Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2

Mutations in the BRCA1 or BRCA2 genes predispose to a wide spectrum of familial cancers. The functions of the proteins encoded by BRCA1 and BRCA2 remain to be elucidated, but their interaction and colocalization with hRAD51 suggest a role in homologous recombination and DNA double-strand break (DSB)...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001, Vol.61 (1), p.270-277
Hauptverfasser:	HUICHEN WANG, ZENG, Zhao-Chong, BUI, Tu-Anh, DIBIASE, Steven J, WEI QIN, FEN XIA, POWELL, Simon N, ILIAKIS, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Biological and medical sciences BRCA1 Protein - deficiency BRCA2 gene BRCA2 Protein Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA Damage DNA Repair - drug effects DNA Repair - genetics DNA Repair - physiology DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA, Neoplasm - radiation effects DNA-Activated Protein Kinase DNA-Binding Proteins Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Genes, BRCA1 - genetics Humans Kinetics Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutation Neoplasm Proteins - deficiency Neoplasm Proteins - genetics Nuclear Proteins Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Transcription Factors - deficiency Transcription Factors - genetics Tumor Cells, Cultured
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