Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved?
The mechanism of pathogenesis of hypertension in patients with obstructive sleep apnea (OSA) is unknown. Many investigators point to the high sympathetic nervous system activity (SNS) observed in OSA patients. However, there is no clear explanation as to the mechanism for the development of SNS hype...
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| Veröffentlicht in: | Medical hypotheses 2001-01, Vol.56 (1), p.17-19 |
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| creator | Loredo, J.S. Clausen, J.L. Nelesen, R.A. Ancoli-Israel, S. Ziegler, M.G. Dimsdale, J.E. |
| description | The mechanism of pathogenesis of hypertension in patients with obstructive sleep apnea (OSA) is unknown. Many investigators point to the high sympathetic nervous system activity (SNS) observed in OSA patients. However, there is no clear explanation as to the mechanism for the development of SNS hyperactivity in these patients. A common feature of patients with OSA is repetitive bouts of transient hypoxemia during sleep. Repetitive transient hypoxemia in rats has resulted in hypertension. In OSA patients, resolution of nocturnal hypoxemia with CPAP has corrected nocturnal and diurnal hypertension. Also, exposure to hyperoxia reduces blood pressure and sympathetic activity in OSA patients, but not in normals. These data suggest a significant role of peripheral chemoreceptors in the regulation of vascular tone. We hypothesize that peripheral chemoreceptors significantly contribute to the pathogenesis of hypertension in patients with OSA and that this is associated with chemoreceptor hyperactivity. This implies that correcting the intermittent nocturnal hypoxemia alone may prevent the cardiovascular morbidity associated with obstructive sleep apnea. |
| doi_str_mv | 10.1054/mehy.2000.1086 |
| format | Article |
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Many investigators point to the high sympathetic nervous system activity (SNS) observed in OSA patients. However, there is no clear explanation as to the mechanism for the development of SNS hyperactivity in these patients. A common feature of patients with OSA is repetitive bouts of transient hypoxemia during sleep. Repetitive transient hypoxemia in rats has resulted in hypertension. In OSA patients, resolution of nocturnal hypoxemia with CPAP has corrected nocturnal and diurnal hypertension. Also, exposure to hyperoxia reduces blood pressure and sympathetic activity in OSA patients, but not in normals. These data suggest a significant role of peripheral chemoreceptors in the regulation of vascular tone. We hypothesize that peripheral chemoreceptors significantly contribute to the pathogenesis of hypertension in patients with OSA and that this is associated with chemoreceptor hyperactivity. 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Etiology ; Humans ; Hypertension - physiopathology ; Hypoxia - blood ; Medical sciences ; Rats ; Sleep Apnea Syndromes - blood ; Sleep Apnea Syndromes - physiopathology</subject><ispartof>Medical hypotheses, 2001-01, Vol.56 (1), p.17-19</ispartof><rights>2001 Harcourt Publishers Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-9debb554d7c1194534a7ba0cb0abfed589f22b0cd1516e54dbe9d971ce81218a3</citedby><cites>FETCH-LOGICAL-c369t-9debb554d7c1194534a7ba0cb0abfed589f22b0cd1516e54dbe9d971ce81218a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1054/mehy.2000.1086$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,4012,27910,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1062828$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11133249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loredo, J.S.</creatorcontrib><creatorcontrib>Clausen, J.L.</creatorcontrib><creatorcontrib>Nelesen, R.A.</creatorcontrib><creatorcontrib>Ancoli-Israel, S.</creatorcontrib><creatorcontrib>Ziegler, M.G.</creatorcontrib><creatorcontrib>Dimsdale, J.E.</creatorcontrib><title>Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved?