Hepatocyte Growth Factor Is a Regulator of Monocyte-Macrophage Function

Hepatocyte growth factor (HGF) is a potent paracrine mediator of stromal/epithelial interactions, which is secreted as a matrix-associated inactive precursor (pro-HGF) and locally activated by tightly controlled urokinase cleavage. It induces proliferation and motility in epithelial and endothelial...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-01, Vol.166 (2), p.1241-1247
Hauptverfasser:	Galimi, Francesco, Cottone, Erika, Vigna, Elisa, Arena, Nicolo, Boccaccio, Carla, Giordano, Silvia, Naldini, Luigi, Comoglio, Paolo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion - immunology Cells, Cultured Chemotaxis, Leukocyte - immunology Culture Media - metabolism Granulocyte Colony-Stimulating Factor - biosynthesis Granulocyte Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - genetics Hepatocyte growth factor Hepatocyte Growth Factor - biosynthesis Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - physiology Humans Interleukin-6 - biosynthesis Interleukin-6 - genetics Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Monocytes - immunology Monocytes - metabolism Platelet Activating Factor - pharmacology Protein Precursors - metabolism Proto-Oncogene Proteins c-met - biosynthesis Proto-Oncogene Proteins c-met - blood Recombinant Proteins - pharmacology RNA, Messenger - biosynthesis Transcription, Genetic - immunology
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