Derivatives of Iressa, a Specific Epidermal Growth Factor Receptor Inhibitor, are Powerful Apoptosis Inducers in PC3 Prostatic Cancer Cells

The tyrosine kinase activity of the epidermal growth factor receptor (EGFR) is widely involved in signaling pathways and often deregulated in cancer. Its role in the development of prostate cancer is well established, and therapeutic strategies such as blockade of the intracellular tyrosine kinase d...

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Veröffentlicht in:	ChemMedChem 2007-03, Vol.2 (3), p.318-332
Hauptverfasser:	Telliez, Aurélie, Desroses, Matthieu, Pommery, Nicole, Briand, Olivier, Farce, Amaury, Laconde, Guillaume, Lemoine, Amélie, Depreux, Patrick, Hénichart, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology antitumor agents Apoptosis - drug effects Apoptosis - physiology biological activity Cell Line, Tumor EGFR Humans Male prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Quinazolines - chemical synthesis Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism tyrosine kinase inhibitors
Online-Zugang:	Volltext
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