</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>The mechanism of pathogenesis of hypertension in patients with obstructive sleep apnea (OSA) is unknown. Many investigators point to the high sympathetic nervous system activity (SNS) observed in OSA patients. However, there is no clear explanation as to the mechanism for the development of SNS hyperactivity in these patients. A common feature of patients with OSA is repetitive bouts of transient hypoxemia during sleep. Repetitive transient hypoxemia in rats has resulted in hypertension. In OSA patients, resolution of nocturnal hypoxemia with CPAP has corrected nocturnal and diurnal hypertension. Also, exposure to hyperoxia reduces blood pressure and sympathetic activity in OSA patients, but not in normals. These data suggest a significant role of peripheral chemoreceptors in the regulation of vascular tone. We hypothesize that peripheral chemoreceptors significantly contribute to the pathogenesis of hypertension in patients with OSA and that this is associated with chemoreceptor hyperactivity. This implies that correcting the intermittent nocturnal hypoxemia alone may prevent the cardiovascular morbidity associated with obstructive sleep apnea.</description><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Hypoxia - blood</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Sleep Apnea Syndromes - blood</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAURoMoOo5uXUoX4q5jkj6SuBEZfMHAIOg65HFLI32ZdArz722Zgm5cXT4497uXg9AVwSuCs_SuhnK_ohhPkedHaEGyhMaUMXaMFjjBeSw4Y2foPISvkRJpwk_RGSEkSWgqFuh9q0Pvd6Z3A0ShAugi1TWgItXYqNx34Htogmub-0h5iMbsuhK8qiJTQt16MND1rQ-Ra4a2GsA-XKCTQlUBLue5RJ_PTx_r13izfXlbP25ik-Sij4UFrbMstcwQItIsSRXTChuNlS7AZlwUlGpsLMlIDiOnQVjBiAFOKOEqWaLbQ2_n2-8dhF7WLhioKtVAuwuS4YylPOUjuDqAxrcheChk512t_F4SLCeJcpIoJ4lykjguXM_NO12D_cVnayNwMwMqGFUVXjXGhT-1OeV0OswPGIwaBgdeBuOgMWDd6K2XtnX_vfADDi2PKw</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Loredo, J.S.</creator><creator>Clausen, J.L.</creator><creator>Nelesen, R.A.</creator><creator>Ancoli-Israel, S.</creator><creator>Ziegler, M.G.</creator><creator>Dimsdale, J.E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200101</creationdate><title>Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved?</title><author>Loredo, J.S. ; Clausen, J.L. ; Nelesen, R.A. ; Ancoli-Israel, S. ; Ziegler, M.G. ; Dimsdale, J.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-9debb554d7c1194534a7ba0cb0abfed589f22b0cd1516e54dbe9d971ce81218a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Hypoxia - blood</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Sleep Apnea Syndromes - blood</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loredo, J.S.</creatorcontrib><creatorcontrib>Clausen, J.L.</creatorcontrib><creatorcontrib>Nelesen, R.A.</creatorcontrib><creatorcontrib>Ancoli-Israel, S.</creatorcontrib><creatorcontrib>Ziegler, M.G.</creatorcontrib><creatorcontrib>Dimsdale, J.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loredo, J.S.</au><au>Clausen, J.L.</au><au>Nelesen, R.A.</au><au>Ancoli-Israel, S.</au><au>Ziegler, M.G.</au><au>Dimsdale, J.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved?</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2001-01</date><risdate>2001</risdate><volume>56</volume><issue>1</issue><spage>17</spage><epage>19</epage><pages>17-19</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>The mechanism of pathogenesis of hypertension in patients with obstructive sleep apnea (OSA) is unknown. Many investigators point to the high sympathetic nervous system activity (SNS) observed in OSA patients. However, there is no clear explanation as to the mechanism for the development of SNS hyperactivity in these patients. A common feature of patients with OSA is repetitive bouts of transient hypoxemia during sleep. Repetitive transient hypoxemia in rats has resulted in hypertension. In OSA patients, resolution of nocturnal hypoxemia with CPAP has corrected nocturnal and diurnal hypertension. Also, exposure to hyperoxia reduces blood pressure and sympathetic activity in OSA patients, but not in normals. These data suggest a significant role of peripheral chemoreceptors in the regulation of vascular tone. We hypothesize that peripheral chemoreceptors significantly contribute to the pathogenesis of hypertension in patients with OSA and that this is associated with chemoreceptor hyperactivity. 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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chemoreceptor Cells - physiology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Humans Hypertension - physiopathology Hypoxia - blood Medical sciences Rats Sleep Apnea Syndromes - blood Sleep Apnea Syndromes - physiopathology |
| title | Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved? |
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