Superoxide Dismutase SOD1, Encoded on Chromosome 21, but Not SOD2 Is Overexpressed in Brains of Patients With Down Syndrome

AbstractBackgroundThe antioxidant enzyme Cu/Zn-superoxide dismutase-1 (SOD1) gene is localized to chromosome 21q22.1 and catalyzes the dismutation of superoxide anions to hydrogen peroxide, which may lead to the increased production of active oxygen species in Down Syndrome (DS), trisomy 21. Althoug...

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Veröffentlicht in:	Journal of investigative medicine 2001-01, Vol.49 (1), p.41-46
Hauptverfasser:	Gulesserian, Talin, Seidl, Rainer, Hardmeier, Rosmarie, Cairns, Nigel, Lubec, Gert
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - enzymology Brain - enzymology Case-Control Studies Chromosomes, Human, Pair 21 - genetics Down Syndrome - enzymology Down Syndrome - genetics Female Gene Expression Humans Male Middle Aged Oxidative Stress Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1
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