Highly sensitive analysis of methamphetamine and amphetamine in human whole blood using headspace solid-phase microextraction and gas chromatography–mass spectrometry
A simple and highly sensitive method for analysis of derivatized methamphetamine (MA) and amphetamine (AM) in whole blood was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry electron impact ionization selected ion monitoring (GC–MS-EI-SIM). A...
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| Veröffentlicht in: | Forensic science international 2001-02, Vol.116 (1), p.15-22 |
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| creator | Okajima, Kazuo Namera, Akira Yashiki, Mikio Tsukue, Ichiro Kojima, Tohru |
| description | A simple and highly sensitive method for analysis of derivatized methamphetamine (MA) and amphetamine (AM) in whole blood was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry electron impact ionization selected ion monitoring (GC–MS-EI-SIM). A whole blood sample, deuterated-MA (d
5-MA), as an internal standard (IS), tri-
n-propylamine and pentafluorobenzyl bromide were placed in a vial. The vial was heated and stirred at 90°C for 30
min. Then the extraction fiber of the SPME was exposed at 90°C for 30
min in the headspace of the vial while being stirred. The derivatives adsorbed on the fiber were desorbed by exposing the fiber in the injection port of a GC–MS. The calibration curves showed linearity in the range of 0.5–1000
ng/g for both MA and AM. The time for analysis was about 80
min per sample. In addition, this proposed method was applied to two autopsy cases where MA ingestion was suspected. In one case, MA and AM concentrations in the mixed left and right heart blood were 165 and 36.9
ng/g, respectively. In the other case, MA and AM concentrations were 1.79 and 0.119
μg/g in the left heart blood, and 1.27 and 0.074
μg/g in the right heart blood, respectively. |
| doi_str_mv | 10.1016/S0379-0738(00)00341-8 |
| format | Article |
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5-MA), as an internal standard (IS), tri-
n-propylamine and pentafluorobenzyl bromide were placed in a vial. The vial was heated and stirred at 90°C for 30
min. Then the extraction fiber of the SPME was exposed at 90°C for 30
min in the headspace of the vial while being stirred. The derivatives adsorbed on the fiber were desorbed by exposing the fiber in the injection port of a GC–MS. The calibration curves showed linearity in the range of 0.5–1000
ng/g for both MA and AM. The time for analysis was about 80
min per sample. In addition, this proposed method was applied to two autopsy cases where MA ingestion was suspected. In one case, MA and AM concentrations in the mixed left and right heart blood were 165 and 36.9
ng/g, respectively. In the other case, MA and AM concentrations were 1.79 and 0.119
μg/g in the left heart blood, and 1.27 and 0.074
μg/g in the right heart blood, respectively.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/S0379-0738(00)00341-8</identifier><identifier>PMID: 11118748</identifier><identifier>CODEN: FSINDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adsorption ; Alkalies - metabolism ; Amphetamine ; Amphetamine - blood ; Amphetamine - isolation & purification ; Amphetamine - metabolism ; Amphetamines ; Autopsies ; Autopsy ; Biological and medical sciences ; Blood ; Calibration ; Central Nervous System Stimulants - blood ; Central Nervous System Stimulants - isolation & purification ; Central Nervous System Stimulants - metabolism ; Deuteration ; Electron impact ; Equilibrium ; Forensic medicine ; Forensic Medicine - methods ; Gas chromatography ; Gas Chromatography-Mass Spectrometry - methods ; Headspace ; Heart ; Heart Ventricles ; Highly sensitive ; Hot Temperature ; HS-SPME ; Humans ; Ingestion ; Ionization ; Mass spectrometry ; Mass spectroscopy ; Medical sciences ; Methamphetamine ; Methamphetamine - blood ; Methamphetamine - isolation & purification ; Methamphetamine - metabolism ; Pentafluorobenzyl bromide ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reproducibility ; Reproducibility of Results ; Sensitivity and Specificity ; Solid phase methods ; Solid phases ; Temperature ; Time Factors ; Whole blood</subject><ispartof>Forensic science international, 2001-02, Vol.116 (1), p.15-22</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><rights>2001. Elsevier Science Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-7999a7b6571e4bc9d24b82818d6e26cd9adcc82925dddf90bff6ef115a183f553</citedby><cites>FETCH-LOGICAL-c448t-7999a7b6571e4bc9d24b82818d6e26cd9adcc82925dddf90bff6ef115a183f553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0379073800003418$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=866130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11118748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okajima, Kazuo</creatorcontrib><creatorcontrib>Namera, Akira</creatorcontrib><creatorcontrib>Yashiki, Mikio</creatorcontrib><creatorcontrib>Tsukue, Ichiro</creatorcontrib><creatorcontrib>Kojima, Tohru</creatorcontrib><title>Highly