Suppression of HIV Replication in the Resting CD4+T Cell Reservoir by Autologous CD8+T Cells: Implications for the Development of Therapeutic Strategies

CD8+T cell-mediated antiviral activity against HIV has been described consistently in infected individuals; however, the role of this activity in controlling replication of HIV in the latently infected, resting CD4+T cell reservoir is unclear. By using an ex vivo system, we show that replication of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-01, Vol.98 (1), p.253-258
Hauptverfasser:	Chun, Tae-Wook, Justement, J. Shawn, Moir, Susan, Hallahan, Claire W., Ehler, Linda A., Liu, Shuying, McLaughlin, Mary, Dybul, Mark, Mican, JoAnn M., Fauci, Anthony S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Antibodies Antiretroviral Therapy, Highly Active Antiretrovirals Antivirals Biological Sciences CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation CD8-Positive T-Lymphocytes - virology Cells Cells, Cultured Chemokine CCL4 Chemokine CCL5 - analysis Chronic Disease Coculture Techniques Cultured cells Disease Disease Progression Flow Cytometry Highly active antiretroviral therapy HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - immunology HIV Infections - therapy HIV Infections - virology HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus Humans Immunology Macrophage Inflammatory Proteins - analysis Phenotype T lymphocytes Viremia Virus Latency Virus Replication Viruses
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