Bisphosphonate therapy in fibrous dysplasia
Fibrous dysplasia is proliferation of fibrous tissue within the bone marrow causing osteolytic lesions and pathologic fractures. Recently, second generation bisphosphonates have shown promise in the treatment of patients with fibrous dysplasia. In the current study, six patients with fibrous dysplas...
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| Veröffentlicht in: | Clinical orthopaedics and related research 2001, Vol.382 (382), p.6-12 |
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| container_title | Clinical orthopaedics and related research |
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| creator | LANE, Joseph M KHAN, Safdar N O'CONNOR, William J NYDICK, Martin HOMMEN, Jan Pieter SCHNEIDER, Robert TOMIN, Emre BRAND, Jordan CURTIN, Janet |
| description | Fibrous dysplasia is proliferation of fibrous tissue within the bone marrow causing osteolytic lesions and pathologic fractures. Recently, second generation bisphosphonates have shown promise in the treatment of patients with fibrous dysplasia. In the current study, six patients with fibrous dysplasia were treated with either oral alone or oral and intravenous bisphosphonates. The participants were observed for changes in N-telopeptide, pain score, and radiographic changes. In the current study, the combination bisphosphonate therapy diminished pain, prevented fractures, lowered N-telopeptide values, and led to partial resolution of fibrous dysplasia lesions. |
| doi_str_mv | 10.1097/00003086-200101000-00003 |
| format | Article |
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Recently, second generation bisphosphonates have shown promise in the treatment of patients with fibrous dysplasia. In the current study, six patients with fibrous dysplasia were treated with either oral alone or oral and intravenous bisphosphonates. The participants were observed for changes in N-telopeptide, pain score, and radiographic changes. In the current study, the combination bisphosphonate therapy diminished pain, prevented fractures, lowered N-telopeptide values, and led to partial resolution of fibrous dysplasia lesions.</description><identifier>ISSN: 0009-921X</identifier><identifier>EISSN: 1528-1132</identifier><identifier>DOI: 10.1097/00003086-200101000-00003</identifier><identifier>PMID: 11154006</identifier><identifier>CODEN: CORTBR</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Administration, Oral ; Adult ; Aged ; Alendronate - administration & dosage ; Alendronate - therapeutic use ; Biological and medical sciences ; Biomarkers - urine ; Bone and Bones - drug effects ; Bones, joints and connective tissue. Antiinflammatory agents ; Collagen - urine ; Collagen Type I ; Diphosphonates - administration & dosage ; Diphosphonates - therapeutic use ; Female ; Fibrous Dysplasia of Bone - diagnostic imaging ; Fibrous Dysplasia of Bone - drug therapy ; Follow-Up Studies ; Fractures, Spontaneous - prevention & control ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Middle Aged ; Osteogenesis - drug effects ; Osteolysis - prevention & control ; Pain Measurement ; Pamidronate ; Peptides - urine ; Pharmacology. Drug treatments ; Radiography ; Statistics, Nonparametric</subject><ispartof>Clinical orthopaedics and related research, 2001, Vol.382 (382), p.6-12</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-886c6ac7c39a391c7c50f0195e23ba1d72e2dc30fa8464a34b91eab65e4376093</citedby><cites>FETCH-LOGICAL-c405t-886c6ac7c39a391c7c50f0195e23ba1d72e2dc30fa8464a34b91eab65e4376093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4036,4037,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=861722$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11154006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANE, Joseph M</creatorcontrib><creatorcontrib>KHAN, Safdar N</creatorcontrib><creatorcontrib>O'CONNOR, William J</creatorcontrib><creatorcontrib>NYDICK, Martin</creatorcontrib><creatorcontrib>HOMMEN, Jan Pieter</creatorcontrib><creatorcontrib>SCHNEIDER, Robert</creatorcontrib><creatorcontrib>TOMIN, Emre</creatorcontrib><creatorcontrib>BRAND, Jordan</creatorcontrib><creatorcontrib>CURTIN, Janet</creatorcontrib><title>Bisphosphonate therapy in fibrous dysplasia</title><title>Clinical orthopaedics and related research</title><addtitle>Clin Orthop Relat Res</addtitle><description>Fibrous dysplasia is proliferation of fibrous tissue within the bone marrow causing osteolytic lesions and pathologic fractures. Recently, second generation bisphosphonates have shown promise in the treatment of patients with fibrous dysplasia. In the current study, six patients with fibrous dysplasia were treated with either oral alone or oral and intravenous bisphosphonates. The participants were observed for changes in N-telopeptide, pain score, and radiographic changes. In the current study, the combination bisphosphonate therapy diminished pain, prevented fractures, lowered N-telopeptide values, and led to partial resolution of fibrous dysplasia lesions.