A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy
Chemically synthesized hydroxyapatite/poly- l-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implante...
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| Veröffentlicht in: | Biomaterials 2001-03, Vol.22 (6), p.571-575 |
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| creator | Ignjatović, Nenad Savić, Vojin Najman, Stevo Plavšić, Milenko Uskoković, Dragan |
| description | Chemically synthesized hydroxyapatite/poly-
l-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650
cm
−1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760
cm
−1 originating from the CO group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found. |
| doi_str_mv | 10.1016/S0142-9612(00)00215-5 |
| format | Article |
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l-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650
cm
−1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760
cm
−1 originating from the CO group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(00)00215-5</identifier><identifier>PMID: 11219721</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Absorption ; Absorption band ; Animals ; Autologous bone ; Biocompatible Materials ; Biodegradation ; Biological and medical sciences ; Bone ; Bone Substitutes - chemistry ; Ceramic materials ; Collagen ; Composite materials ; Durapatite - chemistry ; Fourier transform infrared spectroscopy ; FT-IR spectroscopy ; Hydroxyapatite/poly- l-lactide composite biomaterial ; Implants (surgical) ; In vivo ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Scanning ; Orthopedic surgery ; Polyesters - chemistry ; Powders ; Scanning electron microscopy ; Spectroscopy, Fourier Transform Infrared ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments</subject><ispartof>Biomaterials, 2001-03, Vol.22 (6), p.571-575</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-c79cd584033b4d5a28722673df36751ee5b94e0e9553bd843f4c59c049f2cd4e3</citedby><cites>FETCH-LOGICAL-c548t-c79cd584033b4d5a28722673df36751ee5b94e0e9553bd843f4c59c049f2cd4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0142-9612(00)00215-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=885469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11219721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ignjatović, Nenad</creatorcontrib><creatorcontrib>Savić, Vojin</creatorcontrib><creatorcontrib>Najman, Stevo</creatorcontrib><creatorcontrib>Plavšić, Milenko</creatorcontrib><creatorcontrib>Uskoković, Dragan</creatorcontrib><title>A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Chemically synthesized hydroxyapatite/poly-
l-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650
cm
−1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760
cm
−1 originating from the CO group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.</description><subject>Absorption</subject><subject>Absorption band</subject><subject>Animals</subject><subject>Autologous bone</subject><subject>Biocompatible Materials</subject><subject>Biodegradation</subject><subject>Biological and medical sciences</subject><subject>Bone</subject><subject>Bone Substitutes - chemistry</subject><subject>Ceramic materials</subject><subject>Collagen</subject><subject>Composite materials</subject><subject>Durapatite - chemistry</subject><subject>Fourier transform infrared spectroscopy</subject><subject>FT-IR spectroscopy</subject><subject>Hydroxyapatite/poly- l-lactide composite biomaterial</subject><subject>Implants (surgical)</subject><subject>In vivo</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microscopy, Electron, Scanning</subject><subject>Orthopedic surgery</subject><subject>Polyesters - chemistry</subject><subject>Powders</subject><subject>Scanning electron microscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ignjatović, Nenad</creatorcontrib><creatorcontrib>Savić, Vojin</creatorcontrib><creatorcontrib>Najman, Stevo</creatorcontrib><creatorcontrib>Plavšić, Milenko</creatorcontrib><creatorcontrib>Uskoković, Dragan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ignjatović, Nenad</au><au>Savić, Vojin</au><au>Najman, Stevo</au><au>Plavšić, Milenko</au><au>Uskoković, Dragan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>22</volume><issue>6</issue><spage>571</spage><epage>575</epage><pages>571-575</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Chemically synthesized hydroxyapatite/poly-
l-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650
cm
−1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760
cm
−1 originating from the CO group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11219721</pmid><doi>10.1016/S0142-9612(00)00215-5</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Absorption Absorption band Animals Autologous bone Biocompatible Materials Biodegradation Biological and medical sciences Bone Bone Substitutes - chemistry Ceramic materials Collagen Composite materials Durapatite - chemistry Fourier transform infrared spectroscopy FT-IR spectroscopy Hydroxyapatite/poly- l-lactide composite biomaterial Implants (surgical) In vivo Medical sciences Mice Mice, Inbred BALB C Microscopy, Electron, Scanning Orthopedic surgery Polyesters - chemistry Powders Scanning electron microscopy Spectroscopy, Fourier Transform Infrared Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments |
| title | A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy |
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