Expression of Ki-67 in Cervical Epithelial Cells in Preneoplastic Lesions of Patients with AIDS
The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in women with AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patie...
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| Veröffentlicht in: | Gynecologic and obstetric investigation 2001-01, Vol.51 (1), p.51-54 |
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| container_title | Gynecologic and obstetric investigation |
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| creator | Calore, Edenilson Eduardo Cavaliere, Maria José Perez Calore, Nilda Maria de Souza Dias, Suzana Paes dos Santos, Regina Vilela-de-Almeida, Lis |
| description | The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in women with AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patients and 18 Lo-CIN and 14 Hi-CIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 ± 10.44) as compared with Lo-CIN of general-population women (mean 17.08 ± 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the Hi-CIN of AIDS patients and of patients from the general population (p > 0.05). We conclude that the proliferative potential of cervical cells in Lo-CIN – as studied by the expression of the proliferation marker Ki-67 – is higher in AIDS patients than in the general population. |
| doi_str_mv | 10.1159/000052891 |
| format | Article |
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We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patients and 18 Lo-CIN and 14 Hi-CIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 ± 10.44) as compared with Lo-CIN of general-population women (mean 17.08 ± 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the Hi-CIN of AIDS patients and of patients from the general population (p > 0.05). We conclude that the proliferative potential of cervical cells in Lo-CIN – as studied by the expression of the proliferation marker Ki-67 – is higher in AIDS patients than in the general population.</description><identifier>ISSN: 0378-7346</identifier><identifier>EISSN: 1423-002X</identifier><identifier>DOI: 10.1159/000052891</identifier><identifier>PMID: 11150876</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Adolescent ; Adult ; Biological and medical sciences ; Cell Nucleus - chemistry ; Cervical Intraepithelial Neoplasia - chemistry ; Cervical Intraepithelial Neoplasia - complications ; Cervix Uteri - chemistry ; Cervix Uteri - ultrastructure ; Epithelial Cells - chemistry ; Epithelial Cells - ultrastructure ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Ki-67 Antigen - analysis ; Medical sciences ; Original Paper ; Retrospective Studies ; Tumors</subject><ispartof>Gynecologic and obstetric investigation, 2001-01, Vol.51 (1), p.51-54</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 S. Karger AG, Basel.</rights><rights>Copyright (c) 2001 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-c707ba8b9d2b2674cc48a56ba11af9545a8cdfcc98da247c64da61cbe57bdb0b3</citedby><cites>FETCH-LOGICAL-c414t-c707ba8b9d2b2674cc48a56ba11af9545a8cdfcc98da247c64da61cbe57bdb0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=858373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11150876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calore, Edenilson Eduardo</creatorcontrib><creatorcontrib>Cavaliere, Maria José</creatorcontrib><creatorcontrib>Perez Calore, Nilda Maria</creatorcontrib><creatorcontrib>de Souza Dias, Suzana</creatorcontrib><creatorcontrib>Paes dos Santos, Regina</creatorcontrib><creatorcontrib>Vilela-de-Almeida, Lis</creatorcontrib><title>Expression of Ki-67 in Cervical Epithelial Cells in Preneoplastic Lesions of Patients with AIDS</title><title>Gynecologic and obstetric investigation</title><addtitle>Gynecol Obstet Invest</addtitle><description>The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in women with AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patients and 18 Lo-CIN and 14 Hi-CIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 ± 10.44) as compared with Lo-CIN of general-population women (mean 17.08 ± 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the Hi-CIN of AIDS patients and of patients from the general population (p > 0.05). We conclude that the proliferative potential of cervical cells in Lo-CIN – as studied by the expression of the proliferation marker Ki-67 – is higher in AIDS patients than in the general population.