Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast
Aims: To evaluate the expression of androgen receptors (AR) and two androgen‐induced proteins [apolipoprotein D (ApoD) and pepsinogen C (PepC)] in ductal carcinoma in situ (DCIS) of the breast. Methods and results: AR, ApoD and PepC expression was examined in 28 cases of pure DCIS and in 31 cases...
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| Veröffentlicht in: | Histopathology 2007-06, Vol.50 (7), p.866-874 |
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| creator | Gonzalez, L O Corte, M D Junquera, S Bongera, M Rodriguez, J C Vizoso, F J |
| description | Aims: To evaluate the expression of androgen receptors (AR) and two androgen‐induced proteins [apolipoprotein D (ApoD) and pepsinogen C (PepC)] in ductal carcinoma in situ (DCIS) of the breast.
Methods and results: AR, ApoD and PepC expression was examined in 28 cases of pure DCIS and in 31 cases of DCIS adjacent to invasive carcinoma of the breast using immunohistochemical methods and then correlated with the architectural subtype, the degree of differentiation and the ostrogen receptor (ER)/progesterone receptor (PgR)/HER‐2 status. We found no significant differences between pure DCIS and DCIS adjacent to invasive breast cancer regarding the percentage of positive cases for ApoD (64.3% versus 54.8%), PepC (42.9% versus 48.4%), ER (64.3% versus 58.1%), PgR (60.7% versus 58.1%) and HER‐2 (39.3% versus 67.7%). However, there was a significantly higher percentage of AR+ DCIS among those adjacent to invasive carcinomas of the breast than among pure DCIS lesions (93.5% versus 60.9%) (P = 0.009). AR expression did not correlate with architectural subtype, degree of differentiation, or ER/PgR/HER‐2/ApoD/PepC status, in cases of pure DCIS, nor in DCIS adjacent to invasive carcinoma of the breast.
Conclusions: AR expression may represent an independent predictive factor in DCIS of the breast. |
| doi_str_mv | 10.1111/j.1365-2559.2007.02687.x |
| format | Article |
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Methods and results: AR, ApoD and PepC expression was examined in 28 cases of pure DCIS and in 31 cases of DCIS adjacent to invasive carcinoma of the breast using immunohistochemical methods and then correlated with the architectural subtype, the degree of differentiation and the ostrogen receptor (ER)/progesterone receptor (PgR)/HER‐2 status. We found no significant differences between pure DCIS and DCIS adjacent to invasive breast cancer regarding the percentage of positive cases for ApoD (64.3% versus 54.8%), PepC (42.9% versus 48.4%), ER (64.3% versus 58.1%), PgR (60.7% versus 58.1%) and HER‐2 (39.3% versus 67.7%). However, there was a significantly higher percentage of AR+ DCIS among those adjacent to invasive carcinomas of the breast than among pure DCIS lesions (93.5% versus 60.9%) (P = 0.009). AR expression did not correlate with architectural subtype, degree of differentiation, or ER/PgR/HER‐2/ApoD/PepC status, in cases of pure DCIS, nor in DCIS adjacent to invasive carcinoma of the breast.
Conclusions: AR expression may represent an independent predictive factor in DCIS of the breast.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2007.02687.x</identifier><identifier>PMID: 17543076</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>androgen receptor ; apolipoprotein D ; Apolipoproteins D - metabolism ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Intraductal, Noninfiltrating - metabolism ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Female ; Glycoproteins - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Mammary gland diseases ; Medical sciences ; Membrane Transport Proteins - metabolism ; Middle Aged ; Neoplasm Proteins - metabolism ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; pepsinogen C ; Pepsinogen C - metabolism ; Receptor, ErbB-2 - metabolism ; Receptors, Androgen - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Tumors</subject><ispartof>Histopathology, 2007-06, Vol.50 (7), p.866-874</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4357-ebc0362ec605632a4c7b3da404726d689e9cbd6b309d08f778093a279e82ec623</citedby><cites>FETCH-LOGICAL-c4357-ebc0362ec605632a4c7b3da404726d689e9cbd6b309d08f778093a279e82ec623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.2007.02687.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.2007.02687.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18799988$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17543076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez, L O</creatorcontrib><creatorcontrib>Corte, M D</creatorcontrib><creatorcontrib>Junquera, S</creatorcontrib><creatorcontrib>Bongera, M</creatorcontrib><creatorcontrib>Rodriguez, J C</creatorcontrib><creatorcontrib>Vizoso, F J</creatorcontrib><title>Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims: To evaluate the expression of androgen receptors (AR) and two androgen‐induced proteins [apolipoprotein D (ApoD) and pepsinogen C (PepC)] in ductal carcinoma in situ (DCIS) of the breast.
Methods and results: AR, ApoD and PepC expression was examined in 28 cases of pure DCIS and in 31 cases of DCIS adjacent to invasive carcinoma of the breast using immunohistochemical methods and then correlated with the architectural subtype, the degree of differentiation and the ostrogen receptor (ER)/progesterone receptor (PgR)/HER‐2 status. We found no significant differences between pure DCIS and DCIS adjacent to invasive breast cancer regarding the percentage of positive cases for ApoD (64.3% versus 54.8%), PepC (42.9% versus 48.4%), ER (64.3% versus 58.1%), PgR (60.7% versus 58.1%) and HER‐2 (39.3% versus 67.7%). However, there was a significantly higher percentage of AR+ DCIS among those adjacent to invasive carcinomas of the breast than among pure DCIS lesions (93.5% versus 60.9%) (P = 0.009). AR expression did not correlate with architectural subtype, degree of differentiation, or ER/PgR/HER‐2/ApoD/PepC status, in cases of pure DCIS, nor in DCIS adjacent to invasive carcinoma of the breast.