sensitive analysis of methamphetamine and amphetamine in human whole blood using headspace solid-phase microextraction and gas chromatography–mass spectrometry</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>A simple and highly sensitive method for analysis of derivatized methamphetamine (MA) and amphetamine (AM) in whole blood was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry electron impact ionization selected ion monitoring (GC–MS-EI-SIM). A whole blood sample, deuterated-MA (d
5-MA), as an internal standard (IS), tri-
n-propylamine and pentafluorobenzyl bromide were placed in a vial. The vial was heated and stirred at 90°C for 30
min. Then the extraction fiber of the SPME was exposed at 90°C for 30
min in the headspace of the vial while being stirred. The derivatives adsorbed on the fiber were desorbed by exposing the fiber in the injection port of a GC–MS. The calibration curves showed linearity in the range of 0.5–1000
ng/g for both MA and AM. The time for analysis was about 80
min per sample. In addition, this proposed method was applied to two autopsy cases where MA ingestion was suspected. In one case, MA and AM concentrations in the mixed left and right heart blood were 165 and 36.9
ng/g, respectively. In the other case, MA and AM concentrations were 1.79 and 0.119
μg/g in the left heart blood, and 1.27 and 0.074
μg/g in the right heart blood, respectively.</description><subject>Adsorption</subject><subject>Alkalies - metabolism</subject><subject>Amphetamine</subject><subject>Amphetamine - blood</subject><subject>Amphetamine - isolation & purification</subject><subject>Amphetamine - metabolism</subject><subject>Amphetamines</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Calibration</subject><subject>Central Nervous System Stimulants - blood</subject><subject>Central Nervous System Stimulants - isolation & purification</subject><subject>Central Nervous System Stimulants - metabolism</subject><subject>Deuteration</subject><subject>Electron impact</subject><subject>Equilibrium</subject><subject>Forensic medicine</subject><subject>Forensic Medicine - methods</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>Headspace</subject><subject>Heart</subject><subject>Heart Ventricles</subject><subject>Highly sensitive</subject><subject>Hot Temperature</subject><subject>HS-SPME</subject><subject>Humans</subject><subject>Ingestion</subject><subject>Ionization</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical sciences</subject><subject>Methamphetamine</subject><subject>Methamphetamine - blood</subject><subject>Methamphetamine - isolation & purification</subject><subject>Methamphetamine - metabolism</subject><subject>Pentafluorobenzyl bromide</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Solid phase methods</subject><subject>Solid phases</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Whole blood</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc9u1DAQhyMEokvhEUCWkBAcArbzzzlVqAKKVIkDcLYm9mTjKomDxynsjXfgJXgunoRkd1UqLvXFsubzb-z5kuSp4K8FF-Wbzzyr6pRXmXrJ-SvOs1yk6l6yEaqSaSlVdj_Z3CAnySOiK855UcjyYXIilqWqXG2S3xdu2_U7RjiSi-4aGYzQ78gR8y0bMHYwTB1GGNy41iy7fXYj6-YBRva98z2ypvfespncuGUdgqUJDDLyvbPp1AEhG5wJHn_EACY6P-4Dt0DMdMEPEP02wNTt_vz8NQARowlNXAoYw-5x8qCFnvDJcT9Nvr5_9-X8Ir389OHj-dvL1OS5imlV1zVUTVlUAvPG1FbmjZJKKFuiLI2twRqjZC0La21b86ZtS2yFKECorC2K7DR5ccidgv82I0U9ODLY9zCin0lXfIkuJL8TFJVSXBZqAZ__B175OSxTJi3rxUmdKbn2LQ7UMiCigK2eghsg7LTgejWu98b1qlNzrvfG9Zr-7Jg-NwPaf7eOim-1BzLQtwFG4-iGU2UpsvU3ZwcKl9leOwyajMPRoHVhkaCtd3c85C_zBMz0</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Okajima, Kazuo</creator><creator>Namera, Akira</creator><creator>Yashiki, Mikio</creator><creator>Tsukue, Ichiro</creator><creator>Kojima, Tohru</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Highly sensitive analysis of methamphetamine and amphetamine in human whole blood using headspace solid-phase microextraction and gas chromatography–mass spectrometry</title><author>Okajima, Kazuo ; Namera, Akira ; Yashiki, Mikio ; Tsukue, Ichiro ; Kojima, Tohru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-7999a7b6571e4bc9d24b82818d6e26cd9adcc82925dddf90bff6ef115a183f553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adsorption</topic><topic>Alkalies - metabolism</topic><topic>Amphetamine</topic><topic>Amphetamine - blood</topic><topic>Amphetamine - isolation & purification</topic><topic>Amphetamine - metabolism</topic><topic>Amphetamines</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Calibration</topic><topic>Central