Asymmetric CLASP-Dependent Nucleation of Noncentrosomal Microtubules at the trans-Golgi Network

Proper organization of microtubule arrays is essential for intracellular trafficking and cell motility. It is generally assumed that most if not all microtubules in vertebrate somatic cells are formed by the centrosome. Here we demonstrate that a large number of microtubules in untreated human cells...

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Veröffentlicht in:	Developmental cell 2007-06, Vol.12 (6), p.917-930
Hauptverfasser:	Efimov, Andrey, Kharitonov, Alexey, Efimova, Nadia, Loncarek, Jadranka, Miller, Paul M., Andreyeva, Natalia, Gleeson, Paul, Galjart, Niels, Maia, Ana R.R., McLeod, Ian X., Yates, John R., Maiato, Helder, Khodjakov, Alexey, Akhmanova, Anna, Kaverina, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell structures and functions CELLBIO Cells, Cultured Centrosome - metabolism Cytoskeleton, cytoplasm. Intracellular movements Fundamental and applied biological sciences. Psychology Golgi Apparatus - metabolism HeLa Cells Humans Membrane Proteins - metabolism Microtubule-Associated Proteins - metabolism Microtubule-Organizing Center Microtubules - metabolism Molecular and cellular biology Pigment Epithelium of Eye - metabolism Spindle Apparatus trans-Golgi Network - metabolism Tubulin - metabolism
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