Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells

A high extracellular calcium level inhibits the formation of osteoclast-like cells and stimulates osteoblastic proliferation, indicating that extracellular calcium plays an important role in the process of bone remodeling. The present study examined the effects of a high extracellular calcium level...

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Veröffentlicht in:	Journal of bone and mineral metabolism 2001, Vol.19 (1), p.13-19
Hauptverfasser:	NAKADE, Osamu, TAKAHASHI, Kanae, TAKUMA, Taishin, AOKI, Takashi, KAKU, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alkaline Phosphatase - metabolism Biological and medical sciences Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - genetics Calcium Calcium (extracellular) Calcium Chloride - pharmacology Cell Differentiation - drug effects Cell Division - drug effects Cells Cells, Cultured Collagen - biosynthesis Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Humans Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin - secretion Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Skeleton and joints Transforming Growth Factor beta Vertebrates: osteoarticular system, musculoskeletal system
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