Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by lipopolysaccharide in vivo

Interleukin (IL)-1 and tumor necrotic factor α (TNFα) are pivotal in the pathogenesis of endotoxemia. In spite of the in vitro finding that IL-1β, but not TNFα, can induce iNOS mRNA and NO production as a single stimulus in hepatocytes in primary culture, the involvement of IL-1 in iNOS induction in...

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Veröffentlicht in:	Nitric oxide 2007-06, Vol.16 (4), p.433-441
Hauptverfasser:	Takagi, Kunio, Matsumura, Shinji, Okuda-Ashitaka, Emiko, Okuda, Kazuyuki, Watanabe, Jun, Takahashi, Hakuo, Iwakura, Yoichiro, Ito, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - metabolism Interleukin-1 Interleukin-1 - pharmacology Knockout mice Kupffer cells Lipopolysaccharide Lipopolysaccharides - pharmacology Liver - drug effects Liver - enzymology Liver - metabolism Mice Mice, Knockout Nitric oxide Nitric Oxide Synthase Type II - drug effects Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism RNA, Messenger - biosynthesis Toll-like receptor 4 Toll-Like Receptor 4 - metabolism Tumor necrosis factor α
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