Association of β-Blocker Dose with Serum Procollagen Concentrations and Cardiac Response to Spironolactone in Patients with Heart Failure

Study Objective. To determine whether β‐blocker dose influences cardiac collagen turnover and the effects of spironolactone on cardiac collagen turnover in patients with heart failure. Design. Prospective clinical study. Setting. Two heart failure centers. Patients. Eighty‐eight spironolactone‐naïve...

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Veröffentlicht in:	Pharmacotherapy 2007-06, Vol.27 (6), p.801-812
Hauptverfasser:	Cavallari, Larisa H., Momary, Kathryn M., Groo, Vicki L., Viana, Marlos A. G., Camp, Joseph R., Stamos, Thomas D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Adult Aged Atenolol - administration & dosage Atenolol - pharmacology Biological and medical sciences Carbazoles - administration & dosage Carbazoles - pharmacology cardiac fibrosis Cardiology. Vascular system Diuretics - administration & dosage Diuretics - pharmacology Dose-Response Relationship, Drug Female Fibrosis - physiopathology Heart heart failure Heart Failure - drug therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Male Medical sciences Metoprolol - administration & dosage Metoprolol - pharmacology Middle Aged Peptide Fragments - blood Peptide Fragments - drug effects Peptide Fragments - metabolism Pharmacology. Drug treatments procollagen Procollagen - blood Procollagen - drug effects Procollagen - metabolism Propanolamines - administration & dosage Propanolamines - pharmacology Prospective Studies Radioimmunoassay spironolactone Spironolactone - administration & dosage Spironolactone - pharmacology β-blocker
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