Distribution of Gacyclidine Enantiomers after Experimental Spinal Cord Injury in Rats: Possible Involvement of an Active Transport System

The pharmacokinetics of gacyclidine enantiomers, a noncompetitive N‐methyl‐d‐aspartate (NMDA) antagonist, were studied in plasma and spinal cord extracellular fluid (ECF) after experimental spinal cord injury in rats. Spinal cord trauma was produced by introducing an inflatable balloon in the dorsal...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2001-01, Vol.90 (1), p.70-78
Hauptverfasser:	Hoizey, Guillaume, Kaltenbach, Matthieu L., Dukic, Sylvain, Lamiable, Denis, Lallemand, Aude, Millart, Hervé, D'Arbigny, Pierre, Vistelle, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport, Active Calibration Cyclohexanes - pharmacokinetics Cyclohexenes Disease Models, Animal Dose-Response Relationship, Drug enantiomers extracellular fluid gacyclidine Glutamatergic system (aspartate and other excitatory aminoacids) Male Medical sciences microdialysis Neuropharmacology Neuroprotective Agents - pharmacokinetics Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Piperidines - pharmacokinetics Protein Binding - drug effects Rats Rats, Wistar Spinal Cord Injuries - metabolism spinal cord injury Stereoisomerism Tissue Distribution
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