Lectin-like oxidized-LDL receptor-1 (LOX-1) polymorphisms influence cardiovascular events rate during statin treatment

Abstract Background Oxidized-LDL (ox-LDL) are involved in atherothrombosis by induction of endothelial dysfunction and thrombosis. The specific receptor lectin-like oxidized-LDL receptor-1 (LOX-1) is expressed in endothelial cells, monocytes and platelets. LOX-1 gene allelic variants (3′UTR/T) have...

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Veröffentlicht in:	International journal of cardiology 2007-06, Vol.119 (1), p.41-47
Hauptverfasser:	Puccetti, L, Pasqui, A.L, Bruni, F, Pastorelli, M, Ciani, F, Palazzuoli, A, Pontani, A, Ghezzi, A, Auteri, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticholesteremic Agents - administration & dosage Atorvastatin Calcium Biological and medical sciences C-Reactive Protein - metabolism Cardiology. Vascular system Cardiovascular Cardiovascular events Cholesterol, LDL - blood Coronary Artery Disease - drug therapy Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Drug Resistance - genetics Female Heptanoic Acids - administration & dosage Heterozygote Humans Hypercholesterolemia - drug therapy Hypercholesterolemia - epidemiology Hypercholesterolemia - genetics LOX-1 Male Medical sciences Middle Aged Oxidized-LDL Platelets Polymorphism, Genetic Pyrroles - administration & dosage Retrospective Studies Risk Factors Scavenger Receptors, Class E - genetics Simvastatin - administration & dosage Statins Thrombosis - drug therapy Thrombosis - epidemiology Thrombosis - genetics
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