Conclusions: AR expression may represent an independent predictive factor in DCIS of the breast.</description><subject>androgen receptor</subject><subject>apolipoprotein D</subject><subject>Apolipoproteins D - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - metabolism</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Female</subject><subject>Glycoproteins - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>pepsinogen C</subject><subject>Pepsinogen C - metabolism</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Androgen - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi0EotvCKyBfQHBImNiJnRw4VEu7W6kqSPw7Wo4zC16ycbATdfsUvDLObrS94otH33y_mdEMITSDNIvv_TbNuCgSVhRVygBkCkyUMt0_IYtT4ilZAIcqgUzIM3IewhYgk5yx5-Qsk0XOQYoF-Xu17z2GYF1H3YbqrvHuJ3bUo8F-cH5S6HDvTpnEds1osKG9dwPaLtC3unet7d0s0I8Hpsc-2O5Qa_mORjlSg26p0d5EfacnLdhhnNoOv5DWHnUYXpBnG90GfDn_F-Tb9dXX5Tq5_bS6WV7eJibnhUywNsAFQyOgEJzp3MiaNzqHXDLRiLLCytSNqOMCGig3UpZQcc1kheUEMX5B3hzrxqn_jBgGtbPBYNvqDt0YlIRC5jmIaCyPRuNdCB43qvd2p_2DykBNx1BbNe1cTTtX0zHU4RhqH9FXc4-x3mHzCM7bj4bXs0EHo9uN152x4dFXyqqqyjL6Phx997bFh_8eQK1vvkxR5JMjb8OA-xOv_W8lJJeF-nG3UktYrT_fxeA7_wcWarZI</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Gonzalez, L O</creator><creator>Corte, M D</creator><creator>Junquera, S</creator><creator>Bongera, M</creator><creator>Rodriguez, J C</creator><creator>Vizoso, F J</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast</title><author>Gonzalez, L O ; Corte, M D ; Junquera, S ; Bongera, M ; Rodriguez, J C ; Vizoso, F J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4357-ebc0362ec605632a4c7b3da404726d689e9cbd6b309d08f778093a279e82ec623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>androgen receptor</topic><topic>apolipoprotein D</topic><topic>Apolipoproteins D - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - metabolism</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Female</topic><topic>Glycoproteins - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>pepsinogen C</topic><topic>Pepsinogen C - metabolism</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Androgen - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez, L O</creatorcontrib><creatorcontrib>Corte, M D</creatorcontrib><creatorcontrib>Junquera, S</creatorcontrib><creatorcontrib>Bongera, M</creatorcontrib><creatorcontrib>Rodriguez, J C</creatorcontrib><creatorcontrib>Vizoso, F J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez, L O</au><au>Corte, M D</au><au>Junquera, S</au><au>Bongera, M</au><au>Rodriguez, J C</au><au>Vizoso, F J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2007-06</date><risdate>2007</risdate><volume>50</volume><issue>7</issue><spage>866</spage><epage>874</epage><pages>866-874</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims: To evaluate the expression of androgen receptors (AR) and two androgen‐induced proteins [apolipoprotein D (ApoD) and pepsinogen C (PepC)] in ductal carcinoma in situ (DCIS) of the breast.
Methods and results: AR, ApoD and PepC expression was examined in 28 cases of pure DCIS and in 31 cases of DCIS adjacent to invasive carcinoma of the breast using immunohistochemical methods and then correlated with the architectural subtype, the degree of differentiation and the ostrogen receptor (ER)/progesterone receptor (PgR)/HER‐2 status. We found no significant differences between pure DCIS and DCIS adjacent to invasive breast cancer regarding the percentage of positive cases for ApoD (64.3% versus 54.8%), PepC (42.9% versus 48.4%), ER (64.3% versus 58.1%), PgR (60.7% versus 58.1%) and HER‐2 (39.3% versus 67.7%). However, there was a significantly higher percentage of AR+ DCIS among those adjacent to invasive carcinomas of the breast than among pure DCIS lesions (93.5% versus 60.9%) (P = 0.009). AR expression did not correlate with architectural subtype, degree of differentiation, or ER/PgR/HER‐2/ApoD/PepC status, in cases of pure DCIS, nor in DCIS adjacent to invasive carcinoma of the breast.
Conclusions: AR expression may represent an independent predictive factor in DCIS of the breast.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17543076</pmid><doi>10.1111/j.1365-2559.2007.02687.x</doi><tpages>9</tpages></addata></record> |
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| subjects | androgen receptor apolipoprotein D Apolipoproteins D - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Female Glycoproteins - metabolism Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Mammary gland diseases Medical sciences Membrane Transport Proteins - metabolism Middle Aged Neoplasm Proteins - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques pepsinogen C Pepsinogen C - metabolism Receptor, ErbB-2 - metabolism Receptors, Androgen - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Tumors |
| title | Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast |
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