Nervous System Stimulants - blood</topic><topic>Central Nervous System Stimulants - isolation & purification</topic><topic>Central Nervous System Stimulants - metabolism</topic><topic>Deuteration</topic><topic>Electron impact</topic><topic>Equilibrium</topic><topic>Forensic medicine</topic><topic>Forensic Medicine - methods</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>Headspace</topic><topic>Heart</topic><topic>Heart Ventricles</topic><topic>Highly sensitive</topic><topic>Hot Temperature</topic><topic>HS-SPME</topic><topic>Humans</topic><topic>Ingestion</topic><topic>Ionization</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medical sciences</topic><topic>Methamphetamine</topic><topic>Methamphetamine - blood</topic><topic>Methamphetamine - isolation & purification</topic><topic>Methamphetamine - metabolism</topic><topic>Pentafluorobenzyl bromide</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Reproducibility</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Solid phase methods</topic><topic>Solid phases</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Whole blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okajima, Kazuo</creatorcontrib><creatorcontrib>Namera, Akira</creatorcontrib><creatorcontrib>Yashiki, Mikio</creatorcontrib><creatorcontrib>Tsukue, Ichiro</creatorcontrib><creatorcontrib>Kojima, Tohru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okajima, Kazuo</au><au>Namera, Akira</au><au>Yashiki, Mikio</au><au>Tsukue, Ichiro</au><au>Kojima, Tohru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly sensitive analysis of methamphetamine and amphetamine in human whole blood using headspace solid-phase microextraction and gas chromatography–mass spectrometry</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>116</volume><issue>1</issue><spage>15</spage><epage>22</epage><pages>15-22</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><coden>FSINDR</coden><abstract>A simple and highly sensitive method for analysis of derivatized methamphetamine (MA) and amphetamine (AM) in whole blood was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry electron impact ionization selected ion monitoring (GC–MS-EI-SIM). A whole blood sample, deuterated-MA (d
5-MA), as an internal standard (IS), tri-
n-propylamine and pentafluorobenzyl bromide were placed in a vial. The vial was heated and stirred at 90°C for 30
min. Then the extraction fiber of the SPME was exposed at 90°C for 30
min in the headspace of the vial while being stirred. The derivatives adsorbed on the fiber were desorbed by exposing the fiber in the injection port of a GC–MS. The calibration curves showed linearity in the range of 0.5–1000
ng/g for both MA and AM. The time for analysis was about 80
min per sample. In addition, this proposed method was applied to two autopsy cases where MA ingestion was suspected. In one case, MA and AM concentrations in the mixed left and right heart blood were 165 and 36.9
ng/g, respectively. In the other case, MA and AM concentrations were 1.79 and 0.119
μg/g in the left heart blood, and 1.27 and 0.074
μg/g in the right heart blood, respectively.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>11118748</pmid><doi>10.1016/S0379-0738(00)00341-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0379-0738 |
| ispartof | Forensic science international, 2001-02, Vol.116 (1), p.15-22 |
| issn | 0379-0738 1872-6283 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adsorption Alkalies - metabolism Amphetamine Amphetamine - blood Amphetamine - isolation & purification Amphetamine - metabolism Amphetamines Autopsies Autopsy Biological and medical sciences Blood Calibration Central Nervous System Stimulants - blood Central Nervous System Stimulants - isolation & purification Central Nervous System Stimulants - metabolism Deuteration Electron impact Equilibrium Forensic medicine Forensic Medicine - methods Gas chromatography Gas Chromatography-Mass Spectrometry - methods Headspace Heart Heart Ventricles Highly sensitive Hot Temperature HS-SPME Humans Ingestion Ionization Mass spectrometry Mass spectroscopy Medical sciences Methamphetamine Methamphetamine - blood Methamphetamine - isolation & purification Methamphetamine - metabolism Pentafluorobenzyl bromide Public health. Hygiene Public health. Hygiene-occupational medicine Reproducibility Reproducibility of Results Sensitivity and Specificity Solid phase methods Solid phases Temperature Time Factors Whole blood |
| title | Highly sensitive analysis of methamphetamine and amphetamine in human whole blood using headspace solid-phase microextraction and gas chromatography–mass spectrometry |
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