A Peltier thermal cycling unit for radiopharmaceutical synthesis
We have investigated the use of Peltier devices to rapidly cycle the temperature of reaction vessels in a radiopharmaceutical synthesis system. Peltier devices have the advantage that they can be actively cooled as well as heated, allowing precise and rapid control of vessel temperatures. Reaction v...
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| Veröffentlicht in: | Applied radiation and isotopes 2001-01, Vol.54 (1), p.97-100 |
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| container_title | Applied radiation and isotopes |
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| creator | McKinney, C.J. Nader, M.W. |
| description | We have investigated the use of Peltier devices to rapidly cycle the temperature of reaction vessels in a radiopharmaceutical synthesis system. Peltier devices have the advantage that they can be actively cooled as well as heated, allowing precise and rapid control of vessel temperatures. Reaction vessel temperatures of between −6°C and 110°C have been obtained with commercially available devices with reasonable cycle times. Two devices have been used as the basis for a general purpose, two-pot synthesis system for production of [
11C] compounds such as raclopride. |
| doi_str_mv | 10.1016/S0969-8043(00)00189-5 |
| format | Article |
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11C] compounds such as raclopride.</description><subject>Automation - instrumentation</subject><subject>Automation - methods</subject><subject>Carbon Dioxide</subject><subject>Carbon Radioisotopes</subject><subject>Cooler</subject><subject>Equipment Design</subject><subject>Heater</subject><subject>Nuclear Medicine - instrumentation</subject><subject>Nuclear Medicine - methods</subject><subject>Raclopride - chemical synthesis</subject><subject>Radiochemistry</subject><subject>Radiopharmaceuticals - chemical synthesis</subject><subject>TEC</subject><subject>Thermoelectric</subject><subject>Tomography, Emission-Computed</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7vr4CUpPoofqJGna5KSy-IIFBfUc0nTqRrrtmrTC_nuzD_ToaWDmm9dHyAmFSwo0v3oFlatUQsbPAS4AqFSp2CFjKguWKgmwS8a_yIgchPAJAJlUbJ-MKKVZxoQak5vb5AWb3qFP-hn6uWkSu7SNaz-SoXV9Unc-8aZy3WJmYtXi0DsbobBsIx9cOCJ7tWkCHm_jIXm_v3ubPKbT54enye00tTynfWpUzspCqoKjKGvJSl7mkNOSm0raDBVyLgWFPCYKZMiUNfHW2kgmckkF54fkbDN34buvAUOv5y5YbBrTYjcEXYAoMhAsgmIDWt-F4LHWC-_mxi81Bb1Sp9fq9MqLBtBrdVrEvtPtgqGcY_XXtXUVgesNgPHN72hMB-uwtVg5j7bXVef-WfEDKkJ9bQ</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>McKinney, C.J.</creator><creator>Nader, M.W.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>A Peltier thermal cycling unit for radiopharmaceutical synthesis</title><author>McKinney, C.J. ; Nader, M.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-a962b78973e5bf82b3b6061b3ad8c4e9e3385106b3a7e2e29ca489fa825681533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Automation - instrumentation</topic><topic>Automation - methods</topic><topic>Carbon Dioxide</topic><topic>Carbon Radioisotopes</topic><topic>Cooler</topic><topic>Equipment Design</topic><topic>Heater</topic><topic>Nuclear Medicine - instrumentation</topic><topic>Nuclear Medicine - methods</topic><topic>Raclopride - chemical synthesis</topic><topic>Radiochemistry</topic><topic>Radiopharmaceuticals - chemical synthesis</topic><topic>TEC</topic><topic>Thermoelectric</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKinney, C.J.</creatorcontrib><creatorcontrib>Nader, M.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKinney, C.J.</au><au>Nader, M.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Peltier thermal cycling unit for radiopharmaceutical synthesis</atitle><jtitle>Applied radiation and isotopes</jtitle><addtitle>Appl Radiat Isot</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>54</volume><issue>1</issue><spage>97</spage><epage>100</epage><pages>97-100</pages><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>We have investigated the use of Peltier devices to rapidly cycle the temperature of reaction vessels in a radiopharmaceutical synthesis system. Peltier devices have the advantage that they can be actively cooled as well as heated, allowing precise and rapid control of vessel temperatures. Reaction vessel temperatures of between −6°C and 110°C have been obtained with commercially available devices with reasonable cycle times. Two devices have been used as the basis for a general purpose, two-pot synthesis system for production of [
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| ispartof | Applied radiation and isotopes, 2001-01, Vol.54 (1), p.97-100 |
| issn | 0969-8043 1872-9800 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Automation - instrumentation Automation - methods Carbon Dioxide Carbon Radioisotopes Cooler Equipment Design Heater Nuclear Medicine - instrumentation Nuclear Medicine - methods Raclopride - chemical synthesis Radiochemistry Radiopharmaceuticals - chemical synthesis TEC Thermoelectric Tomography, Emission-Computed |
| title | A Peltier thermal cycling unit for radiopharmaceutical synthesis |
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