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - chemistry</subject><subject>Cervical Intraepithelial Neoplasia - chemistry</subject><subject>Cervical Intraepithelial Neoplasia - complications</subject><subject>Cervix Uteri - chemistry</subject><subject>Cervix Uteri - ultrastructure</subject><subject>Epithelial Cells - chemistry</subject><subject>Epithelial Cells - ultrastructure</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>Medical sciences</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>0378-7346</issn><issn>1423-002X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkd1LHDEUxYO06FZ96HOhBAtCH0aTTL7mUcatXbqgoIJvIclkNHZ2Zkxmqv3vm3GXFUqhebmB-zs3J_cA8BGjE4xZcYrSYUQWeAfMMCV5hhC5ewdmKBcyEznle-BDjI8IJVjSXbCHkwxJwWdAzV_64GL0XQu7Gv7wGRfQt7B04Ze3uoHz3g8PrvHpWrqmiVPzKrjWdX2j4-AtXLpJHSf5lR68a4cIn5MIni3Orw_A-1o30R1u6j64_Ta_Kb9ny8uLRXm2zCzFdMisQMJoaYqKGMIFtZZKzbjRGOu6YJRpaava2kJWmlBhOa00x9Y4JkxlkMn3wfF6bh-6p9HFQa18tMmwTk7HqARikjDE_gsSVJAc8Qk8-gt87MbQpk8oQnLBk8sJ-rqGbOhiDK5WffArHX4rjNSUjdpmk9jPm4GjWbnqjdyEkYAvG0DHtPo66Nb6uOUkk7nI33z91OHehW374nLx-o7qqzpBn_4JrZ38AckaqQM</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Calore, Edenilson Eduardo</creator><creator>Cavaliere, Maria José</creator><creator>Perez Calore, Nilda Maria</creator><creator>de Souza Dias, Suzana</creator><creator>Paes dos Santos, Regina</creator><creator>Vilela-de-Almeida, Lis</creator><general>Karger</general><general>S. 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Obstetrics</topic><topic>Humans</topic><topic>Ki-67 Antigen - analysis</topic><topic>Medical sciences</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calore, Edenilson Eduardo</creatorcontrib><creatorcontrib>Cavaliere, Maria José</creatorcontrib><creatorcontrib>Perez Calore, Nilda Maria</creatorcontrib><creatorcontrib>de Souza Dias, Suzana</creatorcontrib><creatorcontrib>Paes dos Santos, Regina</creatorcontrib><creatorcontrib>Vilela-de-Almeida, Lis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic and obstetric investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calore, Edenilson Eduardo</au><au>Cavaliere, Maria José</au><au>Perez Calore, Nilda Maria</au><au>de Souza Dias, Suzana</au><au>Paes dos Santos, Regina</au><au>Vilela-de-Almeida, Lis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Ki-67 in Cervical Epithelial Cells in Preneoplastic Lesions of Patients with AIDS</atitle><jtitle>Gynecologic and obstetric investigation</jtitle><addtitle>Gynecol Obstet Invest</addtitle><date>2001-01</date><risdate>2001</risdate><volume>51</volume><issue>1</issue><spage>51</spage><epage>54</epage><pages>51-54</pages><issn>0378-7346</issn><eissn>1423-002X</eissn><coden>GOBIDS</coden><abstract>The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in women with AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patients and 18 Lo-CIN and 14 Hi-CIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 ± 10.44) as compared with Lo-CIN of general-population women (mean 17.08 ± 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the Hi-CIN of AIDS patients and of patients from the general population (p > 0.05). We conclude that the proliferative potential of cervical cells in Lo-CIN – as studied by the expression of the proliferation marker Ki-67 – is higher in AIDS patients than in the general population.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11150876</pmid><doi>10.1159/000052891</doi><tpages>4</tpages></addata></record> |
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| ispartof | Gynecologic and obstetric investigation, 2001-01, Vol.51 (1), p.51-54 |
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| subjects | Acquired Immunodeficiency Syndrome - complications Adolescent Adult Biological and medical sciences Cell Nucleus - chemistry Cervical Intraepithelial Neoplasia - chemistry Cervical Intraepithelial Neoplasia - complications Cervix Uteri - chemistry Cervix Uteri - ultrastructure Epithelial Cells - chemistry Epithelial Cells - ultrastructure Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Ki-67 Antigen - analysis Medical sciences Original Paper Retrospective Studies Tumors |
| title | Expression of Ki-67 in Cervical Epithelial Cells in Preneoplastic Lesions of Patients with AIDS |
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