pharmacology General aspects Humans LRP MDR Medical sciences Microscopy, Fluorescence MRP NaB Neoplasm Proteins - metabolism Nicotinic Acids - pharmacology PAK‐104 Pharmacology. Drug treatments P‐gp reversal RNA, Catalytic - metabolism Tetrazolium Salts - pharmacology Thiazoles - pharmacology Time Factors Tumor Cells, Cultured Vault Ribonucleoprotein Particles - metabolism
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