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Alendronate - administration & dosage</subject><subject>Alendronate - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - urine</subject><subject>Bone and Bones - drug effects</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Collagen - urine</subject><subject>Collagen Type I</subject><subject>Diphosphonates - administration & dosage</subject><subject>Diphosphonates - therapeutic use</subject><subject>Female</subject><subject>Fibrous Dysplasia of Bone - diagnostic imaging</subject><subject>Fibrous Dysplasia of Bone - drug therapy</subject><subject>Follow-Up Studies</subject><subject>Fractures, Spontaneous - prevention & control</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteogenesis - drug effects</subject><subject>Osteolysis - prevention & control</subject><subject>Pain Measurement</subject><subject>Pamidronate</subject><subject>Peptides - urine</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiography</subject><subject>Statistics, Nonparametric</subject><issn>0009-921X</issn><issn>1528-1132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK3-BQkIXiQ6s1_JHrX4BQUvCt7CZLOhkTSJu-2h_96tjXWGYYaXZ2aXl7EE4RbBZHcQQ0CuUw6AMQHSX-mITVHxPEUU_JhNo2RSw_Fzws5C-NoRUvFTNkFEJQH0lN08NGFY9rvqaO2S9dJ5GrZJ0yV1U_p-E5JqG4aWQkPn7KSmNriLsc_Yx9Pj-_wlXbw9v87vF6mVoNZpnmuryWZWGBIG46CgBjTKcVESVhl3vLICasqlliRkadBRqZWTItNgxIxd7-8Ovv_euLAuVk2wrm2pc_FDRQYqEwJkBPM9aH0fgnd1MfhmRX5bIBQ7o4o_o4qDUXsprl6Ob2zKlav-F0dnInA1AhQstbWnzjbhwOUaM87FD4GHbm8</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>LANE, Joseph M</creator><creator>KHAN, Safdar N</creator><creator>O'CONNOR, William J</creator><creator>NYDICK, Martin</creator><creator>HOMMEN, Jan Pieter</creator><creator>SCHNEIDER, Robert</creator><creator>TOMIN, Emre</creator><creator>BRAND, Jordan</creator><creator>CURTIN, Janet</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Bisphosphonate therapy in fibrous dysplasia</title><author>LANE, Joseph M ; KHAN, Safdar N ; O'CONNOR, William J ; NYDICK, Martin ; HOMMEN, Jan Pieter ; SCHNEIDER, Robert ; TOMIN, Emre ; BRAND, Jordan ; CURTIN, Janet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-886c6ac7c39a391c7c50f0195e23ba1d72e2dc30fa8464a34b91eab65e4376093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Alendronate - administration & dosage</topic><topic>Alendronate - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - urine</topic><topic>Bone and Bones - drug effects</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Collagen - urine</topic><topic>Collagen Type I</topic><topic>Diphosphonates - administration & dosage</topic><topic>Diphosphonates - therapeutic use</topic><topic>Female</topic><topic>Fibrous Dysplasia of Bone - diagnostic imaging</topic><topic>Fibrous Dysplasia of Bone - drug therapy</topic><topic>Follow-Up Studies</topic><topic>Fractures, Spontaneous - prevention & control</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteogenesis - drug effects</topic><topic>Osteolysis - prevention & control</topic><topic>Pain Measurement</topic><topic>Pamidronate</topic><topic>Peptides - urine</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiography</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANE, Joseph M</creatorcontrib><creatorcontrib>KHAN, Safdar N</creatorcontrib><creatorcontrib>O'CONNOR, William J</creatorcontrib><creatorcontrib>NYDICK, Martin</creatorcontrib><creatorcontrib>HOMMEN, Jan Pieter</creatorcontrib><creatorcontrib>SCHNEIDER, Robert</creatorcontrib><creatorcontrib>TOMIN, Emre</creatorcontrib><creatorcontrib>BRAND, Jordan</creatorcontrib><creatorcontrib>CURTIN, Janet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical orthopaedics and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANE, Joseph M</au><au>KHAN, Safdar N</au><au>O'CONNOR, William J</au><au>NYDICK, Martin</au><au>HOMMEN, Jan Pieter</au><au>SCHNEIDER, Robert</au><au>TOMIN, Emre</au><au>BRAND, Jordan</au><au>CURTIN, Janet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bisphosphonate therapy in fibrous dysplasia</atitle><jtitle>Clinical orthopaedics and related research</jtitle><addtitle>Clin Orthop Relat Res</addtitle><date>2001</date><risdate>2001</risdate><volume>382</volume><issue>382</issue><spage>6</spage><epage>12</epage><pages>6-12</pages><issn>0009-921X</issn><eissn>1528-1132</eissn><coden>CORTBR</coden><abstract>Fibrous dysplasia is proliferation of fibrous tissue within the bone marrow causing osteolytic lesions and pathologic fractures. Recently, second generation bisphosphonates have shown promise in the treatment of patients with fibrous dysplasia. In the current study, six patients with fibrous dysplasia were treated with either oral alone or oral and intravenous bisphosphonates. The participants were observed for changes in N-telopeptide, pain score, and radiographic changes. In the current study, the combination bisphosphonate therapy diminished pain, prevented fractures, lowered N-telopeptide values, and led to partial resolution of fibrous dysplasia lesions.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>11154006</pmid><doi>10.1097/00003086-200101000-00003</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Oral Adult Aged Alendronate - administration & dosage Alendronate - therapeutic use Biological and medical sciences Biomarkers - urine Bone and Bones - drug effects Bones, joints and connective tissue. Antiinflammatory agents Collagen - urine Collagen Type I Diphosphonates - administration & dosage Diphosphonates - therapeutic use Female Fibrous Dysplasia of Bone - diagnostic imaging Fibrous Dysplasia of Bone - drug therapy Follow-Up Studies Fractures, Spontaneous - prevention & control Humans Injections, Intravenous Male Medical sciences Middle Aged Osteogenesis - drug effects Osteolysis - prevention & control Pain Measurement Pamidronate Peptides - urine Pharmacology. Drug treatments Radiography Statistics, Nonparametric |
| title | Bisphosphonate therapy in fibrous dysplasia |
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