Aquaporin‐4 deficiency in skeletal muscle and brain of dystrophic mdx mice

ABSTRACT We report a detailed study of AQP4 expression in the neuromuscular system of mdx mice. Immunocytochemical analysis performed by double immunostaining revealed that mdx mice manifest a progressive reduction in AQP4 at the sarcolemmal level of skeletal muscle fast fibers and that type IIB fib...

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Veröffentlicht in:	The FASEB journal 2001-01, Vol.15 (1), p.90-98
Hauptverfasser:	FRIGERI, ANTONIO, NICCHIA, GRAZIA PAOLA, NICO, BEATRICE, QUONDAMATTEO, FABIO, HERKEN, RAINER, RONCALI, LUISA, SVELTO, MARIA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AQP4 Aquaporin 4 aquaporins Aquaporins - deficiency Aquaporins - genetics Aquaporins - metabolism Blotting, Western Brain - metabolism Brain - pathology Brain - ultrastructure Female Gastric Mucosa - metabolism Immunohistochemistry Kidney - metabolism mdx mice Mice Mice, Inbred mdx Microscopy, Electron Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Fast-Twitch - pathology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Dystrophies - metabolism Muscular Dystrophies - pathology muscular dystrophy orthogonal arrays of particles Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism water channels
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